I took and TA'ed genetics with Meselson in college. He was working on biosafety and bioweapons then, so has accumulated a lot of knowledge on the subject over decades.
"There’s a huge difference between people who are still trying to prove a point against emotional opposition and people who can look back and say, ‘Yeah, yeah, I was right,’” Dr. Meselson said.
“One of them fuels wars. The other is history. We need to get all these things solved. We need history, we don’t need all this emotion.” As sharp as ever.
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Earlier I proposed a simple public health philosophy: "identify the worst-case scenario using the most up-to-date science and recommend easy things that can mitigate that"
No claim to originality; would hope it's the default PH approach actually
10 million Americans have received the J&J vaccine. That's a big enough group for PH officials to care about. They have a vaccine with measured efficacy of ~70% for symptomatic disease and ~90% for hospitalization or severe disease (on a mix of original and alpha strains)
All good, and if we have already vaccinated >75% of people ≥12yo in the US with RNA vaccines, maybe good enough. We'd reach herd immunity, mostly due to the RNA vaccines' ~90% efficacy against all disease, i.e. R0 becomes <1.
HCWs are the last people who would criticize CDC; they must maintain an united front with CDC to limit the epidemic and make their jobs doable (+ less deadly). So this finding that trust in CDC has dropped in 77% of doctors and 77% of nurses is striking. webmd.com/lung/news/2021…
The survey doesn't reveal how complaints are distributed within the 77%, e.g. if HCWs think the CDC is being too cautious or too lenient, or just too confusing. But there's been plenty to criticize from both scientific and behavioral points of view, so it's probably all the above
The list of failures is well known, and I'm not just speaking from hindsight. These failures were identified in real-time by many on twitter (even if established media orgs obediently parroted the CDC), and it was the CDC that was slow to learn and reverse.
We usually hear only overall top-line efficacy figures of 66% against symptomatic disease and 93% against hospitalization. We also hear that in the J&J trial, there were no deaths in the vaccinated group. That's across the entire tested population. But even then, to be accurate
... there is considerable imprecision in our knowledge of how well J&J protects against more severe outcomes. The 93% protection v hospitalization has 95% confidence intervals of 73-99%. This large range is due to the small # of people actually hospitalized during the trial.
Our knowledge of protection from death is even weaker. The fact 0 vaccine vs 6 placebo recipients died is often touted as 100% protection against death, even by public health officials. This is unlikely to be the case, and scientifically inaccurate.
Stories such as this one, however well intentioned, are disingenuous and thereby harmful to trust and public health.
It's pointless to gaslight people on J&J's efficacy by pretending it's as good as RNA vaccines. People know 95% > 68% for goodness sake. theatlantic.com/health/archive…
Paragraph 1 is a no-holds barred plug for J&J extolling its virtues. One statement would be flagged by the FCC as false advertising if it were in a commercial: "It requires just one injection to confer full immunity".
Strange to write that, when it's so easily proven false.
First of all, you know that statement is going to raise eyebrows, because how much sense does it make for J&J to use an adenovirus vector to express spike and reach full immunity with 1 injection, when AZ and Gamaleya using adenovirus vectors to express spike needed 2 injections?
The Moderna multi-strain booster (mRNA-1273.211) is combines original mRNA-1273 with mRNA-1273.351 for the Beta B.1.351 variant. It's called "multivalent" which is kind of a misnomer as valency usually refers to number of binding sites, but I guess there wasn't a better term.
mRNA-1273 and mRNA-1273.351 each were already shown safe and effective in boosting neutralizing antibodies when administered as a third shot investors.modernatx.com/news-releases/…
The J&J vaccine is <10% of vaccinations in the US, and ~0% outside, so it isn't studied as much as other vax. In particular how well J&J works against Delta (b.1.617.2) hasn't been discussed, whereas we know a lot about Pfizer/Moderna/AZ. So I've decided to take a stab at it.
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2) I was motivated by this CNN article which revealed recent findings that the Pfizer/BioNTech vaccine (and likely the similar Moderna) are 88% protective against symptomatic Delta infection after dose 2 (good), but only 33% after dose 1 (not so good) cnn.com/2021/06/10/opi…
3) The article says "Of note, this variant appears to be extremely transmissible, and the first dose of a two-dose vaccine regimen is much less effective than is the first dose against other variants." What about J&J which only has 1 dose?