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Prof. Shane Crotty Profile picture
@profshanecrotty
May 4, 2021 • 6 tweets • 2 min read • Read on X
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Oral SARS-CoV-2
I love this paper! Important demonstration of SARS2 infection in the mouth. And outstanding paper on oral biology and immunology relevant for viral infections. I learned so much! 🧵

nature.com/articles/s4159…
Really important to understand the oral biology of SARS2 better. Including salivary glands!
Clear infection of multiple oral cell types, with cells of the salivary glands of particular note because of their production of saliva.
And complex immune cell infiltrates in the salivary glands of acute COVID-19 patients, as well as autopsies. Including T cells, B cells, and antigen presenting cells.
(I am catching up on my COVID reading)

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More from @profshanecrotty

Prof. Shane Crotty Profile picture
Oct 4, 2022
Our new paper is out showing T cell responses to the Novavax vaccine, studying Novavax vaccine clinical trial participants, led by the outstanding Dr. @CModerbacher! With a nice commentary article by @PC_immuno . 🧵

jci.org/articles/view/…

jci.org/articles/view/…
This complements our immune memory study comparing 4 COVID vaccines, including Novavax.
Including direct CD4 and CD8 T cell memory comparisons

sciencedirect.com/science/articl…
Read 4 tweets
Prof. Shane Crotty Profile picture
Sep 26, 2022
Our paper on immunization and long germinal centers is out in @Nature! Congrats to the indefatigable and brilliant JH Lee and @harrysutton93 ! 🧵
nature.com/articles/s4158…

And Free link: rdcu.be/cV2xv
We put together an extensive tweetorial of this study earlier:
And a deep dive into some of the cool immunological questions the experiments shed light on:
Read 6 tweets
Prof. Shane Crotty Profile picture
Aug 31, 2022
The brand newly approved COVID boosters are going to work well. They won’t be a game changer—won’t prevent all infections—but are the best booster option and will provide a lot of protection.

It’s the immunity you want heading into the Fall and winter.

nytimes.com/2022/08/31/wel…
To clarify a few things and add some details:

The Omicron booster vaxs are clearly safe. Billions of Covid mRNA vax doses have been given, with excellent safety. Regarding the new “bivalent” boosters, there was a 2021 bivalent COVID booster vax human trial…
and it was safe and boosted immunity well. nature.com/articles/s4159…
Read 9 tweets
Prof. Shane Crotty Profile picture
Jul 28, 2022
Wonderful workshop on Vaccine Durability questions today and yesterday with NIAID. Thanks to my session co-chair @TheBcellArtist, and the awesome panelists. There was intensive and wonderful discussion, and we did make several recommendations 👇🏼
The awesome panelists were @deeptabhattacha @KingLabIPD, Rama Amara, Kanta Subbarao, and Chris Chiu (are they on Twitter?)

The rapid fire recommendations at the end of the discussion:
What kind of studies that would bring us closer to addressing some of the knowledge gaps in engineering durable vaccine immune responses?
Read 10 tweets
Prof. Shane Crotty Profile picture
Jul 19, 2022
It is good to see Novavax antibody data on Omicron 1,2,4 and 5 from @veeslerlab out. science.org/doi/10.1126/sc…
We provided the 2x Novavax immunized donor samples, which we extensively compared to mRNA and J&J vaccines for immune memory antibodies, CD4 T cells, CD8 T cells, and memory B cells in a recent paper sciencedirect.com/science/articl…
And it is good to see a new preprint from Penny Moore and colleagues with similar Novavax Omicron data.
Read 4 tweets
Prof. Shane Crotty Profile picture
Mar 31, 2022
What parts of the immune system are protecting you against COVID? Immunology is complicated, so here's a graphic to try and explain it.
Layered defenses against SARS-CoV-2, or the “Swiss cheese” model of immunity. Image
Multiple types of adaptive immunity with diverse mechanisms likely provide layers of defense against COVID-19. Conceptually, these are like a “Swiss cheese model”: even though each layer is imperfect, together they keep the pathogen from breaching all layers of defense.
The graphic was inspired by the fantastic masking and public health layered defenses Swiss cheese model of @MackayIM.
Read 8 tweets

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