Delighted to share our review on the #ferret as a model system for #neocortex development and evolution. It was great to write this with @Carlottagilard3. @humantechnopole @FrontCellDevBio frontiersin.org/articles/10.33… 1/
The main reasons that make ferret an important neurodevelopmental animal model are:
1)Similarly to primates, ferret has an expanded and folded neocortex with a diversity of proliferative neural stem and progenitor cells. 2/
1)Similarly to primates, ferret has an expanded and folded neocortex with a diversity of proliferative neural stem and progenitor cells. 2/
2)It’s brain development is protracted into postnatal period making it more accessible to manipulation.
3)Ferret shows important similarities to human immune response, making it a suitable model for various pathological conditions. 3/
3)Ferret shows important similarities to human immune response, making it a suitable model for various pathological conditions. 3/
In our review we outline the mean features of the ferret neocortex development with special emphasis on neural stem and progenitor cells, neuronal migration, cortical folding and development of cortical areas. 4/
We further list the main techniques used to manipulate the neocortex development in ferrets and finally discuss the suitability of ferret to model pathophysiology of various neurological diseases. 5/5
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