Italy: study linking vaccine registry (began Dec 27) & Covid-19 surveillance; 7.37m vaxed people up to Apr 4, when 65% had received 1 dose of BNT-Pfizer (Comirnaty). Here you see how they compare to everyone vaxed to date (VaxZevria=AZ, Janssen=J&J)...1/n
...This is how many had 1 or both doses in the study, compared to whole of Italy in early May: blue = fully vaxed, maroon = 1 dose. No one has had a second dose of AZ vaccine, but most people with mRNA fully vaxed.
And here's the link to the report epicentro.iss.it/vaccini/pdf/re… ..2/n
..There's no control group in this study or breakdown by region/context for the pandemic, so before we look at what happened to Covid-19 diagnoses in vaccinated people, here's Covid-19 diagnoses in Italy across the same time (from Our World in Data) ourworldindata.org/coronavirus ...3/n
...After the heartbreak of what happened in northern Italy last year, it's particularly wonderful to see this: the ratio of Covid-19 diagnoses from 0 days from the first dose of vax, in different age groups (anni = years of age) ...4/n
... Hoping someone who speaks Italian fact-checks this! 🙏 ... 5/n
...Ratio of Covid-19 diagnoses in the 2 first priority groups (healthcare workers on the left), BNT-Pfizer vax ...6/n
...Ah - they do have calculations that adjust for regions, but that's out of my league to decipher in Italian ...7/n
...From 35 days after the 1st dose (= fully vaxed for the people getting mRNA)
- Reduction in diagnoses: 80%
- Reduction in hospitalization: 90%
- Reduction in deaths: 95%
FDA report on the Novavax vaccine questions whether there's a causal relationship for myocarditis/pericarditis after the vax. This 🧵digs into their report, the Novavax response & submission, & rollout data... (1/8)
...FDA report on Friday lists 6 cases in vaxed arms of 2 trials, 4 of which don't have a specific possible alternative cause identified. This was versus 1 in placebo (not injection-related). The 2 trials had ca 27,000 vaxed participants... fda.gov/media/158912/d…
...FDA report expressed concern because a pre-marketing database of ~40,000 had more potential cases, & this hadn't been a pre-marketing safety signal for mRNA vaccines: so to them it raised Q if it could be higher for this vax than for mRNA vaxes...
#tbt This is Toshiko Yuasa, the first woman physicist from Japan. It's 1940 & with her science prospects at home blocked by gender prejudice, she'd managed to get into wartime Paris to do physics research... en.wikipedia.org/wiki/Toshiko_Y…
...The drawcard in Paris was Marie Curie's daughter, Irène Joliot-Curie & her husband Frédéric. Yuasa was inspired by their papers on artificial radioactivity.
Here's Toshiko & Irène at the Joliot-Curie home in 1941... en.wikipedia.org/wiki/Ir%C3%A8n…
...Yuasa was born in downtown Tokyo in 1909, the next-to-youngest of 7 children. Her mother came from a long line of poets, in the family of a renowned 19th century scholar, Tachibana Moribe. Her father was an engineer & inventor who worked at the patent office...
When it hit me that I knew nothing about early women scientists in Ukraine, I went down a mind-blowing rabbit hole...
So hard to pick, but I whittled down to 15 amazing stories of women born before WWII.
Today, part 1, with the first 5 women 🧵 @PLOSabsolutelymaybe.plos.org/2022/04/27/ear…
...This is Maria V. Pavlova (1854-1938), at her desk in the 1920s with fossils. She corrected an error in assumptions about the ancestry of horses...
...Sofia Okunevska-Morachevska (1865-1926) was an activist doctor - the 1st medically qualified woman in the Austro-Hungarian empire, not just Ukraine....
Such terribly sad news: the loss of Chris Del Mar, a giant of the Australian – and global – evidence community.
💔 for Tammy & family.
You'll hear a lot about this wonderful, lovable person & his amazing life ....
...Here's a quick overview from late last year, when Chris was awarded the Order of Australia - one of my faves because of the lovely family photo.... www1.racgp.org.au/newsgp/profess…
...I want to add to the remembrances & accolades for Chris, memories of a specific stream of his life - patient empowerment. From back in the early 2000s when we used to use this photo. He was the Chair of the Board of the consumer health information NGO I headed back then...
1st Covid human challenge trial results shows it is feasible: 34 people were inoculated with a very low dose. It was enough to infect 18 people (53%) & 89% of them developed symptoms ...🧵 researchsquare.com/article/rs-112… HT @HelenBranswell
..Viral shedding quantifiable within 40 hours. They concluded up to 44% of infections would happen before virus can be detected. Results support 10-day isolation periods & professionally-administered LFA/RAT was "highly reliable in predicting the disappearance of viable virus"...
...The people were 18-29 years old, & stayed in individual negative pressure quarantine rooms. No safety signals in these first 28 days of follow-up. (They'll follow them for a year)...
Great relief: it's a critical vax for the COVAX supply. Protein subunit vax, with a Dynavax adjuvant & alum. Records on it: zotero.org/groups/2528572… ...1/n HT @lutl88
...The trial has 30,128 participants in Philippines, Brazil, Colombia, South Africa, Belgium. All infections sequenced were variants. Because of vax programs in these countries, not many older people...2/n
...For people without previous SARS-CoV-2 infection, 207 tested positive & 146 of these sequenced so far. 73% were Delta (most of them), Mu, & Gamma...3/n