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Apr 19, 2021 15 tweets 5 min read Read on X
Omg I am LOVING this story

TL:DR - it is not a study, published in a journal dedicated to unusual hypotheses, and not really "from a major university" 1/n
2/n The article in question is a review of face masks. At face value, it's essentially an opinion piece arguing that masks are ineffective ncbi.nlm.nih.gov/pmc/articles/P…
3/n Digging a little bit deeper, some of the stuff in here is pretty obviously wrong. For example, this incorrect statement about 99% mild/asymptomatic is referenced to Worldometers (not a specific graph, just the site)
4/n This excerpt in quotation marks is not a direct quotation, and is given totally out of context from the source article by Fauci et al
5/n So the piece is wrong about COVID-19. But it also appears to be wrong about masks quite a lot
6/n For example, here's a paragraph where it is simply assumed that facemasks cause chronic hypoxemia/hypercapnia. The four references are 3 physiology textbooks and another review piece
7/n The WHO document referenced here was updated December 2020 and now completely contradicts both this assertion and indeed the entire paper
8/n So, I think it's fair to say that this opinion piece probably doesn't represent either a scientific study or even really evidence per se, and it gets a lot wrong about both masks and COVID-19

How did it get published?
9/n Well, the journal itself gives us a hint

The description alone of Medical Hypotheses is pretty interesting stuff
10/n Reading some previous work published by the paper gives you an idea of what kind of "novel, radical" ideas which "would be rejected" elsewhere they sometimes put out
11/n (In the journal's defense, they do also put out lots of less fringe hypotheses, they appear to take seriously the idea of giving everyone's ideas a forum for discussion)
12/n As to the Stanford connection?

Well, the author appears to be a physical therapist at a hospital near Stanford that has an affiliation for teaching purposes with the university
13/n We can split hairs, but I'm not sure this qualifies as saying that the study is produced by Stanford
14/n Anyway, regardless of what you think about masks, the paper has numerous errors and is probably not a useful resource for determining whether to use them or not
15/n None of this has stopped anyone citing the "study" as evidence of anything, of course, because no one checks the facts of things they agree with!

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More from @GidMK

Mar 4
The final large published trial on ivermectin for COVID-19, PRINCIPLE, is now out. Main findings:

1. Clinically unimportant (~1-2day reduction) in time to resolution of symptoms.
2. No benefit for hospitalization/death. Image
Now, you may be asking "why does anyone care at all any more about ivermectin for COVID?" to which I would respond "yes"

We already knew pretty much everything this study shows. That being said, always good to have more data!
The study is here:

For me, the main finding is pretty simple - ivermectin didn't impact the likelihood of people going to hospital or dying from COVID-19. This has now been shown in every high-quality study out there.pubmed.ncbi.nlm.nih.gov/38431155/
Read 8 tweets
Feb 20
Fascinating study.

What's particularly interesting is a finding that the authors don't really discuss in their conclusion. These results appear to show that gender affirming care is associated with a reduction in suicide risk 1/n
2/n The paper is a retrospective cohort study that compares young adults and some teens who were referred for gender related services in Finland with a cohort that was matched using age and sex. The median age in the study was 19, so the majority of the population are adults. Image
3/n The study is very limited. The authors had access to the Finnish registries which include a wide range of data, but chose to only correct their cohorts for age, sex, and number of psychiatric appointments prior to their inclusion in the cohort.
Read 11 tweets
Oct 26, 2023
These headlines have to be some of the most ridiculous I've seen in a while

The study tested 18 different PFAS in a tiny sample of 176 people. Of those, one had a barely significant association with thyroid cancer

This is genuinely just not news at all Image
Here's the study. I'm somewhat surprised it even got published if I'm honest. A tiny case-control study, they looked at 88 people with thyroid cancer and 88 controls thelancet.com/journals/ebiom…
Here are the main results. There was a single measured PFAS which had a 'significant' association with the cancer, the others just look a bit like noise to me Image
Read 7 tweets
Oct 11, 2023
A new study has gone viral for purportedly showing that running therapy had similar efficacy to medication for depression

Which is weird, because a) it's not a very good study and b) seems not to show that at all 1/n
Image
Image
2/n The study is here. The authors describe it as a "partially randomized patient preference design", which is a wildly misleading term. In practice, this is simply a cohort study, where ~90% of the patients self-selected into their preferred treatment sciencedirect.com/science/articl…
3/n This is a big problem, because it means that there are likely confounding factors between the two groups (i.e. who is likely to choose running therapy over meds?). Instead of a useful, randomized trial, this is a very small (n=141) non-randomized paper
Read 15 tweets
Oct 6, 2023
This is SO MISLEADING

The study showed that COVID-19 had, if anything, very few long-term issues for children! As a new father, I find this data very reassuring regarding #LongCovid in kids 1/n Image
2/n The study is here, it's a retrospective cohort comparing children aged 0-14 who had COVID-19 to a matched control using a database of primary care visits in Italy
onlinelibrary.wiley.com/doi/10.1111/ap…
3/ The authors found that there was an increased risk of a range of diagnoses for the kids with COVID-19 after their acute disease, including things like runny noses, anxiety/depression, diarrhoea, etc Image
Read 13 tweets
Sep 20, 2023
This study has recently gone viral, with people saying that it shows that nearly 20% of highly vaccinated people get Long COVID

I don't think it's reasonable to draw these conclusions based on this research. Let's talk about bias 1/n Image
2/n The study is here. It is a survey of people who tested positive to COVID-19 in Western Australia from July-Aug 2022 medrxiv.org/content/10.110…
3/n This immediately gives us our first source of bias

We KNOW that most cases of COVID-19 were missed at this point in the pandemic, so we're only getting the sample of those people who were sick enough to go and get tested
Read 12 tweets

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