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Gurleen Kaur, MD Profile picture
@Gurleen_Kaur96
May 17, 2021 • 8 tweets • 7 min read • Read on X
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Essentials of Stable Ischemic Heart Disease

♦️Plaque Characteristics & Progression
♦️Choosing From Imaging Toolbox
♦️Perils of Polypharmacy
♦️Who & When To Revascularize
♦️Overview of Guidelines

🧵on this great @ACCinTouch session from today #ACC21 #ACCMedStudent
1/Plaque Progression #ACC21

Non-atherosclerotic intimal lesions➡️progressive atheroscl. lesions (fibroatheroma)➡️lesions w/ acute thrombi

Plaque rupture = lesion growth
Lumen area maintained till 40% narrowing
Narrowing beyond 40% occurs w/ plaque rupture+intraplaque hemorrhage
2/Plaque Characteristics #ACC21

Coronary artery calcification begins as micro-calcification➡️fragment➡️sheet➡️nodular

Stable plaque?
🔸Associated with DM, HTN, smoking
🔸Most common is fibrocalcific plaque (mostly sheet Ca)

Unstable plaque is mostly fragmented Ca
3/Imaging in SIHD #ACC21

Guided by pre-test risk score
-Diamond-Forrester overestimates disease
-CAD consortium more aligned w/ prevalence of obstructive CAD

Low risk➡️defer testing or stress ECG
Intermediate risk:
Anatomic-CCTA, FFR CT
Functional-stress echo/CMR, SPECT/PET MPI
4/ CCTA-📈neg predictive value, limited specificity
FFR CT-functional assessment,🚫efficient

Stress Echo-widely available, higher event rate in normal studies
SPECT- ischemia/infarct quant

🚫widely available:
Stress CMR-high resolution scar assessment
PET-superior dx accuracy
5/Polypharmacy #ACC21

Guidelines recommend many meds
Risk of adverse drug events📈w/ more meds

Approach to prioritizing pills
♦️Reduce mortality (vs. softer composite endpoints)
♦️Greater absolute reductions/lower NNT (vs. RRR)
♦️One a day dosing
♦️Consolidate whenever possible
6/Revascularization #ACC21

COURAGE, BARI2D, and FAME2:🚫benefit (death/MI) w/ revasc in angiographically selected pts w/ chronic stable angina
🌟Benefit noted in higher-risk pts

ISCHEMIA: no benefit w/ revasc for CV outcomes, but 📈QOL in pts w/ frequent angina at baseline
7/ Guidelines #ACC21

ACC/AHA guidelines are from 2012
2019 ESC⤵️6 step approach
-New focus on process of chronic coronary syndrome instead of stable CAD
-Emphasis on anatomic over functional imaging (CCTA as initial test for diagnosing CAD, but functional can further guide)

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More from @Gurleen_Kaur96

Gurleen Kaur, MD Profile picture
Jul 23, 2023
1/ Strategies for medical management of obesity, presentation by @BevTchangMD #ASPC2023

Currently 5 meds FDA-approved for long term management of obesity ⤵️ Image
2/ Who is eligible for anti-obesity medication❓

🫀 BMI >= 30, BMI>=27 with weight related comorbidity
🫀For Asians, BMI>=25-27, BMI>=25 with weight-related comorbidity

#ASPC2023 Image
3/ Efficacy‼️

Expectation of response rate: >5% weight loss over 1 year

Phen/top: 10% weight loss, 70% response rate

Semaglutide: 15% weight loss, 86% response rate

Tirzepatide: 20% weight loss, 90% response rate

#ASPC2023 Image
Read 6 tweets
Gurleen Kaur, MD Profile picture
Jan 19, 2023
1/ Cardiac Stress Testing @CardioNerds
🔶Indications
🔶Types - Exercise vs. Pharmacological
🔶Compare & Contrast Modalities

Thanks to @SimratKaurMD, @AmitGoyalMD, @jholtzman3 for feedback on this infographic!

Follow🧵for a breakdown of the graphic⤵️
2/ Indications

Evaluate:
🔺Stable chest pain in pts w/ intermediate-high risk of CAD
🔺New onset symptoms in pt w/ known CAD
🔺Valvular heart disease & provocative testing in HCM
🔺Microvascular disease & CAV in transplant pts
🔺Hibernating myocardium in pts w/ known CAD
3/ Types❓Exercise vs. Pharmacological

🏃‍♀️Exercise
What➡️Treadmill
Who➡️ Anyone who can exercise (achieve 4 METs) and get to 85% of max predicted HR (220-age)

When evaluating report, look for:
🌟Duration of exercise
🌟METs achieved
🌟% max HR
🌟HR/BP response
Read 12 tweets
Gurleen Kaur, MD Profile picture
Nov 16, 2022
1/ In Episode 234, @PaChapterACC & @CardioNerds featured a Narratives in Cardiology discussion on Structural Heart Disease & LatinX Representation in Cardiology w/ @MayraGuerreroMD, @TDonisan, @AdrianaCMares

Follow this #CardsNarratives 🧵 on Valvular Heart Disease in Women Image
2/ We’ll cover these 2 questions:

❓What are the disparities in valvular heart disease in women?
❓What changes need to be implemented to improve the care of women with valvular heart disease?
3/ I feel comfortable openly discussing or asking others about factors that make them different from myself like race, religion, ethnicity, gender, sexual orientation, immigration status, etc
Read 12 tweets
Gurleen Kaur, MD Profile picture
Aug 30, 2021
1/ In the🥉@PaChapterACC & @CardioNerds Narratives in Cardiology episode @mirmerrill, @scfuentesr, and @NatashaCuk talk w/ @KTamirisaMD

Follow this #CardsNarratives🧵on the discussion about gender equity & women in Cardiology/Electrophysiology (EP)
2/ We'll cover these 3 questions:

🔸Why should we promote gender diversity in Cardiology/EP?
🔸How do we address barriers for women in Cardiology/EP?
🔸What are some opportunities for EP in private practice?
3/ I feel comfortable openly discussing or asking others about factors that make them different from myself like race, religion, ethnicity, gender, sexual orientation, immigration status, etc
Read 20 tweets
Gurleen Kaur, MD Profile picture
Jul 25, 2021
1/ Day 3 & last session of #ASPC2021 on special populations

Talk on MI & HF among people with HIV by Dr. Markella Zanni

Follow this🧵on:
🔹MI risk in people w/ HIV
🔹HF in PWH
🔹CVD preventive approaches tailored to people w/ HIV

@ASPCardio @CardioNerds
2/ Patients with HIV are now living longer ➡️increased risk of CVD

Global burden of atherosclerotic CVD in people living with HIV has tripled over past 2 decades

Relative risk of MI is 1.5-2 in high-income countries

pubmed.ncbi.nlm.nih.gov/23459863/

#ASPC2021
3/ From US Partners database study – adjusted relative risk for MI was around 3 for women & 1.5 for men – regionally specific

Type 1 vs. type 2 MI: both ~50%
Women – more type 2 MI

pubmed.ncbi.nlm.nih.gov/17456578/

#ASPC2021
Read 18 tweets
Gurleen Kaur, MD Profile picture
Jul 24, 2021
1/ #ASPC2021 talk for Honorary Fellowship Award by @NMHheartdoc on New Kind of Prevention – Reducing CV Health Disparities at Community and Individual Level

🧵from session

@ASPCardio @CardioNerds
2/ #ASPC2021
Covid-19 deaths by race and ethnicity in the US:
1 in 555 Black Americans has died

Populations w/ highest disease burden➡️ lowest vaccination rates
3/ Any discussion of prevention shouldn’t start at hypertension, dyslipidemia, but at the root cause of those inequities.

Need to address policy. All policy is health policy.

Stolen breaths nejm.org/doi/full/10.10…

#ASPC2021
Read 10 tweets

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