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Shane Crotty Profile picture
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21 May, 7 tweets, 2 min read
My current take on RNA vaccine likely protection against B1617 (Indian variants)

nbcnews.com/health/health-…
“The fact that there is real-world data that shows the Pfizer vaccine works very well against the South African variant, it's quite likely that both the Pfizer and Moderna vaccines will be very effective against these new Indian variants, as well,”
That is based on:
🔵 data from Qatar against B1351 (97% protection against severe disease, 75% against infection)
🔵@SutharLab B1617 neutralizing Ab data
🔵L452R containing CAL.C20 variant antibody data
here
and here
and here
medrxiv.org/content/10.110…
And @GuptaR_lab neut data too

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More from @profshanecrotty

Shane Crotty Profile picture
22 May
Vaccination of immunocompromised or immunosuppressed people against COVID is a major topic now.
I think this is good simple advice:
"Get vaccinated, but behave as though you're not," Dorlan Kimbrough, a neurologist who treats multiple sclerosis patients at Duke. 🧵
It is early days for understanding and advice on this, but thankfully there are already scientific studies (preprints) being published on COVID vaccine immune responses in such patients. These are two good new news articles on the topic:
advisory.com/en/daily-brief…
and
washingtonpost.com/lifestyle/2021…
Read 11 tweets
Shane Crotty Profile picture
20 May
My comments on an excellent new study on delaying the 2nd dose of Pfizer COVID vaccine to 3 months, in people over 80. 🧵

A well done story by local journalist @DerekStaahl.

10news.com/news/in-depth/…
Overall, this new delayed dose vaccine study it is a high quality study. Bottom lines: 
🔵 The UK delayed vaccination is working for them, and allows vaccination of more people. And the new data support that. I am really happy about that!
🔵 But, if you have enough doses, getting the 2nd dose on the recommended schedule is still probably better.
Read 10 tweets
Shane Crotty Profile picture
12 May
For people on the fence about getting the COVID-19 vaccine for their kids, given the approval today, here is COVID-19 vaccine information. 🧵
1/ Kids get COVID-19, including very serious disease.

There were over 35,000 kids hospitalized with COVID-19 in America this past year.

Among pediatric hospitalization cases, 50% had no risk factors.

covid.cdc.gov/covid-data-tra…
2/ The vaccine is incredibly successful in kids 12-15, and very safe
Read 4 tweets
Shane Crotty Profile picture
11 May
The FDA expanded the Pfizer/BioNTech RNA COVID-19 vaccine to 12-15 year olds yesterday.
🔵Excellent protection (100% = 0 cases versus 18)
🔵Excellent safety (On to younger children already)
🔵Better antibodies than adults

Also bodes well for other COVID vaccines in kids!🧵
FDA CBER head Dr. Marks:"It was a relatively straightforward decision. The response..was excellent and in fact it was even better, really, in the younger age group than it was in the 16-25 age group. The safety profile was very similar in 12-15-year-olds as in 16-25-year-olds."
fda.gov/news-events/pr…
Read 8 tweets
Shane Crotty Profile picture
6 May
Moderna results are out for their booster vaccines!
🔵 Boosting with same vaccine generates good antibodies against variant B.1.351
🔵 Boosting with a B.1.351 vaccine generates even better antibodies
🔵 Safe
🔵 The booster vaccine was made and tested with exceptional speed!
🧵
The reason for excitement about this is that there has been uncertainly for months about vaccine efficacy against B.1.351 (1st seen in South Africa) and similar variants. Since January I have been saying:
Moderna, Pfizer, J&J and other vaccine companies have all stated that they are developing B.1.351 boosters or similar. Today is the first public data on such a vaccine.

investors.modernatx.com/news-releases/…
Read 8 tweets
Shane Crotty Profile picture
5 May
Big knowledge gap was will the COVID RNA vaccines work vs B.1.351 and P.1 variants. Now Pfizer protects well vs B.1.351!
🔵 ~75% against infection
🔵 ~97% against severe/fatal disease

Very good news for the rest of 2021 for any countries using Pfizer and Moderna vaccines! 🧵
B.1.351 and P.1 (1st found in South Africa and Brazil) have been the two biggest variants of concern that have a degree of antibody escape. As of this morning (and February), some vaccines (AZ) showed only 11% effectiveness against B.1.351 cases,
and the best clinical trial data was ~50-66% vaccine efficacy against B.1.351 cases (J&J and Novavax), and only data for non-hospitalized cases (because of the size of the studies). Leaving lots of uncertainty.
Read 12 tweets

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