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Céline Gounder, MD, ScM, FIDSA Profile picture
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27 Sep, 5 tweets, 2 min read
1/ How do we convince the unvaccinated to get vaccinated?

Emphasize the CONCRETE & SHORT-TERM costs of getting COVID, esp missing out on things they love doing or care about.

Hospitalization & death might seem abstract & unlikely.

nytimes.com/2021/09/27/bri…
(h/t @DLeonhardt)
2/ Emphasize DUTY to family, neighbors, workplace, & community.

If you're sick and can't fulfill your obligations, who does that fall back on?

washingtonexaminer.com/opinion/risk-a…
3/ Have one-on-one conversations.

Start with what people care about & what impact the pandemic has had on them, their families, work, & school.

LISTEN

DON'T SHAME OR BLAME

justhumanproductions.org/podcasts/s1e73…
4/ Encourage them to talk to their doctors.

25% of Americans don't have primary care doctors.

But for the other 75% who do, their personal doctors are a trusted source of information.

justhumanproductions.org/podcasts/s1e70…
5/ Get older conservatives to reach out to younger conservatives.

Older conservatives are more likely to remember kids paralyzed from polio and may be more likely to have had or know someone who's had a serious bout of COVID than younger conservatives.

theatlantic.com/politics/archi…

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More from @celinegounder

Céline Gounder, MD, ScM, FIDSA Profile picture
28 Sep
1/ What do we know about mixing & matching COVID vaccines (aka heterologous prime-boost)?

Clinical trial data coming out soon.

c-span.org/video/?c497926…
2/ @NIH @NIAIDNews
Phase I/II clinical trial of boosting 12+ weeks
after 2 Moderna, 2 Pfizer, or 1 J&J
- To assess safety & reactogenicity
- To assess the breadth of humoral immune responses
clinicaltrials.gov/ct2/show/NCT04…
3/ They're studying all possible combinations:

1 J&J➡️1 Moderna
1 J&J➡️1 J&J
1 J&J➡️1 Pfizer
2 Moderna➡️1 Moderna
2 Moderna➡️1 J&J
2 Moderna➡️1 Pfizer
2 Pfizer➡️1 Moderna
2 Pfizer➡️1 J&J
2 Pfizer➡️1 Pfizer

With follow-up 14d, 28d, 3m, 6m, 12m after the booster dose.
Read 4 tweets
Céline Gounder, MD, ScM, FIDSA Profile picture
28 Sep
1/ Merck/Ridgeback, Pfizer, & Roche/Atea all have oral antiviral pills for the treatment of COVID in phase II/III clinical trials.

We anticipate results in the next couple of months with submission to the @US_FDA to follow soon thereafter.

But will these be game-changing?
2/ Remdesivir & monoclonal antibodies, both therapeutics for COVID, haven't been game-changing.

It's BEST to prevent COVID with VACCINATION.

But it's good to have COVID therapeutics as a backup measure, especially for older & more vulnerable or immunocompromised people.
3/ COVID drugs work by blocking the machinery that allows the virus to replicate. This reduces the viral load and the duration of infection. But if the damage has already been done, COVID drugs won't reverse that.
Read 5 tweets
Céline Gounder, MD, ScM, FIDSA Profile picture
28 Sep
1/ Pfizer submitted COVID vaccine data for kids 5-11 to the @US_FDA today. Kids in this age group could be eligible for vaccination by late October.

But what % of these kids will get vaccinated?

nytimes.com/2021/09/28/us/…
2/ What do we know based on kids 12-17?

As of mid-August,
41% already vaccinated
6% were getting vaccinated right away

kff.org/coronavirus-co…
3/ #1 predictor of kids 12-17 getting vaccinated?
Parents' vaccination status

Also predictors:
Older parents
Democratic parents
Higher-income parents
More educated parents
Read 6 tweets
Céline Gounder, MD, ScM, FIDSA Profile picture
28 Sep
1/ @KFF September vaccine monitor survey:
- FEAR is a powerful motivator. Delta surge has been the PRIMARY MOTIVATOR for recently vaccinated.
- FDA approval & mandates have also played a role.

kff.org/coronavirus-co…
2/
 - Biggest increases in vaccine uptake among Hispanic adults & young adults 18-29.
- Similar % of adults vaccinated by race/ethnicity:
- White 71%
- Black 70%
- Hispanic 73%
- Gaps remain by partisanship, education level, age, health insurance status
3/ “When a theoretical threat becomes a clear and present danger, people are more likely to act to protect themselves and their loved ones,” said @DrewAltman, the @KFF's chief executive.

nytimes.com/2021/09/28/hea…
Read 4 tweets
Céline Gounder, MD, ScM, FIDSA Profile picture
26 Sep
1/ When will we finally understand that WE'RE ALL IN THIS TOGETHER, in the US & around the world.

The Delta variant is proof that what happens halfway around the world can threaten us all.

Vaccinating the rest of the world is in our SELF-INTEREST.

nytimes.com/2021/09/25/opi… Image
2/ So we were worried about running out of COVID vaccine for ourselves, hoarded that supply, & then retrofit arguments to justify our actions?

politico.com/news/2021/09/2… Image
3/ politico.com/news/2021/09/2… Image
Read 8 tweets
Céline Gounder, MD, ScM, FIDSA Profile picture
24 Sep
1/ Overnight, @CDCDirector overrode the @CDCgov's ACIP recommendations on vaccinating workers in high-risk occupations.

politico.com/news/2021/09/2…

It's important that we be clear WHY.
2/ Are we giving boosters to people in high-risk occupations:
- To protect them because they're at high risk for severe disease?
OR
- For the safety of the workplace & to keep them on the job?
3/ There isn't good data to support giving boosters to people in high-risk occupations to protect THEM from severe disease.
Read 8 tweets

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