pathdoc3 Profile picture
30 Apr, 7 tweets, 2 min read
#COVID19 - repeated findings in medical reports:
-🦠💥Endothelial Injury
-⬆️ Vitamin D deficiency
-🥴 Immune response
-⬆️Neutrophil Extracellular Traps 🕸 (#NETs)
-⬆️ Autoantibodies, including Antiphospholipid Antibodies
-Immunothrombosis - arterial and venous⬆️blood clots🩸
🤔
-Protect endothelium
-Target vitamin D deficiency 🌞
-Target decreasing excess neutrophil extracellar traps (NETs)🕸
-Decrease likelihood of persistent autoantibodies / autoantibody titers
-Prevent blood clots 🩸
🧐”Neutrophil Extracellular Traps, Antiphospholipid Antibodies and Treatment”mdpi.com/2073-4468/6/1/…
🧐”Endothelial cell-activating antibodies in COVID-19 “medrxiv.org/content/10.110…
🧐”Conclusions: These data are the first to reveal that patient antibodies are a driver of endothelial cell activation in COVID-19 and add important context regarding thrombo-inflammatory effects of autoantibodies in severe COVID-19.”

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