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Eric Topol Profile picture
@EricTopol
May 5, 2021 • 7 tweets • 5 min read • Read on X
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Most important new report today, and highly encouraging: Real world vaccine effectiveness (E) in >380,000 people in Qatar to B.1.1.7 (UK) and B.1.351 (South Africa) variants, *100% E vs severe illness both*👍 @NEJM
nejm.org/?query=feature… Image
Text and Extended Table
1. One dose is not sufficient, especially B.1.351 which has a significant immune evasion property (most of all variants to date)
2. E vs infection of any type (PCR +) very solid 75% for B.1.351 ImageImage
Updating the evidence table for the essential point that we have vaccines that provide protection against all variants Image
Reposting the recent @nytopinion essay about having confidence in our ability to combat the major variants with vaccines and not mixing them up the multitude of scariants
nytimes.com/2021/04/13/opi… Image
Also published today is the @Novavax randomized trial data in South Africa, confirming 50% efficacy vs B.1.351 with genome sequencing nejm.org/doi/full/10.10…
(Now 3 effective vaccines, J&J, mRNA/Pfizer and Novavax vs the variant w/ highest level of immune evasion) Image
Link for the @qatar report, first in the thread
nejm.org/doi/full/10.10…
Coverage on this good news by @EmilyAnthes
nytimes.com/live/2021/05/0… "incredibly effective"
Links also to report on the 40 participant study with the @Moderna booster vaccine against B.1.351 @apoorva_nyc ImageImage

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More from @EricTopol

Eric Topol Profile picture
Apr 13
Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is favorably affected by exercise and likely many other lifestyle factors.
Here’s (almost) everything we know about it. In Ground Truths (link in my profile d/t X-suppression)Image
Here's the response to exercise Image
The most sensitive and accurate biomarker to date Image
Read 5 tweets
Eric Topol Profile picture
Apr 5
A major @Nature paper this week found a significant decline in dementia after an outdated Shingles vaccine.
I've reviewed the study and many other relevant ones in a new Ground Truths (link in profile) Image
A Table from the post Image
The effect in the 2 natural experiments differed substantially by sex with the benefit predominant in women Image
Read 5 tweets
Eric Topol Profile picture
Apr 2
The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence
"implications are profound"
New @Nature
nature.com/articles/s4158…
nature.com/articles/d4158…
Accompanying @NatureNV nature.com/articles/d4158…
Read 4 tweets
Eric Topol Profile picture
Mar 24
Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome🧵 @NatureMedicine Image
These are the specific foods that were linked with healthy aging and other outcomes. Green-favorable; Red-unfavorable Image
Adherence to these diets (most to least in quintiles) linked to healthy aging Image
Read 4 tweets
Eric Topol Profile picture
Feb 3
A paper on microplastics accumulating in the brain was just published @NatureMedicine, open-access
I review the background and major implications in a new Ground Truths edition (link in my profile)nature.com/articles/s4159…Image
Image
The human brain:
—had 7-30 times more accumulation of microparticles (MPs) than the liver or kidney (organs with previously documented high propensity)
—from people with dementia had 5X accumulation of MPs compared with non-dementia
—there was a marked increase of accumulation over recent years
Your Health Alert washingtonpost.com/climate-enviro…Image
Read 4 tweets
Eric Topol Profile picture
Dec 31, 2024
Three new @NEJM reports on #H5N1 today
1. An overview by @MichaelGIsonMD and @DrJeanneM
"urgent need for vigilant surveillance of emerging mutations and assessment of the threat of human-to-human transmission" Image
Image
2. Report of the 13-year-old Canadian girl who developed acute respiratory failure. Sequence of her H5N1 revealed 3 mutations that may be linked to higher virulence and adaptation to human cell binding Image
Image
3. Review of 46 cases of mild H5N1 illness by CDC in 2024 Image
Read 6 tweets

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