1/ The Kaiser Permanente @aboutKP data (see tweet below) has now been published.

Vaccine effectiveness of 2 doses of Pfizer COVID vaccine.

On the left: VE vs infection drops over time
On the right: VE vs hospitalization holds steady over time

thelancet.com/journals/lance…
2/ Vaccine effectiveness of 2 doses of Pfizer COVID vaccine VERSUS INFECTION:
- all 12+: 88% in 1st month after vaxx➡️47% after 5 months
- among 65+: 80% in 1st month after vaxx➡️43% after 5 months
3/ Vaccine effectiveness of 2 doses of Pfizer COVID vaccine VERSUS HOSPITALIZATION:
- all 12+: VE vs hospitalization 87% in 1st month after vaxx➡️88% at 5 months

NO WANING OF PROTECTION AGAINST HOSPITALIZATION.
4/ Vaccine effectiveness of 2 doses of Pfizer COVID vaccine VERSUS INFECTION was lower for Delta variant (75%) than for other variants (91%).

At 1 month:
93% vs Delta at 1 month
97% vs other variants

At 4 months:
53% vs Delta
67% vs other variants

Similar rate of decline.

• • •

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More from @celinegounder

6 Oct
1/ As of early April 2021, there were almost 400K COVID cases and ~2.5K COVID deaths among U.S. prison inmates.

jamanetwork.com/journals/jama/…
2/ The risk of COVID among prisoners was more than 3x higher than for the general population (reaching 5x higher in Dec/Jan 2020).

The risk of death from COVID was 2.5x higher than for general population (reaching 2.7x higher in Dec/Jan).

jamanetwork.com/journals/jama/… Image
3/ This is cruel and unusual punishment.

No one deserves to be exposed to SARS-CoV-2.
Read 6 tweets
5 Oct
I'm honored to be advising @graphite_health,
a non-profit company transforming digital health care:

prnewswire.com/news-releases/…
By making data interoperability easy and affordable, @graphite_health facilitates the rapid adoption of digital health solutions.
.@graphite_health is creating a secure and open digital app marketplace. This will bring significant efficiencies to health systems’ operations, create a more modern & convenient patient experience, & make it easier for digital health entrepreneurs to scale their solutions.
Read 4 tweets
5 Oct
1/ COVID outbreak at a hospital in Israel:
eurosurveillance.org/content/10.280…

Some takeaways:

- Surgical masks don't prevent all transmission. We need to up our mask game and use KN95, KF94 or better masks.
2/
- Patients should have private rooms. This would improve infection control, privacy, and the ability of patients to get the rest they need.
3/
- We need universal precautions in hospitals. Staff should be wearing N95 masks and goggles/faceshields regardless of whether the patient is known to have COVID or not.
Read 4 tweets
29 Sep
1/ Such an important piece by @edyong209:
theatlantic.com/health/archive…
Our health system is broken.
Health system isn't synonymous with healthcare.
The healthcare industry isn't designed to fight pandemics.
2/ We don't value public health in this country.
washingtonpost.com/outlook/2020/0…
We don't value PUBLIC in this country.
We don't think we're all in it together.
3/ Health is SOCIAL, not individual.
Biomedical interventions don't fix social problems.
Read 5 tweets
28 Sep
1/ What do we know about mixing & matching COVID vaccines (aka heterologous prime-boost)?

Clinical trial data coming out soon.

c-span.org/video/?c497926…
2/ @NIH @NIAIDNews
Phase I/II clinical trial of boosting 12+ weeks
after 2 Moderna, 2 Pfizer, or 1 J&J
- To assess safety & reactogenicity
- To assess the breadth of humoral immune responses
clinicaltrials.gov/ct2/show/NCT04…
3/ They're studying all possible combinations:

1 J&J➡️1 Moderna
1 J&J➡️1 J&J
1 J&J➡️1 Pfizer
2 Moderna➡️1 Moderna
2 Moderna➡️1 J&J
2 Moderna➡️1 Pfizer
2 Pfizer➡️1 Moderna
2 Pfizer➡️1 J&J
2 Pfizer➡️1 Pfizer

With follow-up 14d, 28d, 3m, 6m, 12m after the booster dose.
Read 4 tweets
28 Sep
1/ Merck/Ridgeback, Pfizer, & Roche/Atea all have oral antiviral pills for the treatment of COVID in phase II/III clinical trials.

We anticipate results in the next couple of months with submission to the @US_FDA to follow soon thereafter.

But will these be game-changing?
2/ Remdesivir & monoclonal antibodies, both therapeutics for COVID, haven't been game-changing.

It's BEST to prevent COVID with VACCINATION.

But it's good to have COVID therapeutics as a backup measure, especially for older & more vulnerable or immunocompromised people.
3/ COVID drugs work by blocking the machinery that allows the virus to replicate. This reduces the viral load and the duration of infection. But if the damage has already been done, COVID drugs won't reverse that.
Read 5 tweets

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