@lalani_safina @macroliter Lambda first found in Peru had the Pango lineage name of C.37. The deletion you are looking for is likely what the following paper refers to as the novel deletion Δ246-252 .

virological.org/t/novel-sublin…
@lalani_safina @macroliter Another paper on Lambda focusing on the mutation:

medrxiv.org/content/10.110…
@lalani_safina @macroliter As for the general significance of deletions...

medrxiv.org/content/10.110…
@lalani_safina @macroliter My apologies... I see that you linked to "First Identification..." in a recent tweet. While searching I found that "Lambda" C.37 is being considered for Variant Of Concern status. That would make it the fifth.
@lalani_safina @macroliter (1/2) Personally, I wonder first whether the Greek alphabet should be used for naming variants of concern and interest since it is already being used for the broad genera of coronaviruses (SARS, MERS, and SARS-CoV-2 are all betacoronaviruses, but there are also the...
@lalani_safina @macroliter (2/2) alphacoronaviruses, gammacoronaviruses and deltacoronaviruses). I also have to wonder whether we shouldn't simply be using it (of we insist on doing so at all) for just the VOCs. I think it might hold out, but if we include the VOIs it won't be that long before we hit Ω.

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More from @TimothyChase

7 Jun
@lalani_safina @giorgilab (1/n) Actually the T478K mutation is found in "Delta" B.1.617.2. as you can tell was the substitution from T to k we are looking at a neutrally charged amino acid being replaced by a positively charged amino acid which means that it will be more difficult...
@lalani_safina @giorgilab (2/n) for the immune system to create antibodies that will counteract it. However at least with the variant discovered in Mexico we found that this mutation has an especially high free binding energy to the ACE2 receptor. As such it binds much more tightly to the receptor and...
@lalani_safina @giorgilab (3/n) this likely explains much of the increased transmissibility.

Regarding Delta:

"In particular, the Spike protein contained 9
mutations, when compared to the D614G strain (belonging to the basal B.1 lineage) used here as a
reference, including five mutations..."
Read 8 tweets
25 May
(1/n) #B1617 #variants (dropping the dots for the hashtag) "... the B.1.617.2 variant has mutations called 452R and 478K, which Tang says are both linked to increased transmissibility. Both mutations alter the spike protein...."
nature.com/articles/d4158…
(2/n) [L]452R is believed to result in the spike binding more closely to the ACE2 receptor and may simultaneously result in a degree of Immune escape. From analysis of B.1.429 which has the same mutation...
(3/n) "This replacement is predicted to create a much stronger attachment of the virus to the human cells and also might allow it to avoid the neutralizing antibodies that try to interfere with this attachment." (2021 Feb 26)

newsroom.uw.edu/news/single-mu…
Read 21 tweets
28 Mar
@beuchelt @GYamey @rjar1980 (1/n) At least in the relevant physics communities among members publishing in the peer reviewed literature, the acceptance of Einstein's special theory of relativity was rapid. A matter of a few years.
@beuchelt @GYamey @rjar1980 (2/n) This was in part thanks to the efforts of individuals such as a Lorentz and Planck. And despite the complexity of his theory of gravity, it's acceptance in the peer reviewed literature was even more rapid.
@beuchelt @GYamey @rjar1980 (3/n) There were of course antisemite scientists, particularly in Germany with the rise of Nazism, but there protests were almost entirely a matter of the popular press and politics, not peer reviewed literature.

Darwin? His case is a little more interesting.
Read 16 tweets

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