#Immunity from SARS-CoV-2 mRNA vaccination verses infection are distinctly different. C19 patients had augmented interferon responses & effector T/ B cells, while vaccine recipients had high circulating memory T & B cells without interferon response [tinyurl.com/yc3wxbtz].
(2) Viruses modulate host genomes to enhance their own survival and replication. This has been going on for billions of years where both DNA and RNA viruses can capitalize on epitranscriptomic modifications to maximize viral gene expression [tinyurl.com/7s6uj4um].
(3) Viruses have shaped and built the genomes of organisms to survive for billions of years. [tinyurl.com/3kbcjcdv]. In human history, viruses like EBV is known to reprogram host metabolism/gene expression to proliferate and increase pathogenicity [tinyurl.com/4r799jm5]
(4) In reprogramming host genomes, the Hepatitis C leaves long-lasting effects that may cause liver cancer long after complete eradication of original infection [tinyurl.com/ra4kzht4]. SARS-CoV-2 is an RNA virus. It can also remodel the human genome [tinyurl.com/j5xvbkjp].
(5) Reduced cytotoxic effector T/NK cells in vaccinated individuals may be beneficial in lowering inflammatory responses that result in severity and mortality. On the other hand, does a less robust immune response upon infection mean possible greater genome remodeling by CoV-2?
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