Eric Topol Profile picture
May 5, 2021 7 tweets 5 min read Read on X
Most important new report today, and highly encouraging: Real world vaccine effectiveness (E) in >380,000 people in Qatar to B.1.1.7 (UK) and B.1.351 (South Africa) variants, *100% E vs severe illness both*👍 @NEJM
nejm.org/?query=feature… Image
Text and Extended Table
1. One dose is not sufficient, especially B.1.351 which has a significant immune evasion property (most of all variants to date)
2. E vs infection of any type (PCR +) very solid 75% for B.1.351 ImageImage
Updating the evidence table for the essential point that we have vaccines that provide protection against all variants Image
Reposting the recent @nytopinion essay about having confidence in our ability to combat the major variants with vaccines and not mixing them up the multitude of scariants
nytimes.com/2021/04/13/opi… Image
Also published today is the @Novavax randomized trial data in South Africa, confirming 50% efficacy vs B.1.351 with genome sequencing nejm.org/doi/full/10.10…
(Now 3 effective vaccines, J&J, mRNA/Pfizer and Novavax vs the variant w/ highest level of immune evasion) Image
Link for the @qatar report, first in the thread
nejm.org/doi/full/10.10…
Coverage on this good news by @EmilyAnthes
nytimes.com/live/2021/05/0… "incredibly effective"
Links also to report on the 40 participant study with the @Moderna booster vaccine against B.1.351 @apoorva_nyc ImageImage

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More from @EricTopol

Apr 26
The FLiRT variant KP.2 begins its takeover for Covid cases in the US, now accounting for 1 in 4 cases
covid.cdc.gov/covid-data-tra…
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I've reviewed the FLiRT variants and their implications in a Ground Truths (link in profile) Image
The 2 mutations in the spike that account for KP.2's rise to dominance, compared with the JN.1 variant which has prevailed for months Image
Read 5 tweets
Jan 22
Breaking down the risks and benefit for lecanemab, the amyloid beta-directed antibody vs Alzheimer's drug approved @US_FDA last year. It doesn't look good.

@AnnalsofIM acpjournals.org/doi/10.7326/M2…
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A new systematic review of these antibodies looks even worse @AnnFamMed doi.org/10.1370/afm.30…



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Fixed link for this important paper
annfammed.org/content/22/1/5…
Read 4 tweets
Jan 4
My oped on the JN.1 variant and the 2nd biggest US wave of infections (after Omicron) since the pandemic began
@latimes @latimesopinion #LongCovid latimes.com/opinion/story/…
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Recent @CDCgov #SARSCoV2 wastewater data for current wave (vs Omicron Jan 2022 and subsequent waves), graph by @luckytran Image
Sorry, @washingtonpost, but this is not "another Covid-19 uptick" as you put it in your Health Alert. You ignore the best metric for infections that we have at present—wastewater—focusing only on hospitalizations
washingtonpost.com/health/2024/01…
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Read 4 tweets
Nov 23, 2023
3 New #LongCovid reports
1. Vaccination protection—1 dose 21%, 2 doses 59%, 3 doses 73% among ~590,000 people in Sweden (strong association)
bmj.com/content/383/bm…
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2. 3-year prospective follow up of a cohort of ~1350 participants, hospitalized in China
—Lung function restored back to baseline in most
—Higher risk of reinfection that people w/o Long Covid
—Half w/ persistent symptoms
thelancet.com/journals/lanre…
3. At @RSNA annual meeting, brain MRI with microstructure imaging (DMI), participants with #LongCovid vs controls had microstructure changes associated with impaired cognition, sense of smell and fatigue
eurekalert.org/news-releases/…
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Read 6 tweets
Aug 25, 2023
Big news #ESC2023 and @NEJM
In a placebo-controlled randomized trial of people with obesity + heart failure (with preserved ejection fraction). semaglutide (Wegovy) markedly improved symptoms, exercise time, reduced inflammatory markers (and weight loss)
nejm.org/doi/full/10.10…

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This also tells us something about the underlying mechanism of heart failure with preserved EF—metabolic dysfunction and attendant systemic inflammation—not previously acknowledged or confirmed
The accompanying editorial lays this finding out well. Prior studies of weight loss didn't help HFpEF
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Read 4 tweets
Aug 21, 2023
Two new papers @NatureMedicine and @JAMAInternalMed shed light on #LongCovid at 2-years. But there's no shortage of known unknowns.
Reviewed in a new Ground Truths (link in my profile, because that would be it X-suppressed) Image
Links to the new reports
@NatureMedicine by @zalaly and colleagues
@JAMAInternalMed nature.com/articles/s4159…
jamanetwork.com/journals/jamai…
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@NatureMedicine @zalaly @JAMAInternalMed Summary of previous 2-year Covid follow-up studies Image
Read 5 tweets

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