Estrogen in itself is pro-GABA and neuroprotective. Estrogen dominance or, more accurately, the imbalance between hormones, metabolites, and neurosteroids is anti-GABA or excitatory. A handful of the estrone metabolites is more specifically anti-GABA.
Serotonin is both inhibitory and excitatory depending on receptor and subreceptor unit site binding, typically tending towards more inhibitory, or pro-GABA. Hence why increasing it is effective in cases of obsessive-compulsive disorder and anxiety.
Nitric oxide in itself is pro-GABA, peroxynitrites without being effectively neutralized or recycled are anti-GABA.
This has been researched and common knowledge since the 1970s - 1980s. Not really so common anymore, of course. It’s not as profitable as a lifetime pharmaceutical prescription.
This is another major reason why I recommend investing in term insurance if you choose to ignore circadian rhythm and light environment.
Disturbed circadian rhythm of the intrarenal renin-angiotensin system: relevant to nocturnal hypertension and renal damage link.springer.com/article/10.100…