Thread by @AmlLabib

Glomerular crescents 🌙

❓What’s a crescent?

🔬Crescentic GN?

🧩 How are crescents formed?

🔬🗂 Types of crescents? ❗️Pseudo-crescents?
(1/6)
#renalpath #PathResidents #Pathbracket

❓A crescent is defined as two or more layers of cells that are partially or completely filling the Bowman’s space

📥composed of
-Mixture of cells(epithelial cells, monocytes and other leukocytes)
-fibrin
-fibrous matrix. (2/6)

🚨Non specific lesion, can be triggered by a variety of glomerular diseases
🔬Crescentic GN(CGN)?
▶️is a PATTERN of injury rather than a specific diagnosis
▶️Integration of clinical data, specific laboratory & immunologic tests can clarify the diagnosis underlying the CGN (3a/6)

Accurate categorization of CGN is critical for prognosis. (3b/6)

🧩 Crescents formation:
Different upstream mechanism ⬆️ ▶️ complement activation ▶️ vascular injury▶️ gaps through GBM▶️ coagulation within Boman’s space ▶️ fibrin formation with limited fibrinolysis▶️stimulation of parietal epithelial cell proliferation▶️ crescent formation(4/6

🔬🗂 Types of crescents?

🔃The activated parietal epithelial cells form cellular crescents.

🛣Cellular crescents either: - resolve
-or evolve into fibrocellular and fibrotic crescents. (5/6)

References: (6/6)
1.Consensus definitions for glomerular lesions by light and electron microscopy.... PMID: 32866505
2.Heptinstall’s Pathology of the Kidney(7th Ed).
3. Robbins Basic Pathology
4.ncbi.nlm.nih.gov/pmc/articles/P…