Where does oxalate go in the body? Research link here, looking at how "a soluble oxalate-rich diet induces stable stages of CKD in male and female C57BL/6 mice." pubmed.ncbi.nlm.nih.gov/26764204/
Two things here:
1. The oxalate source in the research was the DIET.
This is not genetic hyperoxaluria. In genetic hyperoxaluria, the oxalate is being made by the body. This is also called "endogenous" oxalate production.
1. The oxalate source in the research was the DIET.
This is not genetic hyperoxaluria. In genetic hyperoxaluria, the oxalate is being made by the body. This is also called "endogenous" oxalate production.
2. Oxalate affects the lab animals SYSTEMICALLY. From the abstract: "Within 3 wk, the mice reproducibly develop normochromic anemia, metabolic acidosis, hyperkalemia, FGF23 activation, hyperphosphatemia, and hyperparathyroidism." None of that is good news.
Further, oxalate can affect heart health. "[T]he model [of induced hyperoxaluria] is characterized by profound arterial hypertension as well as cardiac fibrosis that persist following the switch to a control diet." Note that last part - persists AFTER the switch to control diet.
If cardiovascular disease is one of our biggest killers, perhaps we should be looking at how those who eat "healthy" and yet get CVD could be the canaries in the coal mine. What if a healthy diet is good - but high oxalate in that healthy diet is potentially very bad?
@threadreaderapp unroll please
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