During the first half of the 19th century, Native American populations in the Pacific Northwest may have dropped by up to 98%: 
(This is from: publishersweekly.com/978-0-312-1698…)
One way Britain tried to dissuade Americans from colonizing the Pacific Northwest: destroying beaver populations.
Marcus Whitman on the American colonization of the Pacific Northwest: “I have no doubt our greatest work is to be to aid the white settlement of this country”
Here’s the main American official in Washington Territory threatening outright genocide against Native Americans, and specifically the Yakima, if they didn’t cede territory to the U.S.:
After American officials tracked and captured Chief Joseph’s group of Nez Percé, Washington forcibly shipped them to Oklahoma, where “at least a third of them perished”:
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