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Eric Topol Profile picture
@EricTopol
Jun 18, 2021 • 6 tweets • 4 min read • Read on X
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The Delta variant: updates from the new @PHE_Uk report
assets.publishing.service.gov.uk/government/upl…
1st dose vaccine (either AZ or Pfizer) quite protective vs hospitalization
Fully vaxxed vs unvaxxed:
Infections 7.7% vs 67%
Hospitalizations 8% vs 48%
Delta's secondary attack rate is coming down some in the latest dataset. Its enhanced transmission over alpha appears to be more in the 40-60% range

Reinfections by sequencing data: 311/1260 were Delta
This 71-page report is rich. And that 60% of infections are getting sequenced (91% are Delta) is quite impressive.
It makes the output from CDC and the genomic surveillance in the US particularly weak
Here is the latest @CDCgov variant report. It is from May 22 and it's frankly pathetic when you compare it to @PHE_UK, both with respect to it being out of date and the lack of sequencing in the US
covid.cdc.gov/covid-data-tra…
Contrast today's @PHE_UK report from genome sequencing (60% of cases) up to 4 days ago -- >60,000 Delta cases with vaccination status and outcomes
Latest from @scrippsresearch's outbreak.info/location-repor…
"Changing of the Variants"

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More from @EricTopol

Eric Topol Profile picture
Apr 13
Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is favorably affected by exercise and likely many other lifestyle factors.
Here’s (almost) everything we know about it. In Ground Truths (link in my profile d/t X-suppression)Image
Here's the response to exercise Image
The most sensitive and accurate biomarker to date Image
Read 5 tweets
Eric Topol Profile picture
Apr 5
A major @Nature paper this week found a significant decline in dementia after an outdated Shingles vaccine.
I've reviewed the study and many other relevant ones in a new Ground Truths (link in profile) Image
A Table from the post Image
The effect in the 2 natural experiments differed substantially by sex with the benefit predominant in women Image
Read 5 tweets
Eric Topol Profile picture
Apr 2
The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence
"implications are profound"
New @Nature
nature.com/articles/s4158…
nature.com/articles/d4158…
Accompanying @NatureNV nature.com/articles/d4158…
Read 4 tweets
Eric Topol Profile picture
Mar 24
Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome🧵 @NatureMedicine Image
These are the specific foods that were linked with healthy aging and other outcomes. Green-favorable; Red-unfavorable Image
Adherence to these diets (most to least in quintiles) linked to healthy aging Image
Read 4 tweets
Eric Topol Profile picture
Feb 3
A paper on microplastics accumulating in the brain was just published @NatureMedicine, open-access
I review the background and major implications in a new Ground Truths edition (link in my profile)nature.com/articles/s4159…Image
Image
The human brain:
—had 7-30 times more accumulation of microparticles (MPs) than the liver or kidney (organs with previously documented high propensity)
—from people with dementia had 5X accumulation of MPs compared with non-dementia
—there was a marked increase of accumulation over recent years
Your Health Alert washingtonpost.com/climate-enviro…Image
Read 4 tweets
Eric Topol Profile picture
Dec 31, 2024
Three new @NEJM reports on #H5N1 today
1. An overview by @MichaelGIsonMD and @DrJeanneM
"urgent need for vigilant surveillance of emerging mutations and assessment of the threat of human-to-human transmission" Image
Image
2. Report of the 13-year-old Canadian girl who developed acute respiratory failure. Sequence of her H5N1 revealed 3 mutations that may be linked to higher virulence and adaptation to human cell binding Image
Image
3. Review of 46 cases of mild H5N1 illness by CDC in 2024 Image
Read 6 tweets

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