Thread by @MonicaGandhi9

JOHNSON & JOHNSON TWO DOSE DATA TODAY: First, want to remind us how J&J vaccine works. More "traditional vaccines" are proteins of the vaccine combined with an adjuvant (see thread on Novavax). J&J and mRNA vaccines novel in that they put genetic material of the spike protein

into a lipid container (mRNA vaccines) or into a benign cold virus (DNA inside an adenovirus vector with J&J) and then YOU as the host take that genetic material and code it into the spike protein to which you raise immune response (mRNA or DNA & spike protein degrade right away)

So, what did J&J press release show today? That even ONE dose conferred long-lasting protection against hospitalizations/death (81% protection against hospitalizations median 4 months in study) and that is because of yes, cellular immunity. Effectiveness
jnj.com/johnson-johnso…

against any infection 79% even with circulation of delta in the US. Booster at 2 months (56 days) - did not report what % increased protection against any infection (symptomatic or asymptomatic); said 100% protection against hospitalization but that is only data at 14 days after

2nd dose. 94% protection against symptomatic infection in US (75% elsewhere). Bottom line? Think vaccine principles. We have circulating virus in US > other places due to low vax, so 2nd dose for J&J seems prudent. Only yellow fever vax is a 1 dose for life & even there we say

get another shot if travel to high incidence region with high risk exposure so between data from CDC MMWR last Fri of J&J lower protection against hospitalization in current time, would give 2nd shot of J&J. Still think cellular memory from J&J 1-shot good

https://twitter.com/MonicaGandhi9/status/1438873395144249347?ref_src=twsrc%5Etfw