If you have smoldering multiple myeloma, a type of blood disorder, you could see 4 experts and come away with 4 different options:
1) No treatment 2) Mild treatment with 1 drug 3) Cancer like treatment with 3 drugs 4) Aggressive treatment including bone marrow transplant
Of course truth is that one of the treatment options is right. But how is a patient to decide which option will provide the best quality and quantity of life? Which expert to trust?
For each patient there is one right answer and the truth is not necessarily in the middle.
The point is that complex medical problems, whether it is smoldering myeloma, or cancer, or COVID have a lot of variables that need to be considered to make the right call.
Some experts make the right call because they have the ability assess all variables. Some do so by luck.
But it may be harder to come to the right decision by consensus of experts or group think. Which is why a lot of expert consensus recommendations ends up being the lowest common denominator: the one that everyone can live with. Wishy washy.
A consensus decision could well be wrong. And if so then it has more serious repercussions because now everyone is following the wrong advise. At least when each one followed their own favorite expert at least some people by average would end up doing the right thing.
If there is a meeting of the minds it's more helpful to have perspectives from experts in various fields rather than 5 experts with similar skill sets.
I don't have answers. In my field, I go back and forth from one single expert opinion to consensus depending on the question.
But it's something I have seen over and over in this pandemic. We have examples of individual people being right on something when the collective wisdom of a consensus group of experts was wrong. So it's worth considering.
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The FDA booster dose authorization does not apply to people who are not immunocompromised.
They don't give wording to preclude J&J recipients who are severely immunocompromised from receiving the booster as far as I can tell. fda.gov/news-events/pr…
This is a good decision that helps severely immunocompromised patients. I believe myeloma patients & those with other B cell malignancies receiving monoclonal antibodies against the immune system are similarly immunocompromised as patients receiving solid organ transplants.
Just reading the 2017 @ASCO@ASCO_pubs guideline on bone modifying agents for metastatic breast cancer highlights the limits of consensus opinions: No agreement on which of the 3 drugs to use, or whether zoledronic acid should be given every 12 weeks or every 3-4 weeks.
That's kind of strange because denosumab costs 20 times more than the other two. That would have been an easy call for me. But it's listed first.
It looks like two groups could not agree with zoledronic acid should be given every 12 weeks or every 3-4 weeks so they put in both.
I stumbled on this as I'm reviewing a paper today. And it ties into the thread I posted yesterday.
Chronic lymphocytic leukemia. Especially patients on BTK inhibitors (Eg., ibrutinib)nature.com/articles/s4140…
Reduced immune responses in hematologic malignancies. Only half the patients appear to generate sufficient immune protection. Especially if on B cell targeting treatments. #BCJ@BloodCancerJnl@Mohty_EBMTnature.com/articles/s4140…
COVID vaccines are working extremely well in preventing severe disease and deaths. Deaths are much lower relative to cases in post vaccination waves.
Do not miss the forest for the trees.
I didn't make this endpoint about severe disease post hoc. Not changing goalposts. This is how I have always felt. Vaccines will protect especially against severe disease.
The immune response is strengthened and made more durable by each exposure to same antigen. And over time you develop immunity that protects you against severe disease, even if you remain susceptible to mild disease.