This NEJM booster paper DOES NOT justify mass population boosting
4 issues
1. People who get boosters and those who do not are TOTALLY different people. Look at table 1.
This is confounding by indication/ diff. people/ diff behavior
4 issues
1. People who get boosters and those who do not are TOTALLY different people. Look at table 1.
This is confounding by indication/ diff. people/ diff behavior
2. The effect size for severe disease is RR 20!
Too good to be true.
An RCT will be fast to exclude a benefit of this size (its just resid. confounding)
Too good to be true.
An RCT will be fast to exclude a benefit of this size (its just resid. confounding)
3. The benefit on any disease is smaller than on severe disease, which makes less sense from an Ab point of view (should be opposite), and more from the type of people getting booster point of view.
4. THIS PAPER CANNOT JUSTIFY MASS POPULATION VACCINATION
5, Bonus: if you want to vaccine 100 million people, we need an RCT powered for severe disease, which will provide clarity on AEs.
We can't let anxiety drive this policy.
We can't let anxiety drive this policy.
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