Deputy chief medical officer Van Tam says UK covid cases are as low as they are going to get. Here is a visual reminder of where Israel and UK are at currently with cases (ours are just over 2,000 a day).
The briefing can be seen here:
26.50 Van Tam says: solid data on the way vaccine can cut household transmission.
This data is after *one* dose and transmission should be reduced further with two doses.

Estimates are conservative says Van Tam.
46:01 Van Tam: there are some twists and turns ahead... planned easements will increase R, at same time hope continued vaccine rollout will put downward pressure on R. Competing forces in next few weeks.
Van Tam: we need to go further than [42 year olds] to put us in a "sustainably safe place".

All the data we have so far is largely generated after Christmas, against the Kent variant, we are extremely confident our current vaccines work against dominant variant in the UK
Van Tam: other variants in headlines India, SA and Brazil. Those case numbers have grown... couldn't call them trivial. But .. I don't see them "rushing away" now or in next few weeks in terms of giving us a new kind of problem.
Van Tam: when lab-based neutralisation studies show that antibodies do not neutralise the virus that doesn't tell us that vaccines don't work...because doesn't look at T-cell immunity.
Van Tam: we do see level of neutralisation fall between Kent and SA variants with current vaccines. But we can't say what the true clinical impact will be.
Likely in my view, the first thing to go will be protecting against infection ...
..but I hope protecting against severe disease... will be solid and much more lasting.
Van Tam: but potentially need to vaccinate again, and possibly with variant vaccines.
Hancock: we no longer look at cases as an inevitable precursor to future hospitalisations and deaths.

That was a reasonable rule of thumb throughout the autumn, that is no longer the case.

We are going to have to live with coronavirus much like we do flu....
Flu is something we do something about, but it isn't something that dominates our lives.... that is the strategic goal.
JVT: if you need to boost in the autumn, do you give folks third dose of same vaccine... or do you give them someting different?

A study Cov-boost starting soon, people invited to different vaccines as booster, will get an idea of which give you the highest boost...
.. and which give the broadest boost to different variants.
(This is apparently complicating the question of what vaccine to donate because UK wants the optionality still to give different third doses).
JVT: if vaccine program continues well, third wave may be just third upsurge and much less significant because delinking to cases and deaths.

Inconceivable there will be no further bumps in road between now and next year. Anticipate this in autumn and winter.
JVT: So much depends on vaccination and getting to youngest and what the variants bring us, which is a "biological unknown at this point"

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More from @natashaloder

25 Jan
January 23rd edition. We have so many vaccine and covid stories & visuals this week, I've assembled a reading list of them all.

How fast can vaccination against covid-19 make a difference? Israel has some answers. economist.com/science-and-te… Image
A successful vaccination drive will be a shot in the arm for Boris Johnson's government
economist.com/britain/2021/0… Image
Nationalism and geopolitics are slowing innoculations in Asia.
economist.com/asia/2021/01/2… Image
Read 11 tweets
31 Dec 20
For anyone following the dosing debate @peterbachmd @matthewherper this has just been published.

Unfortunately, I have to go and make supper for my family. I look forward to reading your thoughts.
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Read 7 tweets
7 Feb 20
Breaking: Singapore proposing social distancing measures in the wake of evidence of some community spread. Warns more stringent measures might be necessary. #2019n_CoV
Minister says: First, we will advise all event organisers to cancel or defer non-essential large-scale events. For those who wish to proceed, we will want them to take all necessary precautions....#2019n_CoV
Second, all employers and individuals should implement regular temperature-taking. They should be done at least twice daily. #2019n_CoV
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22 Oct 19
@JohnTuckerPhD @John_LaMattina Peer reviewed paper in Addiction. sciencedaily.com/releases/2019/…
@JohnTuckerPhD @John_LaMattina “Put simply, drug-related payments to physicians seem to increase drug prescriptions, and higher payments seem to increase them more."
@JohnTuckerPhD @John_LaMattina “From 2014 to 2016, the doctors who received payments prescribed, on average, over 13,070 daily doses of opioids per year more than their unpaid colleagues”
Read 4 tweets
10 Oct 19
Fantastic news. @DrMikeRyan from @WHO spoke this morning of significant progress in DRC, and expresses gratitude and hope that the world is getting on top of this virus.

Ebola is still transmitting but is now cornered in a smaller geographic area.
Lots of hard work getting to this point with Ebola. @DrMikeRyan says “I do think that vaccination has had a major impact on the dynamics of the epidemic”.
Another factor is the availability of treatment. Knowledge of the new treatments means that patients are much more likely to present themselves for care. If they do they are much more likely to survive too...
Read 8 tweets
15 Mar 19
THREAD: Sometime in the next few weeks I'm expecting Apple to switch on its ECG function on its watch in the UK.
Apple is not ready to discuss how this device will be approved. Nor whether it has provided any data on its watch to the health services such as @NHSEngland that will have to handle patients.
Watch approval will *probably* be a CE mark as a class 2a medical device, granted by private firms known as notified bodies. These assess if a product sold meets certain standards. You have no right to information from this process.
Read 17 tweets

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