The day this piece published, one of my own cats, Calvin, was diagnosed with a serious condition, likely with genetic roots, that impacts his heart function. There is no cure. We don't yet know his prognosis. I am absolutely heartbroken. 2/
We adopted Calvin and his brother, Hobbes, almost 5 years ago, to the day. Since then, they have both brought immeasurable light into my life, and have been my biggest source of comfort during the pandemic. 3/
The day we brought Calvin home, he was scared and confused and spent the entire afternoon hiding under the bed. 4/
But by the next evening, he was crawling into bed with us and curling up on my left shoulder to sleep. The vet said it was kitten behavior, he'd grow out of it. Five years later, he's a lot bigger, and my shoulder's a bit too small. But it's still his favorite spot to be. 5/
Yesterday, I rushed him to the hospital because his breathing had turned fast and shallow. Even when he was feeling at his worst, he pressed his little face to mine when I leaned next to the carrier. I wanted to give him all the comfort I could. 6/
He had to be admitted for assessment. I waited in the parking lot; I couldn't be with him or his vets because of the pandemic.
Last night was the first night I've ever had to spend in the apartment without him, while he was cared for in the ICU. 7/
Calvin is coming home today, and we'll be medicating him and caring for him from now on. I can't help but wonder where we'd be if he'd had the opportunity to be screened for this earlier, with more knowledge of feline genomics to guide us. 8/
My hope is that a better understanding of cat genetics and physiology will help other owners catch these conditions early, or at least better understand why they occur. It's a niche pursuit. But if it saves the lives of just a few animals, then it seems worth it to me. 9/9
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remember Ct values? those numbers spit out by certain types of PCR tests, including some of the ones we use to test for the coronavirus?
let's talk. 1/
Ct values correlate with how much viral RNA is in the sample. so if you're running several samples on a test platform, and some have higher Cts, those have *less* RNA (it's a reverse scale; Cts count how many times you have to copy the genetic material before it's "visible") 2/
Ct values do not tell you if the viral RNA belongs to an intact virus or an infectious virus. they also don't measure how directly "transmissible" someone is. to measure transmission, we need epidemiological data - how are *actual humans* spreading the virus? 3/
If your antibody levels drop over time... it's not the end of the world. Actually, it's what happens naturally. It's expected. It's your body being economical with its resources. 1/
Think of it this way. Antibodies are ephemeral proteins. Individual antibodies aren't built to last forever. They'll ebb after an infectious threat has passed. But the body retains the capacity to produce them. 3/
Let's first get our definitions straight. Vaccines, first and foremost, prevent *illness*, especially of the serious sort. They teach the body to rein the virus in, and keep it from running roughshod over your tissues. It's harder, though, to stop infections entirely. 2/
Remarkably, our vaccines do this in some people! That's worth celebrating, but it's the wrong goalpost to have in most cases.
That said, our vaccines are still REDUCING infection and transmission, even if they're not stamping it out. 3/
I laid out some of my thinking process for masking again indoors, in the age of Delta. This is my own personal risk calculation, but I hope it's helpful for some other folks who are puzzling this over. 2/
There's no *one right answer*—rather, everyone has to think about their own local conditions: hospitalizations, vaccination rates, variant prevalence, etc. But it would serve us all to be flexible. This pandemic isn't over. And I don't want to lose the momentum we've built. 3/
I am not an MD, so I’ll offer just this: it’s very encouraging to see federal regulators take swift action on the J&J vaccine. This is the process working as it should. If there is a true link between the vaccine and these rare clots, they will work to identify it. 1/
They may instate an age restriction, as some countries have done for the similar AstraZeneca vaccine—perhaps younger people, especially younger people who are biologically female, may end up needing to seek an alternative. But for now: these cases appear VERY RARE. 2/
So far less than 1 in 1 million. And this DOES NOT detract from the effectiveness of the vaccine, which is excellent.
If you have gotten this vaccine, keep those numbers in mind. All clots also appeared within 2 weeks of injection. 3/