On the eve of the EU video summit tomorrow, plenty of briefing on vaccines, so here is a guide to some of the sentiment out there:
1/ The European Commission's new vaccine export restrictions will be discussed by leaders but the reality is that under EU trade rules the Commission has a prerogative to amend regulations in this way...
2/ There is a growing number of leaders who will voice their concern at a restrictions leading to a lose-lose tit-for-tat vaccine trade war, and reputational damage for the EU. Ireland, NL, Sweden, Belgium and others in this camp
3/ France, Italy and others believe the EU must get tougher and start looking after its own citizens by pressurising other countries - and in particular AstraZeneca - to play ball
4/ If a large number of leaders voice overt opposition - and if Germany joins that side of the argument - then it may prompt a rethink by the Commission. However, a parallel track of diplomacy may mean that that won't be necessary...
5/ There is a view is that escalating disputes over which vaccine contract is paramount, and threatening export restrictions, will not - ultimately - get more Europeans vaccinated
6/ "We are against anything that makes life more difficult instead of getting everyone vaccinated as soon as possible," says one EU diplomat.
7/ "The way to do this is diplomacy and to try and have negotiations with our friends across the Atlantic, Mexico, Canada, the UK, India to come to an agreement. This is what president @vonderleyen is doing."
8/ At the same time, the three way talks between AstraZeneca, former UK ambassador to the EU @TimBarrowFCO and the Commission could be bearing fruit
9/ The UK and Commission have just issued their first ever non-NI Protocol statement since Brexit happend on Jan 1.
10/ "We have been discussing what more we can do to ensure a reciprocally beneficial relationship between the UK and EU on COVID-19.
11/ "Given our interdependencies, we are working on specific steps we can take - in the short-, medium - and long term - to create a win-win situation and expand vaccine supply for all our citizens.
12/ "In the end, openness and global cooperation of all countries will be key to finally overcome this pandemic and ensure better preparation for meeting future challenges.

"We will continue our discussions”

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More from @tconnellyRTE

24 Mar
Main points of the European Commission's new vaccine export restrictions:
1/ On top of the Jan 29 transparency mechanism, ie whereby member states must grant an authorisation to vaccine exports outside the EU to ensure they're compliant with EU vaccine contracts, there are added criteria
2/ Proportionality: roughly speaking, how much of the recipient country has already been vaccinated and what is the epidemiological situation in that country
Read 12 tweets
23 Mar
Worth noting by Sandra Gallina, EU's chief vaccine negotiator: last year the Commission entered advanced purchase agreements with pharma companies, ie buying doses of vaccines which did not yet exist.
2/ In order to conclude the contract the pharma companies needed a commitment of a certain amount of doses, ie an incentive to research + produce, so they would need a commitment to produce 300m doses for example
3/ However, as the negotiator, the European Commission needed to be sure the doses were being bought by member states. At the beginning, member states had to decide whether to stay in or out of the programme.
Read 7 tweets
22 Mar
Ireland's Minister for Foreign Affairs @simoncoveney says if the UK delivers a clear road map setting out how it will implement the NI Protocol, then the atmosphere would change and the EU would be in a position to “look at” flexibilities and extensions to grace periods.
2/ Coveney was speaking in Brussels after meeting the European Commission vice president @MarosSefcovic, co-chair of the EU-UK Joint Committee.

Mr Coveney said there had been contacts between EU and UK officials with a view to resuming more formal talks around the Protocol
3/ “I think certainly the EU side wants to get a process underway again so that both sides are talking to each other,” he told @rtenews
Read 11 tweets
16 Mar
Peter Arlett EMA: "If we look at what we would expect in the European population for thromboembolic events the number of reported events is far lower than we would expect in the background population
"The review is focusing on a small number of case reports of very rare + rather unusual thrombotic events, including thrombosis combined with thrombocytopenia. When you get down to individual cases,1, 2, 3 or 4 cases - then the epidemiological approach becomes much more difficult
"firstly it becomes difficult to get the background rates, there is less published in the literature, there is less available in electronic health care databases, therefore the focus is much more on looking at the clinical features of the individual reported case..."
Read 6 tweets
16 Mar
Peter Arlett, head of EMA pharmacovigilance and epidemiology: With these vaccines we had very large clinical trials which gave very good evidence they were safe.
"Once the product gets on market you use the vaccine in far, far greater numbers and we therefore put in place lots of measures to ensure we're colleting date very quickly"
"In addition we are putting in place real world data studies which are extremely useful, they tell us the background rates of certain rare events, including thromboembolic events [blood clots etc]"
Read 4 tweets
16 Mar
NEW: European Medicines Agency (EMA) says it continues to evaluate data on blood clot concerns related to AstraZeneca, and any additional possible side effects, and has pulled in experts on blood clots. "It's an ongoing process," according to director Emer Cooke
[Blood clot] events have occurred in a very small number of people - Cooke. EMA has called on expert committee to establish if there has been a causal relationship between blod clots + AZ vaccine
EMA is evaluating each reported incident on a case by case basis
Read 5 tweets

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