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It has been more than a century tackling Anemia in CKD since its first description by Richard Bright in 1835.
👉 #NephMadness 2021 is featuring strong contenders from the #AnemiaRegion.
🤔 Let's find out why Anemia in CKD is an important consideration. #NSMCInternship
It has been more than a century tackling Anemia in CKD since its first description by Richard Bright in 1835.
👉 #NephMadness 2021 is featuring strong contenders from the #AnemiaRegion.
🤔 Let's find out why Anemia in CKD is an important consideration. #NSMCInternship
2/📊 What % of patients with CKD stage 4 have anemia based on KDOQI (Hb <13.5 g/dL for men and <12.0 g/dL for women) and WHO (<13.0 g/dL for men & <12.0 g/dL for women)?
3/
😳 Around 60% of the patients with stage 4 CKD not on dialysis have anemia based on KDOQI/WHO.
😟 Anemia contributes to significant morbidity in patients with CKD.
pubmed.ncbi.nlm.nih.gov/18359408/
😳 Around 60% of the patients with stage 4 CKD not on dialysis have anemia based on KDOQI/WHO.
😟 Anemia contributes to significant morbidity in patients with CKD.
pubmed.ncbi.nlm.nih.gov/18359408/
5/🗣 Manifestations of anemia in CKD:
❗Anemia in CKD leads to poor QoL and adverse outcomes including morbidity and mortality.
👉The adverse outcomes are associations and not been shown to be causal.
Modified from ajkd.org/article/S0272-…
❗Anemia in CKD leads to poor QoL and adverse outcomes including morbidity and mortality.
👉The adverse outcomes are associations and not been shown to be causal.
Modified from ajkd.org/article/S0272-…
6/What causes anemia in CKD?!
It is multifactorial -
✅EPO deficiency
✅Iron deficiency
✅Blood loss
✅Reduced RBC survival
✅Decreased bone marrow function
✅Uremia and inflammation
✅Malnutrition
jasn.asnjournals.org/content/23/10/…
It is multifactorial -
✅EPO deficiency
✅Iron deficiency
✅Blood loss
✅Reduced RBC survival
✅Decreased bone marrow function
✅Uremia and inflammation
✅Malnutrition
jasn.asnjournals.org/content/23/10/…
7/What is the💉 Role of iron and erythropoietin (EPO) in erythropoiesis!
📌EPO - produced from peritubular fibroblasts in renal cortex, O2 dependent mechanism.
📌Iron - absorbed from the intestine, controlled by store regulators and erythroid regulators.
📌EPO - produced from peritubular fibroblasts in renal cortex, O2 dependent mechanism.
📌Iron - absorbed from the intestine, controlled by store regulators and erythroid regulators.
8/
✔Kidney - primary organ responsible for erythropoiesis regulation.
✔Kidney failure → Decreased erythropoietin + Uremia => Hypoproliferative anemia.
sciencedirect.com/science/articl…
✔Kidney - primary organ responsible for erythropoiesis regulation.
✔Kidney failure → Decreased erythropoietin + Uremia => Hypoproliferative anemia.
sciencedirect.com/science/articl…
9/💬 Iron deficiency Anemia (IDA) in CKD may be
Absolute IDA - due to ↓ or absent iron stores caused by blood loss or from ↓ iron intake in the diet.
Functional IDA - due to inadequate incorporation of iron into erythroid precursors in spite of adequate iron stores.
Absolute IDA - due to ↓ or absent iron stores caused by blood loss or from ↓ iron intake in the diet.
Functional IDA - due to inadequate incorporation of iron into erythroid precursors in spite of adequate iron stores.
10/📕 Pathophysiology of Functional IDA
Hepcidin (key regulator of iron homeostasis) binds to Ferroportin (transmembrane conduit for the transfer of cellular iron to plasma) in the liver, macrophages and duodenum reducing intestinal iron release → Functional iron deficiency.
Hepcidin (key regulator of iron homeostasis) binds to Ferroportin (transmembrane conduit for the transfer of cellular iron to plasma) in the liver, macrophages and duodenum reducing intestinal iron release → Functional iron deficiency.
11/12
⌛ So, this was in short about Anemia in CKD. Stay tuned for the details on competitors from this region in the upcoming tweets.
-Oral Iron💊
-IV Iron💉
-HIF stabilizers🔥
⌛ So, this was in short about Anemia in CKD. Stay tuned for the details on competitors from this region in the upcoming tweets.
-Oral Iron💊
-IV Iron💉
-HIF stabilizers🔥
12/12
📌Meanwhile engage yourselves reading from #NephMadness #AnemiaRegion
Thank you: #NSMC @NSMCInternship @Nephro_Sparks @docanjuyadav @drM_sudha @captainchloride @JMTeakell @bourneauguste and the Team Two-bules!!
ajkdblog.org/2021/03/01/nep…
📌Meanwhile engage yourselves reading from #NephMadness #AnemiaRegion
Thank you: #NSMC @NSMCInternship @Nephro_Sparks @docanjuyadav @drM_sudha @captainchloride @JMTeakell @bourneauguste and the Team Two-bules!!
ajkdblog.org/2021/03/01/nep…
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