Thread by @MetroUK

Two scientists have won the Nobel Prize in medicine for their discoveries into how the human body perceives temperature and touch.

Their revelations could lead to new ways of treating pain or even heart disease.

metro.co.uk/2021/10/05/nob…

Americans David Julius and Ardem Patapoutian identified receptors in the skin that respond to heat and pressure.

Their work is focused on the field of somatosensation, which explores the ability of specialised organs such as eyes, ears and skin to see, hear and feel.

‘This really unlocks one of the secrets of nature,’ said Thomas Perlmann, secretary-general of the Nobel Committee, in announcing the winners. ‘It’s actually something that is crucial for our survival, so it’s a very important and profound discovery.’

The committee said Prof Julius, who was born in New York and now works at the University of California at San Francisco, used capsaicin, the active component in chili peppers, to identify the nerve sensors that allow the skin to respond to heat.

Prof Patapoutian, who was born in Lebanon and now works at Scripps Research Institute at La Jolla, California, found separate pressure-sensitive sensors in cells that respond to mechanical stimulation.

The choice of Prof Julius and Prof Patapoutian underscored how little scientists knew about how our bodies perceive the world before their discoveries – and how much there still is to learn, said Oscar Marin, director of the MRC Centre for Neurodevelopmental Disorders at KCL.

‘While we understood the physiology of the senses, what we didn’t understand was how we sensed differences in temperature or pressure,’ Prof Marin said.

‘Knowing how our body senses these changes is fundamental because once we know those molecules, they can be targeted. It’s like finding a lock and now we know the precise keys that will be necessary to unlock it.’

Prof Marin said the discoveries opened up ‘an entire field of pharmacology’ and that researchers were already working to develop drugs to target the receptors they identified.

He predicted that new treatments for pain would probably come first, but that knowing how the body detects changes in pressure could eventually lead to drugs for heart disease, if scientists can figure out how to alleviate pressure on blood vessels and other organs.