Thread by @MisterRan

FDA:
we have concluded there is an increased risk of serious heart-related events such as heart attack or stroke, cancer, blood clots, and death with the arthritis and ulcerative colitis medicines Xeljanz and Xeljanz XR (tofacitinib).

Do you know who manufactures this drug ?

2)
The pharmaceutical company called Pfizer.

fda.gov/drugs/drug-saf…

And the FDA is not alone .

EMA:

Xeljanz (tofacitinib): increased risk of major adverse cardiovascular events and malignancies with use of tofacitinib relative to TNF-alpha inhibitors

ema.europa.eu/en/documents/d…

4)
I will try to explain more about this drug and more importantly, how many years it took from the step 1 of the development until the drug was approved.
And why is it So important especially this days ?
You will see

5)

A Brief History of Tofacitinib:

In the summer of 1993, Dr. Paul Changelian, a scientist in Pfizer’s immune suppression group, was looking for a new way to prevent organ transplant rejection. 

Watch carefully: 1993

forbes.com/sites/johnlama…

6)

The immunology team worked diligently on this and by 2000, seven years after initiating the program, a JAK inhibitor, CP-690,550 (later to be christened tofacitinib)

Again , 7 years only to discuss .

Year 2000

Clinical trials:
From 2000 to 2011,
Including pre clinical,

Before going to humans, tofacitinib was studied at Stanford University in a rigorous monkey model for kidney transplantation.

In 2011, 11 years after clinical trials as started,

Pfizer Announces FDA Acceptance for Review of New Drug Application for Tofacitinib for Adult Patients with Moderately to Severely Active Rheumatoid Arthritis.

In November 6, 2012 ,

The U.S. Food and Drug Administration today approved Xeljanz (tofacitinib) to treat adults with moderately to severely active rheumatoid arthritis

drugs.com/history/xeljan…

In December 14, 2017 , Pfizer Announces FDA Approval of Xeljanz (tofacitinib) and Xeljanz XR for the Treatment of Active Psoriatic Arthritis

drugs.com/newdrugs/pfize…

In May 30, 2018,

Pfizer Announces U.S. FDA Approves Xeljanz (tofacitinib) for the Treatment of Moderately to Severely Active Ulcerative Colitis.

drugs.com/newdrugs/pfize…

In September 28, 2020 ,

U.S. FDA Approves Pfizer’s Xeljanz (tofacitinib) for the Treatment of Active Polyarticular Course Juvenile Idiopathic Arthritis

drugs.com/newdrugs/u-s-f…

And in 01/09/2021, almost 9 years from the approval , The FDA warns about this drug .
Drug that can cause serious heart-related events, cancer, blood clots, and death .

fda.gov/drugs/drug-saf…

So ,as you see, it is taking so many years to develop new drug.
this drug , it took almost 19 years from the first step, until it was approved.
So how the hell FDA approved the so called Corona vaccine after 2 months of trials, even without pre clinical trials?
Only god knows

And even after so many years of trials and using this drug , it is proven to be unsafe medicine, that kills patients.