Thread by @fitterhappierAJ

1/ I see you raised it in March @MLevitt_NP2013 but as the saying goes, what goes up must come down

The work dashes X reactive T cells- they poorly proliferate in the few people that possess them.

X reactive abs, as your image queries, are equally rare

https://twitter.com/MLevitt_NP2013/status/1379003334422499328

2/ Why the focus on T cells? We have yet to see any protective effect of T cell memory without antibodies from infection.

Rather, it is sera which is seen to exert a protective effect after recovery, not T cells alone. medrxiv.org/content/10.110… In regard to the paper...

3/ We must also understand that T cells do not exert immunity prior to any sort of infection, unless they 'see' antigen from an exposure/vaccine.

The fact the T cells have responded, means indeed there was a viral challenge, and the cells 'saw' antigen. So let's look...

4/ After an infection I would hope more of these people would have virus-specific CD4 and CD8 memory detectable within three months!

And when we give a super generous 10 day stimulation to the cells...

5/ ... 6 and 17 percent of people who were infected in the last 3 months did not have expandable CD4/8 T cell memory! 🤯

How are we meant to have this be endemic? How many times can one sequentially roll an 80 percent bet before going bust?

6/ Finally, the notion that these T cells will prevent infection is unproven! Sera is the robust correlate

These are peoples lives, not experiments to be done in the pursuit of a married hypothesis.

Your wife must be jealous :^)

You would be the 1st man to marry T cells.