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Mar 24, 2021 12 tweets 9 min read Read on X
S-1 thread

@Zymergen( $ZY) surprised today w $100M Initial Public Offering. JPM, GS, BOA, Cowen

Last valued $1.75B

Word counts

"biofactur-": 173
Hyaline:140
"Nature" (capital N):39
#SyntheticBiology/#SynBio:26
#MachineLearning:24
@Amyris ( $AMRS):2
@Ginkgo:0
@Intrexon (RIP):0 Image
S-1 bit.ly/31b1qhl

$13M in R&D/collab revenue in 2020

$ZY spent "5 years & $50 million" to "launch" (w/o product rev) lead product Hyaline (electronic screen film)

Early version made w chem synthesis, NOT fermentation (#synbio), but plans to ferment later (lower COGS) ImageImageImageImage
^Hyaline chem synth underscores challenge of $ZY's biz model

$ZY trying to simultaneously design/build/test organisms AND market end products

Chem synth gets products into customer hands earlier than $XON/ $AMRS, but might improve top-line focusing on design/build/test w JV's Image
^ Benefit of a #synbio company creating a joint venture (JV) w a Fortune500 company is that it doesn't have to focus on selling end products. Then the #synbio co can focus its human & financial capital on its core competency (engineering microbes), and still share in risk/reward
^ By specializing in being a "go-to" #synbio intellectual property "fab" with JV model, it can also rack up more revenue-generating deals and satisfy investors

Fortune500 co's also recognize how disruptive #synbio already is in disrupting supply chains, and will pay to get ahead
There is also a Perceptive Advisors debt covenant subplot that was not apparent until $ZY filing

Had previously just assumed Perceptive only held $ZY equity

The Sept 2020 press release made mention of "growth financing" from Perceptive

prnewswire.com/news-releases/… Image
^ Sept 2020 Perceptive / $ZY "growth financing" was actually $100M credit facility

By YE20, $ZY was unable to comply w debt covenant, but got waiver

If $ZY defaults, Perceptive gets "SUBSTANTIALLY ALL assets, including IP"

So $ZY has an immediate interest in doing a $100M IPO Image
^ The $ZY S-1 document makes it clear that at least a portion of the $100M offering proceeds will go towards the Perceptive credit facility

$AMRS $XON
#SynBio Image
$ZY priced at around $3B cap

97,450,901 shares * $31

$31 was the high end

#SynBio
$AMRS $CDXS $NVZMY $ABCL
$TWST $BLI

Image

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More from @Varro_Analytics

Oct 25, 2021
🧵

Great clip from Voigt lab explaining technical barriers to creating *reliable* cell programs ("regulatory networks") with HUNDREDS of genes (like🦠found in nature)

$DNA has chipped away at some of these, though it can still only design reliable programs with ~5-10 genes

🧬
^Barriers $DNA has chipped away at:

Design:
•Codebase has many well-characterized parts
•Software to string 1000's of design variations together

Build:
@Gen9Bio tech for synthesizing big pieces of 🧬 ("challenging")

Test:
•Methods for debugging cell programs (reporters)
Circa 2016, Voigt lab at MIT said the limit for cell programs ("regulatory networks") in academia was ~2-4 genes

Compare this with naturally-occurring cell programs that might have hundreds of genes
Read 6 tweets
Oct 24, 2021
“Given all of the sensitivity about this work, it’s difficult to understand why NIH and EcoHealth have still not explained a number of irregularities with the reporting on this grant.”
- @DavidRelman, Stanford Med School

vanityfair.com/news/2021/10/n…
From Vanity Fair, of all publications:

“One distinctive segment of SARS-CoV-2’s genetic code is a furin cleavage site… That is just the feature that EcoHealth Alliance and the Wuhan Institute of Virology had proposed to engineer in the 2018 grant proposal.”
“If I applied for funding to paint Central Park purple and was denied, but then a year later we woke up to find Central Park painted purple, I’d be a prime suspect”
-Jamie Metzl, World Health Organization advisory committee on human genome editing
Read 4 tweets
Oct 11, 2021
$DNA

Discovered @alchemytoday over the weekend

He's a JHU PhD who is now a P.I. at ULisbon. Focuses on #singlecell microbiology🦠

He picked up on some *NOTABLE* details in 175 page short report released by 🦂 last week

Will curate his posts in this🧵

itqb.unl.pt/research/biolo…
On the possible psychology behind the design of the document (see formatting)

$DNA

More on the possible psychology behind the design of the document (see formatting)

$DNA

Read 20 tweets
Apr 11, 2021
DISCUSSION THREAD

Topic: $SRNGU/ $SRNG and potential Ginkgo Bioworks SPAC deal. Specifically, $20B valuation mentioned by Bloomberg

Will walk through some mkt data on chart below

Comments encouraged

#SynBio
$ZY
$AMRS $CDXS $ABCL $SYBX $PGEN
$BLI $TWST $TXG
$WUXAY $CRL $PPD
^Will preface this w list of most interesting things in $SRNGU/ $SRNG S-1

1). HUGE cash trust: $1.5B

2). Mostly entertainment experts (they SPAC'd DraftKings), but sector agnostic

3). Criteria: "High growth +FCF potential"

2). One bio link: $ALLO $KRON @Vida_Ventures @bt_prop
Let's also establish

i). Ginkgo is IP creation biz (a #synbio $TXN/ $INTC/ $AMD) housed in automated CRO (see $PPD $WUXAY $CRL) "on steroids." That gets paid in cash+ stock/royalties

ii). Biology inherently hard to scale, but part of revenue magic of Ginkgo is code reuseability
Read 23 tweets

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