Thread by @MonicaGandhi9

NOVAVAX trial from this morning: First want to remind you that we have 9 vaccine candidates out there, 6 of which involve the spike protein in some way (Novavax actually gives the spike protein + an adjuvant) and 3 of which are whole inactivated virions. Table below

Here is our clinical trial data for the 6 spike protein vaccines (will summarize Novavax in moment as the phase 3 trial called PREVENT-19 came out today) and the next tweet shows the phase 3 data for the 3 whole inactivated vaccines (Covaxin, Sinopharm, Sinovac)

And here is phase 3 clinical trial data for the 3 whole inactivated vaccines. Okay, then, going back to Novavax, it is the spike protein put together with an effective adjuvant and we had a phase 2b study in S. Africa & UK study before, but PREVENT-19 was largest, results 6/14

Novavax looks very good and - unlike with previous clinical trials - could sequence breakthrough cases with vax and failures with placebo to detect for variants. Overall, 90.4% effective; ALL cases of moderate/severe disease occurred in placebo so 100% effective for this outcome

Results look amazing - of 14 cases in vaccine group, all mild. Importantly, enrolled a very diverse population, large, across sites in US and Mexico, and also with high rates of co-morbidities and older- still did well in this population, see below.

And this is variant data, works against them as expected because they ALL do (and anyone telling you variants evade vaccines are incorrect). This is a 2-dose vaccine, not mRNA or DNA but spike protein itself with adjuvant, can be stored at 24 hours room temp/6 months in fridge

sorry, here is link for Novavax's press release- I am very interested in this vaccine as mRNA vaccines not being given out worldwide at rate & generosity as hoped so this stable protein-based vax may be very helpful
ir.novavax.com/news-releases/…