Thread by @CALonghurst

💥 NEW DATA💥

1/ "Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce" published today in @NEJM details ↓ in vaccine effectiveness against INFECTION among @UCSDHealth employees - from 95%+ in the spring to 65% in July

👉🏽 nejm.org/doi/full/10.10…

2/ Our contact tracing team (led by @DrLucyEHorton) found virutally all known exposures were in the household or community. Few @UCSDHealth employees (mediage age 39) required hospitalization, but each is out 10+ days, creating staffing challenges, as well as additional exposures

3/ Unpublished analysis of cases through 8/26 shows continued ↓ in vaccine effectiveness, with Pfizer at just 49% - one of the reasons that @UCSanDiego has an indoor masking mandate 😷

4/ Analysis by month of vaccination also shows lower effectiveness for those who were fully vaccinated earlier compared to those vaccinated more recently (51% vs. 67%) suggesting waning of immunity and potential benefit of boosters

5/ Based on this data, our team believes that healthcare workers should be offered boosters as soon as possible, particularly as we experience continued record high patient volumes

https://twitter.com/calonghurst/status/1430776706462208001

6/ Many thanks to the entire @UCSDHealth team who helped make this happen, as well as @UofCAHealth @CAPublicHealth @CDCgov colleagues who reviewed data prior to publication