Thread by @MisterRan

SARS-CoV-2 mRNA Vaccination-Associated Myocarditis in Children Ages 12-17: A Stratified National Database Analysis.

Main outcome measures
1) Stratified rates of mRNA vaccine-related myocarditis in adolescents age 12-15 and 16-17;

medrxiv.org/content/10.110…

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2) harm-benefit analysis of vaccine-related CAEs in relation to COVID-19 hospitalization risk.

Conclusions Post-vaccination CAE rate was highest in young boys aged 12-15 following dose two. For boys 12-17 without medical comorbidities,

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the likelihood of post vaccination dose two CAE is 162.2 and 94.0/million respectively. This incidence exceeds their expected 120-day COVID-19 hospitalization rate at both moderate (August 21, 2021 rates) and high COVID-19 hospitalization incidence.

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Further research into the severity and long-term sequelae of post-vaccination CAE is warranted. Quantification of the benefits of the second vaccination dose and vaccination in addition to natural immunity in this demographic may be indicated to minimize harm.

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Cardiac Adverse Event (CAE) rates per million adolescents following vaccination doses 1 and 2, by age and sex.

Total number of Cardiac Adverse Event (CAE) hospitalizations by age and sex

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Median of Peak Troponin by age and sex in ng/mL

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Symptom onset interval of Cardiac Adverse Events in days following vaccination among recipients with elevated troponin, by age

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Vaccine recipients with cardiac adverse events by vaccination dose UNK= unknown

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Harm-benefit analysis for second dose of mRNA vaccine vs. COVID-19 hospitalization for boys ages 12-17 in the context of disease incidence and presence of ≥1 comorbidity.
Darker shading denotes vaccine-associated risk of myocarditis equivalent to or exceeds disease-

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associated hospitalizations.

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Harm-benefit analysis for second dose of mRNA vaccine cardiac adverse event (CAE) in boys by age vs. COVID-19 hospitalization risk in the context of disease prevalence and presence of ≥1 comorbidity.

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CDC working case definition for acute myocarditis

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Pediatric COVID-19 hospitalization rates by age and week in the United States from COVID-NET [8].