Just leaving this here:
AYUSH 64 is an old formulation that was first tried in malaria and failed to show benefit compared to standard treatment. It was commercialised in 2014 by selling rights to Dabur and is being heavily promoted without any scientific evidence..
Abstract for the phase 2 trial in patients with Vivax malaria. No subsequent larger trials done..
Reason why it's being repurposed for covid-19?
Simple: Helpless ministers don't have any idea what to do. They failed to arrange hospital beds or oxygen or ventilators or health capacity, so what else is left? You got it: promote pseudoscience BS.
Disdain for science, nay, the utter contempt for science is what got us here in the first place and it is clear that lack of scientific temperament in the current administration means many more lives will be lost while they promote this quackery!
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So, I suspect most don't really get what the big deal is in not reporting the primary outcome of a trial before commencing the trial, so here's a short #tweetorial..
So, let's say you're a competitor in a shooting contest, how do you measure your success? That's right - a target
Similarly, in clinical trials one starts with a target - aka primary endpoint. Generally this is the outcome of the trial you want to measure. These outcomes differ based on the kind of trial being planned. E.g. if we were planning a heart failure trial, some outcomes we might..
To those who have recovered from covid and are eager to share their experience:
PLEASE try not to make it into a promotion for a particular drug or treatment regimen
I've seen too many tweets that read "Doctor gave me this drug and in 5 days I was fine!"
This can be dangerous..
Your individual experience may mislead others to think that it's a simple matter of "what worked for him should work for everyone" which is not how medical science works..
As doctors we determine what works via clinical trials which have to be well designed and conducted
And we determine the best treatment approach for each individual patient based on different levels of evidence:
Why do we need to correctly count all covid deaths?
To spread doom and gloom for the sake of it? No.
Coz it's an important tool for epidemiologists? Not only that.
To deal with a problem we must first understand how bad it is..
And because it's vital for our collective memory.
It has become more and more apparent with each passing day, that the number of deaths is not only being grossly undercounted (which may be unavoidable in many cases) but that it is being SYSTEMATICALLY undercounted.
We already know from last year how many states are getting away with this: 1. Using a restricted definition to define a "covid death" 2. Excluding patients who died with comorbidities 3. Not entering covid status in death certificates 4. Not testing, restricting the criteria
Tactics used by quacks to sell their pseudoscientific concepts and 🐍 oil: 1. Modern medicine has no cure for your condition.
- Ignores the fact that some disease is incurable/beyond cure. They advertise cure but though it's been around for centuries the claims are mostly bogus.
2. No side effects! Natural is better!
- Commonly used. My prof used to say: no side effect means no effect! If it does have any effect then there must be some side effect! Biggest myth that can easily be busted, numerous examples in threads by @drabbyphilips
3. But your allopathy is full of toxic chemicals!
- Everything is a chemical, even water! Many drugs we use are actually originally from natural sources! Fact is you are much more likely to find toxic lead, arsenic and heavy metals in homeo and Ayurvedic preparations.
Ok, took me a few days to properly process the stunning results of the Delhi serosurvey. Unfortunately we only have a press conference with a few slides telling us that 22.86% of 20,000 people sampled tested positive for antibodies to Sars-cov2: timesofindia.indiatimes.com/india/almost-1…
This was done from June 27 to July 10 and they did a randomised sampling of every nth household and also sampled minors, they used the Kavach ELISA developed by ICMR (sens 92.3 and spec 97.9). The results were only recently released in the July 21st PC.
So why r these results stunning? Well, for one they imply 46 lakh infections, whereas the official count is only 1.2 lakh to date. Meaning only 1 in 38 were actually detected by antigen testing! Either implies pathetic testing or huge percentage of asymptomatics?