#SaferThanSmoking - A Thread...
#SaferThanSmoking #SNEWS
“Use of snus confers a significant harm reduction benefit [vs smoking] which is reflected in the comparatively low levels of tobacco-related disease in Sweden compared with the rest of Europe [where snus is illegal].”
harmreductionjournal.biomedcentral.com/articles/10.11…
#SaferThanSmoking #SNEWS
“The IQOS heated tobacco product emits substantially lower levels of carbonyls than a commercial tobacco cigarette but higher levels than an e-cigarette.”
pubmed.ncbi.nlm.nih.gov/29920842/
#SaferThanSmoking #SNEWS
“Our results clearly show a lower toxicity of e-liquids, including flavoured e-liquids, when compared to cigarette smoke condensate.”
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
“Aldehyde emissions from all flavoured liquids were 79–99.8% lower than smoking and lower than commonly measured indoor levels and occupational and indoor safety limits.”
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
“...flavors were added to the tobacco rod and the resultant smoke was analyzed for priority smoke constituents ... addition of the flavors had no effect on, or reduced the levels of most of the measured smoke constituents.”
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
“Overall, ECig vapour extracts showed significantly higher cell viability compared to Cigarette Smoke extract, based on a realistic-use rather than a standardized comparative level of exposure.”
mdpi.com/1660-4601/10/1…
#SaferThanSmoking #SNEWS
“Use of an ENDS with cigarette-like nicotine delivery can reduce exposure to a major pulmonary carcinogen, NNAL, even with concurrent smoking.”
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
“Our study indicated that the cytotoxicity of e-cigarette was far less than conventional cigarette at equivalent nicotine content in BEAS-2B cells.”
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
“Even if they should not be considered as risk-free products, Heated Tobacco Products and E-cigarettes lead to an appreciable risk reduction in comparison to cigarettes, both for cancer and non-cancer diseases.”
link.springer.com/article/10.100…
#SaferThanSmoking #SNEWS
“Among established, every day, exclusive tobacco product users, the geometric mean urinary NNAL concentration was highest for smokeless tobacco users, followed by combustible tobacco users, and e-cigarette users.”
academic.oup.com/ntr/article/23…
#SaferThanSmoking #SNEWS
This RCT found that nicotine salt pod systems for replacing cigarettes led to significant reduction in a primary pulmonary carcinogen, NNAL...1/4 of ecig participants were able to fully cease use of combustible cigs at week 6
jamanetwork.com/journals/jaman…
#SaferThanSmoking #SNEWS
“In accordance with the levels of toxic compounds in each aerosol, Heated Tobacco Product aerosol exhibits reduced cytotoxicity compared to cigarette smoke but higher than e-cig vapours.”
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
“The results of this study concorded with evidence that complete switching from combustible cigarettes to vapor products may reduce exposure to carcinogens and toxicants known to be associated with tobacco-related diseases.”
academic.oup.com/ntr/article/22…
#SaferThanSmoking #SNEWS
“E-cigarette use was associated with significant decreases in exposure to nicotine and other chemicals such as benzene and acrolein, typically found in combustible cigarette smoke.”
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
“Results from this study suggest that e‐cigarettes may have reduced tumor promoter activity compared to conventional cigarettes and therefore may provide a safer alternative to cigarettes.”
ncbi.nlm.nih.gov/pmc/articles/P…
#SaferThanSmoking #SNEWS
“Samples of a prototype heat-not-burn device have lower cancer potencies than tobacco smoke by at least one order of magnitude, but higher potencies than most e-cigarettes.”
tobaccocontrol.bmj.com/content/27/1/10
#SaferThanSmoking #SNEWS
“Long-term NRT-only and e-cigarette–only use...is associated with substantially reduced levels of measured carcinogens and toxins relative to smoking only combustible cigarettes.”
acpjournals.org/doi/10.7326/M1…
#SaferThanSmoking #SNEWS
Comparisons of pollutants were made between e-cig vapor and tobacco smoke. Non-cancer risk analysis revealed no significant risk of harm to humans for samples from e-liquids. Cancer risks for e-liquids didn’t exceed the risk limit
tandfonline.com/doi/abs/10.310…
#SaferThanSmoking #SNEWS
“Most e-cigarettes had cancer potencies that were less than 1 percent of cigarette smoke, although a small minority had much higher potency than the others.”
lungdiseasenews.com/2017/08/25/stu…
#SaferThanSmoking #SNEWS
“Most e-cigarette analyses indicate cancer potencies <1% that of tobacco smoke and <10% that of a heat-not-burn prototype.”
tobaccocontrol.bmj.com/content/27/1/10
#SaferThanSmoking #SNEWS
“E-cigarette extracts did not inhibit migration, allowing cells to migrate into the wounded area. Our data demonstrate that e-cigarettes do not induce the inhibition of endothelial cell migration in vitro when compared to 3R4F.”
pubmed.ncbi.nlm.nih.gov/28658606/
#SaferThanSmoking #SNEWS
“Compared with cigarettes, G2 and G3 e-cigarettes resulted in significantly lower levels of exposure to a potent lung carcinogen and cardiovascular toxicant.”
tobaccocontrol.bmj.com/content/26/e1/…
#SaferThanSmoking #SNEWS
After switching from tobacco to e-cigarettes, nicotine exposure remains unchanged, while exposure to selected carcinogens and toxicants is substantially reduced.
academic.oup.com/ntr/article-ab…
#SaferThanSmoking #SNEWS
...e-cigarette ACM and aerosol were deemed non-mutagenic in tester strains TA98 and TA100... Conversely, 3R4F cigarette smoke TPM and freshly generated whole smoke were clearly positive.
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
Based on current knowledge, for patients with lung or other forms of cancer who would otherwise continue to smoke, e-cigarettes offer an alternative way to quit smoking while they undergo medical treatment.
lungcancerjournal.info/article/S0169-…
#SaferThanSmoking #SNEWS
Despite being tested with a more intense puffing regime, e-cigarette aerosol showed no acute cytotoxicity in this study when compared with traditional 3R4F reference cigarette smoke.
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
Under the study conditions cigarette smoke demonstrated a dose-dependent response that resulted in near-complete cell death after 6h exposure. In contrast, e-cig aerosol showed no decrease in tissue viability following 6h exposure
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
The levels in e-cig vapor is from 9 to 450-fold lower than those in the smoke from conventional cigarettes, and in many cases comparable to the trace amounts present in pharmaceutical nicotine inhaler
ncbi.nlm.nih.gov/pmc/articles/P…
#SaferThanSmoking #SNEWS
With respect to the compounds analyzed here, e-cigarettes have a more favorable toxicity profile than tobacco cigarettes.
ncbi.nlm.nih.gov/pmc/articles/P…
#SaferThanSmoking #SNEWS
There is no reliable evidence that e-cigarette use is associated with ever having had a myocardial infarction among never smokers.
ajpmonline.org/article/S0749-…
#SaferThanSmoking #SNEWS
Exclusive e-cigarette users have biomarker concentrations that are similar to those of former smokers who do not currently use tobacco, and lower than those of exclusive cigarette smokers.
cebp.aacrjournals.org/content/early/…
#SaferThanSmoking #SNEWS
Tobacco cigarettes, not e-cigarettes, are associated with increased expression of major proteins in the toll-like receptor 4 (TLR4) inflammasome-interleukin (IL)-6 signalling axis in monocyte subtypes and T cells.
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
These findings implicate the non-nicotine, pro-oxidant toxicants in tobacco cigarette smoke as instigators of increased expression of key proteins in the TLR4-inflammasome-IL-6 axis that contribute to atherogenesis, [not e-cigs]
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
TCIGs but not ECIGs are associated with increased expression of key proteins in the TLR4–inflammasome–IL‐6 signaling axis, ...ECIGs may represent a harm reduction approach to those addicted to TCIGs who are unable to quit.
ahajournals.org/doi/10.1161/JA…
#SaferThanSmoking #SNEWS
Electronic cigarette vaping improves arterial elastic properties and oxidative stress after 4mths of use. Tobacco cigarette smoking causes further impairment of arterial elasticity and oxidative stress during 4mths of use
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
Endothelial dysfunction, as measured by flow mediated vasodilation(FMD) is a predictor of future atherosclerosis and adverse cardiovascular events, and is impaired in tobacco cigarette (TC) smokers.
journals.physiology.org/doi/abs/10.115…
#SaferThanSmoking #SNEWS
FMD was significantly impaired after smoking one TC, but not after vaping an equivalent "dose" of an e-cigarette, consistent with the notion that non-nicotine constituents in TC smoke mediate the impairment.
journals.physiology.org/doi/abs/10.115…
#SaferThanSmoking #SNEWS
Blood lead levels, and urinary cadmium, barium, and antimony levels were similar between participants who ever-used e-cigarettes and participants who did not, and therefore, e-cigarette use was not a major source of heavy metals.
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
Tobacco Cigarette smokers, particularly females, demonstrate significant improvement in vascular health within 1 month of switching from TC to E-Cigarettes
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
...it seems likely that on the spectrum of tobacco products, ECs are less harmful than TCs, and there is increasing evidence that ECs may help promote TC cessation.
dovepress.com/electronic-cig…
#SaferThanSmoking #SNEWS
E-cig...causes a smaller increase of arterial stiffness and oxidative stress, compared to a single normal cigarette... Replacement of normal cigs by...EC results in improved aortic elasticity and oxidative stress within 1 month.
academic.oup.com/eurheartj/arti…
#SaferThanSmoking #SNEWS
Human coronary artery endothelial cells show a biological response to cigarette smoke.
This response was not seen following exposure to e-cigarette aerosol.
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
Electronic cigarettes deliver nicotine without combustion of tobacco and appear to pose low-cardiovascular risk, at least with short-term use, in healthy users.
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
Smoking cessation with the use of electronic cigarette led to reversal of chronic idiopathic neutrophilia. The daily use of electronic cigarette may help preserve the beneficial effects of smoking cessation.
ncbi.nlm.nih.gov/pmc/articles/P…
#SaferThanSmoking #SNEWS
Tobacco cigarettes increased white blood cell, lymphocyte, granulocyte counts, and secondary proteins of acute inflammatory load for at least one hour, using e-cigarettes did not show these increases in smokers and never smokers.
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
Heart rate increased from an avg of 65.7 at baseline to a peak of 80.3 5 minutes after the first administration under the tobacco cigarette condition. No significant changes in heart rate were observed for the e-cig.
#SaferNicotine
ncbi.nlm.nih.gov/pmc/articles/P…
#SaferThanSmoking #SNEWS
Several self-reported and randomized studies suggest that e‑cigarettes are a harm-reduction strategy that may improve the oral and general health of smokers and may contribute to smoking cessation.
jcda.ca/k7
#SaferThanSmoking #SNEWS
A potential implication of these results is that flavorless E-liquids and their generated aerosol induce less tooth decay and periodontal disease than traditional cigarette smoke.
ncbi.nlm.nih.gov/pmc/articles/P…
#SaferThanSmoking #SNEWS
A case for improving oral health (and overall health) could be made by federal health regulatory agencies for promoting the use of electronic nicotine delivery systems over the use of traditional cigs as a means of harm reduction.
ncbi.nlm.nih.gov/pmc/articles/P…
#SaferThanSmoking #SNEWS
Periodontal inflammatory parameters are worse in cigarette-smokers than individuals vaping electronic cigarettes and never-smokers following FMUS (full-mouth ultrasonic scaling).
pubmed.ncbi.nlm.nih.gov/30361795
#SaferThanSmoking #SNEWS
Our results suggest reduced toxicant exposure, reduced oxidative stress, and potential beneficial changes in vitamin metabolism within 5 days in smokers switching to Vuse ENDS.
pubmed.ncbi.nlm.nih.gov/33165576
#SaferThanSmoking #SNEWS
...e-cigarettes still hold a great potential to reduce incidences of tobacco-related diseases and could be a part of the strategy to reduce the damage caused by smoking.
mp.pl/paim/issue/art…
#SaferThanSmoking #SNEWS
...for e-cigarettes the particle concentration returned rapidly to background values within seconds; for conventional cigarettes it increased with successive puffs, returning to background levels after 30–45 minutes.
academic.oup.com/ntr/article/21…
#SaferThanSmoking #SNEWS
Our projections show that a strategy of replacing cigarette smoking with vaping would yield substantial life year gains, even under pessimistic assumptions regarding cessation, initiation and relative harm.
tobaccocontrol.bmj.com/content/27/1/18
#SaferThanSmoking #SNEWS
In conclusion, cigarette smoke preparations, but not ENDS preparations, adversely alter lung physiology and elicit features associated with COPD and lung cancer.
pubmed.ncbi.nlm.nih.gov/33207918/
#SaferThanSmoking #SNEWS
Our data add to the efficacy and safety of e-cigarettes in helping smokers reducing tobacco consumption and improving pulmonary health status.
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
Findings suggest that differences in respiratory symptoms between dual and exclusive e-cigarette users appear to be attributable to combustible cigarette smoking, rather than... e-cigarette use .
academic.oup.com/ntr/article/22…
Smokers who switched to exclusive use of combustion-free nicotine delivery systems exhibit similar saccharin transit time as never smokers. This suggests that combustion-free delivery technologies are unlikely to have detrimental effects on MCC function
medrxiv.org/content/10.110…
#SaferThanSmoking #SNEWS
The present study suggests that EC use may ameliorate objective and subjective COPD outcomes, and that the benefits gained appear to persist long term.
journals.sagepub.com/doi/full/10.11…
#SaferThanSmoking #SNEWS
Furthermore, switching from tobacco smoking to e-cigs showed a significant improvement in asthma control and quality of life, not showing, in the period studied, to affect pulmonary function tests.
pubmed.ncbi.nlm.nih.gov/31960343
#SaferThanSmoking #SNEWS
...we are now confident that current vaping products are much less harmful than conventional cigarettes.
tandfonline.com/doi/full/10.10…
#SaferThanSmoking #SNEWS
The present study suggests that EC use may ameliorate objective and subjective COPD outcomes and that the benefits gained may persist long-term. EC use may reverse some of the harm resulting from tobacco smoking in COPD patients.
dovepress.com/health-effects…
#SaferThanSmoking #SNEWS
ECs... are less harmful than conventional tobacco smoking. The emerging clinical evidence suggests that ECs are unlikely to raise health concerns for the respiratory tract..., even in smokers with preexisting lung disease.
dovepress.com/e-cigarettes-i…
#SaferThanSmoking #SNEWS
Based on equivalent or higher nicotine delivery, an acute exposure to e-cigarette aerosol had a reduced impact on gene expression compared to 3R4F smoke exposure in vitro.
ncbi.nlm.nih.gov/pmc/articles/P…
#SaferThanSmoking #SNEWS
The surfactant inhibitory compound in conventional cigarettes is tar, which is a product of burning and is thus absent in e-cigarette vapor.
respiratory-research.biomedcentral.com/articles/10.11…
#SaferThanSmoking #SNEWS
These findings suggest that ECs may aid smokers with COPD reduce their cigarette consumption or remain abstinent, which results in marked improvements in annual exacerbation rate as well as subjective and objective COPD outcomes.
ncbi.nlm.nih.gov/pmc/articles/P…
#SaferThanSmoking #SNEWS
941 smokers who switched to e-cigarettes. Overall, 29% of responders reported no change in respiratory symptoms, 5% reported worsening, and 66% reported an improvement.
omicsonline.org/open-access/ch…
#SaferThanSmoking #SNEWS
Smokers invited to switch to electronic cigarettes, who completely abstained from smoking, showed steady progressive improvements in their exhaled breath measurements and symptom scores.
onlinelibrary.wiley.com/doi/abs/10.111…
#SaferThanSmoking #SNEWS
Also, given that the propylene glycol in EC aerosols is a potent bactericidal agent, switching from smoking to regular vaping is likely to produce additional lung health benefits.
pneumonia.biomedcentral.com/articles/10.11…
#SaferThanSmoking #SNEWS
Smokers who quit by switching to EC use can reduce risk and reverse harm from tobacco smoking. Innovation in the e-vapour category is likely not only to further minimise residual health risks, but also to maximise health benefits.
pneumonia.biomedcentral.com/articles/10.11…
#SaferThanSmoking #SNEWS
This prospective study confirms that EC use ameliorates objective and subjective asthma outcomes in asthmatic smokers who switch and shows that these beneficial effects may persist in the long term.
pubmed.ncbi.nlm.nih.gov/27011045/
#SaferThanSmoking #SNEWS
EC use can reverse harm from smoking in asthma patients who smoke. The notion that substitution of conventional cigs with EC is unlikely to raise significant respiratory concerns, can improve counseling with asthmatic patients.
pubmed.ncbi.nlm.nih.gov/27011045/
#SaferThanSmoking #SNEWS
The e-cig may help smokers with asthma to reduce their cigarette consumption or remain abstinent and hence reduce the burden of smoking-related asthma symptoms.
ncbi.nlm.nih.gov/pmc/articles/P…
#SaferThanSmoking #SNEWS
The positive findings observed with e-cigs allows us to advance the hypothesis that these products may be valuable for smoking cessation and tobacco harm reduction also in asthma patients who smoke.
ncbi.nlm.nih.gov/pmc/articles/P…
#SaferThanSmoking #SNEWS
...E-cigs may not only improve asthma symptoms and pulmonary function but may also confer an overall health advantage in smokers with asthma.
ncbi.nlm.nih.gov/pmc/articles/P…
#SaferThanSmoking #SNEWS
Therefore, e-cig use in asthmatic smokers unable or unwilling to quit should be exploited as a safer alternative for harm-reversal (asthma-related) and for harm-reduction (smoke-related diseases).
ncbi.nlm.nih.gov/pmc/articles/P…
#SaferThanSmoking #SNEWS
All tests showed reduced cell viability following 1R6F smoke exposure and slight or no reduction with ENDS at 24 hours.
pubmed.ncbi.nlm.nih.gov/34314750/
#SaferThanSmoking #SNEWS
Blood lead levels, and urinary cadmium, barium, and antimony levels were similar between participants who ever-used e-cigarettes and participants who did not. E-cigarette use was not a major source of heavy metals.
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
There is conclusive evidence that completely substituting e-cigarettes for combustible cigarettes reduces users’ exposure to numerous toxicants and carcinogens present in tobacco cigarettes.
nap.edu/read/24952/cha…
#SaferThanSmoking #SNEWS
There is substantial evidence that except for nicotine, under typical conditions of use, exposure to potentially toxic substances from e-cigarettes is significantly lower compared with combustible tobacco cigarettes.
nap.edu/read/24952/cha…
#SaferThanSmoking #SNEWS
There is substantial evidence that completely switching from regular use of combustible tobacco cigarettes to e-cigarettes results in reduced short-term adverse health outcomes in several organ systems.
nap.edu/read/24952/cha…
#SaferThanSmoking #SNEWS
There is moderate evidence that risk and severity of dependence are lower for e-cigarettes than combustible tobacco cigarettes.
nap.edu/read/24952/cha…
#SaferThanSmoking #SNEWS
...exclusive e-cigarette users had lower concentrations of biomarkers of nicotine, tobacco-specific nitrosamines, VOCs, and metals than those observed in current exclusive cigarette smokers.
ncbi.nlm.nih.gov/pmc/articles/P…
Concentrations of most trace metals (except Ni) from cig smoke exceed the concentrations of trace metals from ECIG aerosol. It is unlikely that the ECIG-generated aerosol contains enough of the other trace metals to induce significant pathology.
frontiersin.org/articles/10.33… #SNEWS
#SaferThanSmoking #SNEWS
The risks from benzene will be lower from e-cigarettes than from conventional cigarettes.
ncbi.nlm.nih.gov/pmc/articles/P…
#SaferThanSmoking #SNEWS
The hazard to health arising from long-term vapour inhalation from the e-cigarettes available today is unlikely to exceed 5% of the harm from smoking tobacco.
rcplondon.ac.uk/projects/outpu…
#SaferThanSmoking #SNEWS
EVP use was associated with significant decreases in exposure to nicotine and other chemicals such as benzene and acrolein, typically found in Combustible Cigarette smoke.
sciencedirect.com/science/articl…
#SaferThanSmoking #SNEWS
Smokers using ECs over 4 wks exp. significant reductions in carbon monoxide, NNAL, and 2 of 8 measured VOC metabolites. Those who switched exclusively to ECs for at least half of the study period significantly reduced 2 add. VOCs.
academic.oup.com/ntr/article-ab…
#SaferThanSmoking #SNEWS
Subjects switching to e-cigarettes had significantly lower levels of urinary BoEs after 5 days. All groups experienced significant decreases in exhaled CO.
ncbi.nlm.nih.gov/pmc/articles/P…
#SaferThanSmoking #SNEWS
Under the conditions tested, Vype ePen e-cigarette aerosol was significantly less cytotoxic than reference 3R4F cigarette smoke.
tandfonline.com/doi/full/10.10…
#SaferThanSmoking #SNEWS
Regular vapers may avoid several harmful toxic chemicals that are typically present in the smoke of tobacco cigarettes.
ncbi.nlm.nih.gov/pmc/articles/P…
#SaferThanSmoking #SNEWS
No significant contribution of tested HPHC classes was found for the e-cigarettes.
sciencedirect.com/science/articl…
#SaferNicotine
#SaferThanSmoking #SNEWS
This study indicates that Ecigarette vapor is significantly less cytotoxic compared to tobacco cigarette smoke.
tandfonline.com/doi/abs/10.310…
#SaferThanSmoking #SNEWS
Within the study limitations, EC use may help smokers attenuate cigarette consumption or remain abstinent, as well as reduce their post-cessation weight increase.
mdpi.com/1660-4601/15/4…
#SaferThanSmoking #SNEWS
Some vapers are reporting that vaping is helping to mitigate weight gain after stop smoking. There are potential mechanisms by which vaping could facilitate weight control these include taste, mouthfeel, and behavioral replacement.
dspace.stir.ac.uk/bitstream/1893…
#SaferThanSmoking #SNEWS
Biomarkers of inflammation and oxidative stress in exclusive e-cigarette users are similar to former smokers and never-smokers, and lower than those of exclusive cigarette smokers.
pubmed.ncbi.nlm.nih.gov/34289969/
#SaferThanSmoking #SNEWS
ENDS products expose users to much lower levels of toxicants compared with cigarette smoking.
#SaferNicotine
accp1.onlinelibrary.wiley.com/doi/10.1002/jc…
#SaferThanSmoking #SNEWS
Many, including this article’s authors, believe that vaping can benefit public health, given substantial evidence supporting the potential of vaping to reduce
smoking’s toll. #TheSRNTFifteen
ajph.aphapublications.org/doi/10.2105/AJ…
#SaferThanSmoking #SNEWS

"Changes in biomarkers after 180 days of tobacco heating product use"

Our findings support the notion that the deleterious health impacts of cigarette smoking may be reduced in smokers who completely switch to using THPs.

link.springer.com/epdf/10.1007/s…

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