Prof. Christina Pagel Profile picture
Sep 29, 2021 20 tweets 9 min read Read on X
THREAD (a bit delayed) on UK & covid:

TLDR: flattish cases overall are masking differences between nations, regions & age groups. And we're still out of whack with Europe.

1/20
Vaccination update to start:
we've got good vaccination coverage - and excellent in older age groups.

Almost 60% of 16/17 year olds have had one dose of vaccine in England (higher in Scotland). BUT 2/20
There are big gaps in full vaccination uptake between the most and least deprived communities, and lower uptake in ethnic minorities.

This hasn't really improved over the last 6 months - whatever is being tried doesn't seem to be working. 3/20
On tests - the number of lateral flow tests done (or rather, reported!) has really varied with big "back to school" spikes that then drop off.

We're seeing that again now - and the drop off is mainly in students and not staff. Hard to say how this affects case numbers. 4/20
Cases are going up again in the UK - and we've now had substantially more confirmed cases in the Delta wave than the Alpha one. In a few weeks we'll have had more cases than we had between Sept 2020 and May 2021. 5/20
Yes hospitalisations and deaths are much lower than Jan peak - but they are still higher than a year ago and all these cases will be lead to many people develop long covid unfortunately, including some children. 6/
Hospitalisations are going down in all nations (good!) and deaths might just be starting to go down too - although we've been averaging over 130 a day for several weeks now and over 8,000 people have died since 1 July. 7/20
By nation, cases are going up in Wales and England but dropping in Scotland and dropping more slowing in NI.

Similar pattern seen in ONS infection survey (but Scotland not dropping yet - always takes a few weeks for drops in cases to show in ONS) 8/20
Regionally, cases are high all over Wales and in England concentrated in the Midlands and Yorks - lowest of all in London (!).

That pattern is seen in positivity rates too so it's not just testing. 9/20
Cases in Under 15s in Scotland remain high but have come down quickly over the last 10 days or so - and we are seeing a drop in admissions in children too which is good.

But a *lot* of children were infected in the first month of term - over 5% of all children under 15. 10/20
And we are seeing that hospital admissions in their parents' generation have been going up - in fact are higher now than they've ever been in the pandemic despite high vaccination. 11/20
In Wales, cases have been going up steeply in under 17s.

In N. Ireland, we've seen similar record breaking rates in 5-14 year olds. 12/20
In England, case rates in 5-14 are higher than their July peak - about 1.4% of all 10-14 year olds tested positive last week!

Cases also going up again in 15-19 year olds.
And in 30-59 yr olds - the ages most likely to be parents of school children. Following Scotland? 13/20
Hospitalisations in 6-17 year olds were dropping steeply at the beginning of September (corresponding to the late Aug flattening in cases?) but are now rising steeply again - only children have rising admission rates at the moment. 14/20
The number of children testing positive this term has already almost exceeded the number testing positive over the whole of the summer term. (158K vs 172K).

Estimates of Long Covid in kids range from 2%-14% - even 2% of 158K is 3,000 children developing Long covid... 15/20
ONS infection survey (to 18 Sept) also shows cases highest and rising in school age children. over 1 in 50 children had Covid that week. 16/20
Many of these cases could have been prevented with vaccination over the summer. It already looks like it (+ prev infection?) *might* be having an impact in 16-18 year olds...

at least they're the only year groups where cases fell over last 2 weeks instead of climbed. 17/20
Other countries that vaccinated teens are not seeing big back to school spikes in teens (but some are in primary school kids). E.g. Ireland... where cases in teens much lower than England but primary school kids about the same... 18/20
In fact many countries in Europe are not seeing big surges in children - a combination of vaccination (starting at different times over summer) and mitigations in schools (bubbles, masks, ventilation) & lower community case rates. 19/20
So there we are - rising cases in kids & their parents' generation, falling cases elsewhere, A high burden of Covid continues.

I don't know how vax in teens, some immunity from high infections this summer plays out against autumn & people returning to normal behaviour. 20/20

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More from @chrischirp

Jul 23
THREAD:
I wrote about Baroness Hallett's Inquiry Module 1 report for @bmj_latest .

She found that there was *never* a plan to keep a pandemic death toll down - I discuss this and what it means going foward.

Main points below: 1/14 Image
The headline most seen is that the UK planned for the wrong pandemic.

While it is true that was far too narrow a focus on a flu pandemic, that is not the most telling bit.

To me the most telling bit, is what the plan did NOT do 2/14


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The issue is less the wrong disease, but that there was never a plan to prevent one at all – of any disease type.

The plan was *never* about reducing the number of pandemic deaths. 3/14 Image
Read 14 tweets
Jul 19
Quick thread on current Covid situation in England and Long Covid.

I have Thoughts about the Inquiry Report published yesterday but am still trying to organise them.

TLDR: high Covid levels remain, Long Covid remains 1/11
This wave is not over. While the number of admissions with Covid remains lower than the autumn/winter waves, it has now remained highsh for several weeks.

This means there are a lot of people out there getting sick - and having their work, plans and holidays disrupted. 2/11 Image
Scottish wastewater data to 9 July shows a sharp decrease, suggesting that prevalence might be on its way down.

Obviously Scotland and England can have different dynamics, but it’s the best we’ve got as long as England refuses to analyse its own wastwater. 3/11 Image
Read 12 tweets
Jul 3
THREAD: Given tomorrow's election, I've been thinking about our nation's (poor) health, the wider determinants of health and how these have worsened and what it means for policy....

TLDR: worrying only about NHS & social care is missing the point

let's dive in... 1/25
The UK has a health problem. After steady gains in life expectancy for decades, it flatlined during the austerity years and fell for the first time this century with the Covid pandemic.

The number of people out of work for long term sickness is near record levels. 2/25
There are huge inequalities between rich & poor. Boys born in the most deprived areas can expect to die almost 10 years earlier than their peers in the least deprived areas.

Even worse, they can expect to spend 18 fewer years of their life in good health (52 vs 70 years) 3/25 Image
Read 38 tweets
Jun 4
As ever, I am getting lots of pushback.
Here is a compilation of the European countries I've found with recent wastewater data. Some are going up a bit, some down a bit, some are flat, none are anywhere near previous peaks.
I can't see anything here to be panic anyone. 1/3
Image
I can't find the dashboard for Spain, but others saying it is in a wave. Perhaps it is. England has just had one - the last data we had (a couple of weeks ago from Bob Hawkins) looked as if our wave had peaked.
So, I'm not seeing reason to think things are terrible here! 2/3 Image
Yes there are new variants growing right now. They are not growing faster than JN.1 grew in December and that wave did not end up as bad as feared.
Clearly it remains true that Covid is NOT a seasonal disease (unlike Flu and RSV)
3/3
Read 5 tweets
May 8
Quick thread on the Astra Zeneca (AZ) covid vaccine since it's been in the news today.

TLDR there isn't a new "smoking gun", the AZ vax was one of first and cheapest, it saved millions of lives globally, there are better vax out there now, adapted to new variants 1/9
the AZ vaccine was one of the first approved at the end of 2020, cheaper than Pfizer, and - importantly - easier to administer in lower resource settings as it didn't require super low temperatures for storage 2/9
In most countries it was first rolled out in older adults. As it was rolled out in younger adults, a *very rare*, serious, side effect was noticed - it could cause deadly blood clots

This was spotted quickly and studied. Vax monitoring did its job. 3/9 Image
Read 11 tweets
Apr 2
A short thread on why this is not a scary chart and why all the evidence suggests that there is not much Covid around right now. 1/6 Image
the above chart is recorded covid hospital admissions / reported covid cases. It is close to 100% now *because basically only hospitals can report cases since Feb 2024*

It is to do with changes in case reporting and NOT hospital testing
2/6
In fact hospital testing has been steady since the change in testing a year ago (only symptomatic patients get tested now).

The % of people PCR tested who have Covid is 4% - there is no evidence that there are loads of symptomatic people in hospital being missed. 3/6
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Read 6 tweets

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