First session at #ATTD2021. As a honeymooning T1D LADA who takes a GLP-1RA to help preserve my beta cells, I'm interested to see what's new with these "Great Little Peptides" #dedoc° @ATTDconf Image
If you are unfamiliar with GLP-1RAs, get the cliff notes here: practicaldiabetic.com/2020/10/10/the… #dedoc° #ATTD2021
The talk is about the oral version of Semaglutide which was also discussed at the EASD2020 conference last year. Many may be familiar with the injectable form which is sold under the name Ozempic. #dedoc° #ATTD2021
The session is promoting the benefits of Semaglutide (Ozempic) over other similar drugs such as Sitagliptin. This research from the Pioneer study was the reason I asked my Endo about switching from Trulicity to Ozempic. #dedoc° #ATTD2021
They haven't shown the adverse events for the different doses of semaglutide but this was shown at EASD2020 last year and is attached here for anyone who is curious and also available, along with a lot of the other Pioneer results here practicaldiabetic.com/2020/10/10/the… #dedoc° #ATTD2021 Image
One of the benefits they are talking about with Semaglutide is weight loss. I can testify to this. I've lost around 10kgs (22 pounds) on Ozempic (the injectable form of the medication) and seen benefit in terms of my HbA1c and insulin resistance. #dedoc° #ATTD2021
They're now talking about the common effect of nausea with Semaglutide. I get mild nausea the day after injecting Semaglutide similar to mild car sickness but find a small snack (like water crackers) addresses it quite quickly. #dedoc° #ATTD2021
Great quote from @estebanjodar "We don't treat diseases, we treat patients with diseases". Something all health care professionals need to remember ;) #dedoc° #ATTD2021

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More from @PracticalDeeb

4 Jun
Advances in Closed Loop conclusions:
- A more aggressive target improves Time in Range (79% achievable) but does not increase Time Below Range
- Improvements, especially in younger adults when compared to open systems
- Closed Loop is safe.
@ATTDconf #ATTD2021 #dedoc° Image
Moreover, it is as safe for children as adults. #ATTD2021 #dedoc° Image
Results not exclusive to Medtronic. Omnipod shows similar results in terms of improvements over open systems #ATTD2021 #dedoc° Image
Read 6 tweets
3 Jun
The next presentation I'm in is "Artificial intelligence (AI): Tangible Applications to Improve Diabetes Care". AI has come far in the last few years and the poster I mentioned yesterday shows how it can tailor closed loop systems. What else I wonder? @ATTDconf #ATTD2021 #dedoc°
Stephane Bidet is saying with as little as 10 days of data, the AI can be trained effectively to smartly manage the user's BGLs. I believe it. Microsoft's Azure AI can effectively read forms with just 5 examples and images with 15 examples. #ATTD2021 #dedoc°
Knowing the likely error in the predictions made, this variance is then used to ensure safe recommendations are made. This is smart. It will slightly hamper accuracy but ensure super-high or super-low BGLs do not happen. #ATTD2021 #dedoc°
Read 6 tweets
3 Jun
With Dexcom being at the forefront of pumps and CGMs I'm hoping for something special in this one. @ATTDconf #ATTD2021 #dedoc° Image
Control IQ gave users 2.6 hours additional Time in Range over "Sensor Augmented Pumps" (open loop pump therapy) #ATTD2021 #dedoc°
The number of people getting a Time in Range over 70% tripled with Control-IQ over the open loop therapy group. For long term complication management, this is a great result. #ATTD2021 #dedoc°
Read 10 tweets
2 Jun
Next is a presentation on Smart Pens for diabetes management @ATTDconf #ATTD2021 #dedoc°
The research specifically refers to the Novo Nordisk NovoPen 6 but I'll try to keep it general. #ATTD2021 #dedoc°
The NovoPen has a five year battery which is impressive in comparison to the Medtronic InPen which only lasts 1 year and the battery cannot be replaced.
#ATTD2021 #dedoc°
Read 6 tweets
2 Jun
Next is Medtronic talking about the outcomes for the first 4,000 users of the MiniMed 780G and the future for this commercial looping system. It will be interesting to see how it stacks up to the homegrown systems. @ATTDconf #ATTD2021 #dedoc°
Dr Chantal Mathieu makes the point that the patient living with diabetes gets a few more hours with the disease than their health care team ;) #ATTD2021 #dedoc° Image
Time in Range for the 780G was similar across the multiple countries involved in the analysis suggesting there was no bias from country-specific factors. #ATTD2021 #dedoc°
Read 7 tweets

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