Marx literally discusses each and every one of these topics at multiple points in his work, providing excellent insights in every case. Too bad that requires reading to decode, eh?
https://twitter.com/HarrisonKrank/status/1425838851004772354
Differing values of labor is covered in the very beginning of Capital, Ch 1-4, as well as Ch 6, where this quote is from 
Marx discusses human nature extensively, for example in this funny footnote to ch 1 marxists.org/archive/marx/w…
The Grundrisse and the German Ideology also discuss the concept, as does the Theses on Feuerbach
Economies of scale is literally the entire focus of section VII of Capital. Marx uses the term 'accumulation of capital'. Read Ch 23-25 for an excellent discussion. Or watch my lecture summarizing this
It's hard to know what to make of the claim that Marx does not discuss 'supply chains'. Marx is well aware that the supply of raw materials comes from other countries, which he discusses in ch 33 of Capital marxists.org/archive/marx/w…
It is Lenin who more fully develops this point of course, but it is in Marx at many other points, such as Vol 3 of Capital, ch 14 marxists.org/archive/marx/w…
See also "Value, Price, and Profit"
Marx has a great deal to say about the topic of work ethic; it can be found under his many discussions of the concept of alienation. Here is a helpful collection of his writings on the topic marxists.org/subject/aliena…
The basic argument is that the motivation to perform labor has been removed from any human-centered rationale, and has been deeply tainted by the exploitation of capitalism
Marx notes that it's only the working class that is expected to have a 'work ethic'. The rich are free to be indolent haha
The philosophical sophistication of these writings is superb, so there's much more to say about the topic of alienation and work ethic, but suffice it to say it is quite wrong to say Marx failed to consider it when you simply failed to do the reading
The link to Lenin on 'supply chains' (Lenin of course uses the more accurate term 'imperialism') marxists.org/archive/lenin/…
The followers of Marx have deepened the discussion on all these topics substantially btw
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