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rubic3n Profile picture
@rubic3n
Sep 4, 2021 • 10 tweets • 5 min read • Read on X
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HYDROXYTYROSOL
(olive leaf extract)

Hydroxytyrosol inhibits Nuclear factor kappa β (NF-κβ) activity - chronic inflammatory diseases

Alleviates peripheral neuropathy
Antidiabetic
Perserves mitochondrial function
BBB!!

sciencedirect.com/science/articl…
HTyr activates neurogenesis in the dentate gyrus
Increasing survival of new neurons and decreasing apoptosis
Multiplication of stem cells
Reduces the markers of aging lipofuscin and Iba1 (as a product of brain aging, reduces their adverse effect)

faseb.onlinelibrary.wiley.com/doi/full/10.10…
HTyr and skin

reducing IL-1α + IL-8 release by RHE tissues
decreased the expression of IL-1β, IL-6, and IL-8 gene

GREATER THAN THE REFERENCE DRUG DEXAMETHASONE .

MMP-1 and MMP-3 by UVA were decreased dose-dependent
excellent transcutaneous absorption

link.springer.com/article/10.100…
HTyr effect on skin aging
onlinelibrary.wiley.com/doi/10.1111/ic…
biomeddermatol.biomedcentral.com/articles/10.11…
HTyr
Taking the bullet out of the gun

- inhibited prostaglandin (PG)E2 production and COX-2 expression, without affecting COX-1 and activity in human activated monocytes
mediated by
- down-regulation of phorbol ester-induced NF-κB activation
- reduces PKCα and PKCβ1 activation
atherosclerosis-journal.com/article/S0021-…
Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health
Good Overview

HTyr can cross the BBB!

europepmc.org/article/MED/31…
HTyr
Promotes Proliferation of Human Schwann Cells (in vitro)

"HT stimulates the proliferation of hSCs in vitro, indicated by a significant increase in the hSC proliferation index and protein expression of hSCs' proliferation markers, p75 NGFR and GFAP"

europepmc.org/article/MED/32…
"Natural Polyphenols and Spinal Cord Injury SCI"
Also post injury care
Overview

ncbi.nlm.nih.gov/pmc/articles/P…
"Natural polyphenols effects on protein aggregates in Alzheimer's and Parkinson's prion-like diseases"
Main effects of cited polyphenols modulating protein aggregates
In vitro (A) and in vivo (B)

(A) nrronline.org/article.asp?is…

(B) researchoutput.csu.edu.au/ws/portalfiles…

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More from @rubic3n

rubic3n Profile picture
Aug 8
@robinmonotti Chitosan, an early off spring from Industry4.0 research into a replacement for crude oil based polymeres.
Enormous amounts of Chitosan are needed.
Just one area of use:
@robinmonotti
More data points?
@robinmonotti
Removal of stains
You need to eat the bugs, to not waste all the chitin carcasses produced while creating highly desirable insect polymers
Read 8 tweets
rubic3n Profile picture
Nov 6, 2023
Vaccines - whereever we look.

Had you realized that there was a major project milestone in the 'Immunization Agenda 2030'? That there was such an agenda at all?
GVAP, the Global Vaccine Action Plan

They call their strategic elements PAPRIKA and SAGE. haha
@Fynnderella1

Image
Image
Image
Random 'high-lights':
- Accept climate change as disease driver
- Everyone behind the vax move
- All leaders in the global vax push

Nice bullet points in pink.

iris.who.int/bitstream/hand…



Image
Image
Image
Image




A 'truly bottom up approach' look alike

European Union
GAVI
UNICEF
other UN organization
US Centers for Disease Control and Prevention

Bottom up. bundesgesundheitsministerium.de/fileadmin/Date…
iris.who.int/bitstream/hand…
Image
Read 6 tweets
rubic3n Profile picture
Jan 29, 2023
Even if insect larvae and adult insects should be appropriate for human or even animal consumption, the question still remains, under which 'fraudulent' conditions they are bred and which - if any- effective control over production can be exerted. With gross effect on ingredients
Article in Proteinmarkt
archive.ph/FrV1D
"A number of unknowns []
difficult to obtain data"

from the project
'Sustainable Transitions' University Hannover (link in next tweet)
Sustainable Transistions Project
archive.ph/v2dsi
archive.ph/h2pri
archive.ph/MKy6u
Read 10 tweets
rubic3n Profile picture
Jul 2, 2022
Malva Silvestris

Throat and gut, to treat inflammatory diseases of mucous membranes, cystitis, and diarrhea

Nutritional Compounds for Metabolites, Antioxidants, and Anti-Inflammatory, Anticancer, and Antimicrobial Hepatoprotective
ncbi.nlm.nih.gov/pmc/articles/P…
Seems familiar?
Controlling eicosanoid products, including the pro-inflammatory mediator prostaglandin and a variety of cytokine targets like IL-1β IL-6, IL-8 and granulocyte-macrophage colony-stimulating factor GM-CSF.
Malvidin 3-glucoside, scopoletin and quercetin
ncbi.nlm.nih.gov/pmc/articles/P…
Rutin could inhibit more than 20 genes coding for critical pro-inflammatory factors including TNF-α, IL-1β, IL-1 and IL-8, and migration inhibitory factor
"[IVM, Colchicine to block IL-1b] If you block IL-1B, then you block the amyloid response that the fibrosis of the myocardia"
Read 6 tweets
rubic3n Profile picture
May 29, 2022
Dr. Mark Buller
US's leading Orthopox Virus
At least two rounds of gain of function research on viruses related to smallpox.

t.me/JesseMatchey/6…
#amazingpolly #vaccines #gainoffunction
NYT Mousepox Gain of Function: nytimes.com/2003/11/01/us/…

Buller Says Vaccine for Monkeypox (using smallpox vax) NOT recommended: pubmed.ncbi.nlm.nih.gov/17661673

Buller paper on Monkeypox Outbreaks up to 2012: pubmed.ncbi.nlm.nih.gov/23626656/
Judicial Watch re James Leduc / Wuhan: judicialwatch.org/wuhan-lab-fauc…

National Biocontainment Training Center report by Leduc: apps.dtic.mil/sti/pdfs/AD102…
Read 9 tweets
rubic3n Profile picture
Dec 24, 2021
80% of diseases not treatable with 'conventional medicine'. Protein treatment as an alternative with drawbacks.
An 80% market for mRNA. Yet, the vector is the bottleneck causing the limitation.
Viral V is almost a 'use once only' bcs of antibody formation.
LNP sole way to push.
mRNA Therapy - with a gargantuan market - in dire need for a vector.
Viral vectors as a dead ally until 2015.
mRNA Therapy meets enormous resentments.

Luckily, billions of people have now got first hand experience. Obviously, AZ was not that useful in the general drift. Image
LNP instead of a vector
PFIZER BioNtech

ALC-0315
ALC-0159, DSPC
"This product is for research use only and not for human use."


'EMA Zulassung ohne Daten'
Read 26 tweets

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