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Eric Topol

@EricTopol

Jun 18, 2021 • 6 tweets • 4 min read • Read on X

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@PHE_Uk

The Delta variant: updates from the new @PHE_Uk report
assets.publishing.service.gov.uk/government/upl…
1st dose vaccine (either AZ or Pfizer) quite protective vs hospitalization
Fully vaxxed vs unvaxxed:
Infections 7.7% vs 67%
Hospitalizations 8% vs 48%

Delta's secondary attack rate is coming down some in the latest dataset. Its enhanced transmission over alpha appears to be more in the 40-60% range

Reinfections by sequencing data: 311/1260 were Delta

This 71-page report is rich. And that 60% of infections are getting sequenced (91% are Delta) is quite impressive.
It makes the output from CDC and the genomic surveillance in the US particularly weak

@CDCgov

Here is the latest @CDCgov variant report. It is from May 22 and it's frankly pathetic when you compare it to @PHE_UK, both with respect to it being out of date and the lack of sequencing in the US
covid.cdc.gov/covid-data-tra…

@PHE_UK

Contrast today's @PHE_UK report from genome sequencing (60% of cases) up to 4 days ago -- >60,000 Delta cases with vaccination status and outcomes

@scrippsresearch

Latest from @scrippsresearch's outbreak.info/location-repor…
"Changing of the Variants"

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More from @EricTopol

Eric Topol

@EricTopol

Feb 3

A paper on microplastics accumulating in the brain was just published @NatureMedicine, open-access
I review the background and major implications in a new Ground Truths edition (link in my profile)nature.com/articles/s4159…

The human brain:
—had 7-30 times more accumulation of microparticles (MPs) than the liver or kidney (organs with previously documented high propensity)
—from people with dementia had 5X accumulation of MPs compared with non-dementia
—there was a marked increase of accumulation over recent years

Your Health Alert washingtonpost.com/climate-enviro…

Read 4 tweets

Eric Topol

@EricTopol

Dec 31, 2024

Three new @NEJM reports on #H5N1 today
1. An overview by @MichaelGIsonMD and @DrJeanneM
"urgent need for vigilant surveillance of emerging mutations and assessment of the threat of human-to-human transmission"

2. Report of the 13-year-old Canadian girl who developed acute respiratory failure. Sequence of her H5N1 revealed 3 mutations that may be linked to higher virulence and adaptation to human cell binding

3. Review of 46 cases of mild H5N1 illness by CDC in 2024

Read 6 tweets

Eric Topol

@EricTopol

Dec 9, 2024

We're learning how to control the immune response, like a rheostat, even in the brain. Implications for understanding the basis and potential treatment of autoimmune conditions like multiple sclerosis, #LongCovid, #MECFS, and brain cancer.
A brief review of 6 recent, important reports
in the new Ground Truths, open-access

Such as Programming T cells with brain-specific proteins and payloads
@ScienceMagazine science.org/doi/10.1126/sc…

Or peptide fragments of myelin basic protein that suppress the immune response @Nature nature.com/articles/s4158…

Read 4 tweets

Eric Topol

@EricTopol

Nov 13, 2024

New @NEJM
A whopping (~90%) reduction of progression to Type 2 diabetes with tirzepatide (GLP-1 drug, dual receptor) vs placebo in a randomized trial of >2,500 participants with obesity, absolute reduction of 10/100 treated

by @AniaJastreboff and collaboratorsnejm.org/doi/full/10.10…

In other GLP-1 new publications today
—Country-wide Sweden reduced hospitalizations for alcohol or substance abuse with these drugs
jamanetwork.com/journals/jamap… @JAMAPsych
—Concerns about discontinuation
jamanetwork.com/journals/jama/… @JAMA_current

Other new anti-obesity drugs in the pipeline, one that also increases energy expenditure
@NatureNV nature.com/articles/d4158…

Read 4 tweets

Eric Topol

@EricTopol

Nov 13, 2024

A dedicated issue of @ScienceTM on #LongCovid
—Sex-specific differences, with perspective by @VirusesImmunity and @SilvaJ_C
—Insights for therapies @AndreaCoxMDPhD
—Deconvoluting "Osler's Web" @MichaelPelusoMD @DeeksSteven @DrMaureenHanson @SaydahSharon
—+RECOVER Trial, Lyme disease

science.org/toc/stm/16/773

Where we have failed to date: finding an effective therapy. That has to change
science.org/doi/epdf/10.11…

Read 4 tweets

Eric Topol

@EricTopol

Oct 19, 2024

An elegant @Nature study by @AkassoglouLab has illuminated our understanding of the role of fibrin (component of blood clots), #SARSCoV2, and brain inflammation in Covid and #LongCovid.
This discovery and more in the new Ground Truths podcast, with transcript, key figures (such as as the one below) and citations. Open-access. Link in my profile.

A clip from our conversation. Unknowingly, @AkassoglouLab was gearing up for understanding this complex pathophysiology for many years before Covid hit