$ZY spent "5 years & $50 million" to "launch" (w/o product rev) lead product Hyaline (electronic screen film)
Early version made w chem synthesis, NOT fermentation (#synbio), but plans to ferment later (lower COGS)
^Hyaline chem synth underscores challenge of $ZY's biz model
$ZY trying to simultaneously design/build/test organisms AND market end products
Chem synth gets products into customer hands earlier than $XON/ $AMRS, but might improve top-line focusing on design/build/test w JV's
^ Benefit of a #synbio company creating a joint venture (JV) w a Fortune500 company is that it doesn't have to focus on selling end products. Then the #synbio co can focus its human & financial capital on its core competency (engineering microbes), and still share in risk/reward
^ By specializing in being a "go-to" #synbio intellectual property "fab" with JV model, it can also rack up more revenue-generating deals and satisfy investors
Fortune500 co's also recognize how disruptive #synbio already is in disrupting supply chains, and will pay to get ahead
There is also a Perceptive Advisors debt covenant subplot that was not apparent until $ZY filing
Had previously just assumed Perceptive only held $ZY equity
The Sept 2020 press release made mention of "growth financing" from Perceptive
Great clip from Voigt lab explaining technical barriers to creating *reliable* cell programs ("regulatory networks") with HUNDREDS of genes (like🦠found in nature)
$DNA has chipped away at some of these, though it can still only design reliable programs with ~5-10 genes
🧬
^Barriers $DNA has chipped away at:
Design:
•Codebase has many well-characterized parts
•Software to string 1000's of design variations together
Build:
•@Gen9Bio tech for synthesizing big pieces of 🧬 ("challenging")
Test:
•Methods for debugging cell programs (reporters)
Circa 2016, Voigt lab at MIT said the limit for cell programs ("regulatory networks") in academia was ~2-4 genes
Compare this with naturally-occurring cell programs that might have hundreds of genes
“Given all of the sensitivity about this work, it’s difficult to understand why NIH and EcoHealth have still not explained a number of irregularities with the reporting on this grant.”
- @DavidRelman, Stanford Med School
“One distinctive segment of SARS-CoV-2’s genetic code is a furin cleavage site… That is just the feature that EcoHealth Alliance and the Wuhan Institute of Virology had proposed to engineer in the 2018 grant proposal.”
“If I applied for funding to paint Central Park purple and was denied, but then a year later we woke up to find Central Park painted purple, I’d be a prime suspect”
-Jamie Metzl, World Health Organization advisory committee on human genome editing
i). Ginkgo is IP creation biz (a #synbio $TXN/ $INTC/ $AMD) housed in automated CRO (see $PPD $WUXAY $CRL) "on steroids." That gets paid in cash+ stock/royalties
ii). Biology inherently hard to scale, but part of revenue magic of Ginkgo is code reuseability