Thread by @musicrocksit452

BLOOD CLOTS & COVID VACCINES

J&J & Astra Zen Viral vector vaccines use a modified version of a different virus to deliver instructions to our cells. AZ also uses a mod virus from chimps. Moderna & Pfizer vaccines don't use the same technology.

How they work, differences
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1)Some experts suspect the key technology used to make the Johnson & Johnson vaccine as well as the AstraZeneca vaccine may play a role in the blood clots.

2)Both the AstraZeneca & the Johnson & Johnson vaccines use an inactivated form of a common cold virus, called an adenovirus, to teach the immune system to recognize the spike protein found of the surface of the coronavirus

3)In both, the adenovirus is genetically modified so it does not cause cold symptoms. In the AstraZeneca vaccine, the modified virus comes from chimpanzees, in Johnson & Johnson's, the virus comes from humans.

4)Experts believe it's possible that on rare occasions, the adenovirus itself could lead to clotting, due to a reaction involving platelets.

5)"We also know that adenoviruses themselves can cause platelet activation and binding," said Poland, who is also a consultant for multiple Covid-19 vaccine manufacturers, including Johnson & Johnson.

6)No such clotting issues have been reported with the Covid-19 vaccines made by Pfizer-BioNTech or Moderna, health officials said. Those vaccines use a different type of technology, called messenger RNA, or mRNA.

7)How Pfizer & Moderna shots work instead of DNA, they insert mRNA, a molecule already found in the body which stores directions that teach our cells to make copies of coronavirus spike protein, sparking the creation of antibodies w/out assistance of a separate harmless virus.

8)The CDC and FDA are recommending that people who have received the J&J vaccine within the last 3 weeks who develop severe headache, abdominal pain, leg pain or shortness of breath should contact their health care provider.

sciencemag.org/news/2021/04/c…
miamiherald.com/news/nation-wo…?
yalemedicine.org/news/covid-19-…
theconversation.com/johnson-and-jo…
nbcnews.com/health/health-…