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Gabor Erdosi 🧩📄📊🧭 Profile picture
@gerdosi
Apr 28, 2021 • 28 tweets • 8 min read • Read on X
There’s a curious correlation between countries/regions of high prior SARS2 exposure and a resurgence upon the start of mass V immunization programs. I’ve been thinking a lot about this lately, and the only explanation that could fit observations is… 1/
bmj.com/content/372/bm…
reactivation of dormant viruses in the population. (Seasonal) respiratory viral dormancy has been debated a lot for decades, but there’s still no consensus on where exactly these virions could lay dormant in the body, nor on the trigger(s) & mechanism(s) responsible for… 2/
reactivation. In light of recent research, my (educated?) guess is that the small intestine, and associated immune structures, is more likely place for this to occur than the respiratory tract. Admittedly, this is speculative, but neither implausible nor could I come up with… 3/
an explanation that better fits what’s seen in more and more countries.
Initially, I thought that poorly organized vaccination campaigns and careless behavior of vaccinated might explain the phenomenon, but it’s been becoming clear that this cannot be the case.
➟ #dormancy❓4/4
I’ll keep amending this mini-thread with (potentially) supporting evidence.
Just as infection with other viruses, vaccination can also reactivate e.g. shingles. gizmodo.com/what-to-know-a…
Immunosuppressive states are also known to result in reactivation of dormant viruses. Space travel is one such example. The week (or so) following a strongly immunogenic systemic vaccination is also immunosuppressive.
popsci.com/spaceflight-re…
Adding this case report here. Thanks for sharing.
Evidence for viral dormancy at least up to 6 months.
I forgot about one of the most obvious examples of (transient) immunosuppression: irradiation. Note the time span of 1-2 weeks.
academic.oup.com/jes/article/5/…
These findings may support the case.
Longitudinal following a lot of cats showed that feline coronavirus can establish chronic infection and perhaps dormancy with periodic deactivation as well. (No sequencing was done to confirm.)
bvajournals.onlinelibrary.wiley.com/doi/full/10.11…
Look at this, population data from Denmark.
“Suspected COVID-19 cases that occurred within 7 days after any vaccination were 409 in the vaccine group vs. 287 in the placebo group.”
Largest collection of real world examples I’ve seen so far.
The phenomenon described in Ebola as well.
Now, this is really intriguing. Image
The discrepancy in below data from Israel suggests the same. Cases and deaths increase during the ~2-week period following the first vaccination. I find it a bit weird that the authors decided not to report on this part at all.
Here you go. Both antigen (S1) and viral RNA is confirmed >12 months in monocytes derived from survivors of severe COVID and ‘long COVID’. Hopefully the authors will map other antigen presenting cells and various tissue localization in the future.
biorxiv.org/content/10.110…
Similarly intriguing development in Uruguay.
“Almost half of Kenyan adult donors had evidence of past SARS-CoV-2 infection by March 2021.
***Between March and June, 2% of the population were vaccinated against COVID-19 and the country experienced a third epidemic wave***.”
Emphasis mine
medrxiv.org/content/10.110…
Look how this has been going.
nejm.org/doi/full/10.10… Image
Long COVID is correlated with EBV reactivation. Some people describe ‘long vaccine’ as well. Intriguing
mdpi.com/2076-0817/10/6…
The increased odds can easily be observed in these data, but there's an uptick even after the second jab. This phenomenon is clearly related to vaccination.
Intestinal biopsy study/abstract
“More than half a million doses are being administered a day”
+ “We’re currently experiencing the highest number of new cases reported so far”
Where have we seen that combo before? 🤔
nature.com/articles/d4158…
Proper observation: “During the first few days after vaccination… the odds of vaccinated people testing positive was higher” 😮
Dubious explanation:
“suggesting that vaccination was being targeted at those at higher risk of infection.” 🤡
is.gd/UfSuAX Image
A pair of tweets, more food for thought along the above.
It seems that the effect is negatively correlated with age, so the highest risk of immunosuppression is in kids!

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More from @gerdosi

Gabor Erdosi 🧩📄📊🧭 Profile picture
Feb 18, 2023
Here I was called a COVID denier (what is that?), even though almost everything I stood for has been very close to reality since about March 2020. In fact, the only thing I was wrong about was the real world CFR of the virus. Back then I didn’t understand that poor management…
…was responsible for many deaths. Too early and unnecessary use of ventilators, too early and too high dose use of dexamethasone, remdesivir administration in hospitalized patients, avoidance of adding cheap and very low risk prophylactics, etc.
I only recognized these later.
I do remember when ventilator use was cut in half from one week to the other, following a protocol change in May 2020. Then I read this review from 2017 & realized that a lot more had been known about disease treatment than what was happening in hospitals. How could this happen?
Read 5 tweets
Gabor Erdosi 🧩📄📊🧭 Profile picture
Feb 15, 2022
Dude either has no clue about what ‘immunity’ is, or has a very narrow tunnel view of it. Alternatively he’s deliberately spreading misinformation here.
NB, more typical courses have been:
Infection with Wuhan + Omicron
Infection with Alpha + Omicron
Infection with Wuhan + Delta + Omicron
Etc.
Guess how these typical scenarios fair against vaccination + Omicron? Yep, you’re absolutely right.
Immunology noobs question my assessments above.
Please consider that the study only looked at systemic humoral immunity and Ab binding to the spike protein. Then think about all the layers of immunity omitted from the analysis, e.g. innate, mucosal, T cells, to all antigens, etc.
Read 4 tweets
Gabor Erdosi 🧩📄📊🧭 Profile picture
Dec 20, 2021
If you’re heading to the hospital with COVID make sure to declare that you’re allergic to remdesivir. It’s ineffective anyway.

Kidney disorders as serious adverse drug reactions of remdesivir in coronavirus disease 2019: a retrospective case–noncase study kidney-international.org/article/S0085-… Text Shot: Our findings, ba...
While remdesivir is still touted as ‘safe and effecrive’ in the COVID response of many countries, public health officials start removing health insurance reimbursement for vitamins and minerals due to lack of efficacy shown… Could you make this up? businessinsider.co.za/medical-scheme…
My sad personal experience echoes this. theepochtimes.com/controversial-…
Read 4 tweets
Gabor Erdosi 🧩📄📊🧭 Profile picture
Dec 10, 2021
‘Pandemic’ (changed by WHO in 2009)
‘Vaccine’ (changed by CDC in 2021, where kefir or vitamin D now fully qualify)
‘Peer reviewed’ (clueless people repeat it as mantra)
‘Breakthrough infection’ (if there’s robust immunity
‘T cells’ (ignored and ridiculed until Omicron appeared)
Oops, some editing issue at ‘peer reviewed’
If there’s robust immunity infecfion doesn’t occur. It only does if immunization was unsuccessful.
I think that we can safely add
‘hybrid immunity’
when it’s used as some superhuman state instead of natural immunity with repeated pathogen/antigen exposure.
Read 4 tweets
Gabor Erdosi 🧩📄📊🧭 Profile picture
Dec 6, 2021
A recently developed method, that expresses full spike trimers, enables more accurate measurement of binding IgG1 antibodies. Quite a few interesting results in this study.
First of all, the second dose of mRNA vaccines adds very little extra binding. medrxiv.org/content/10.110…
More importantly, the absolute increase in Delta variant binding antibodies following administration of the 2nd dose to previously infected people is limited to a small subset of adults. At the same time, the relative number of Delta binding Ab to non-binding (old Wuhan) Ab is…
…terribly low. What’s the use of that thick soup of sky high antibodies then? Triggering autoimmunity? 🤔
The authors are not impressed either, although expected such results from shotgun injecting the same antigen, leaving no time for maturation.
Read 4 tweets
Gabor Erdosi 🧩📄📊🧭 Profile picture
Oct 11, 2021
Let me strip the unnecessary narrative out of this otherwise nice study/abstract to get a clear picture. Short thread 🧵

Anti-SARS-CoV-2 receptor binding domain antibody evolution after mRNA vaccination
nature.com/articles/s4158…
How infection elicits broad protection
“SARS-CoV-2 infection produces B cell responses that continue to evolve for at least one year. During that time, memory B cells express increasingly broad and potent antibodies that are resistant to mutations found in variants of concern”
Following vaccination
“Between prime and boost, memory B cells produce antibodies that evolve increased neutralizing activity, but there is no further increase in potency or breadth thereafter.”
= the booster is too close to the priming dose and prevents affinity maturation.
Read 8 tweets

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