Why does the UK currently have 6-fold hospital admissions and a 3-fold higher death rate compared with Europe? ft.com/content/345825…@FT@mroliverbarnes@jburnmurdoch@danieldombey
Among possible explanations, two that stand out are less use of mitigation measures /1
And less vaccination of kids, age 12-17
More reliance on Astra Zeneca vaccines offered as another possible contributing factor
Another potential explanation is that the UK vaccinated earlier than rest of Europe, and therefore has manifest more waning of protection, especially among older people
Graphs by @jburnmurdoch
Now @TheEconomist weighs in on this with similar ideas economist.com/graphic-detail…
More waning from earlier vaxxing is a possible factor. The AY.4.2 variant is not the explanation.
The UK has done far better than the US for uncoupling cases from hospitalizations and deaths
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As I wrote in SUPER AGERS, the immune system is the key to modulating our aging process and the opportunity to extend healthspan. Today @NatureAging 7 new articles, summarized here, that reinforce its central role nature.com/articles/s4358…
The new special issue @ScienceMagazine features Immunity with 4 outstanding review papers, 5★
Our immune system over the lifespan, sex differences, influence on physiology, and host antiviral defenses science.org/toc/science/cu…
We've learned a lot more about the principal drivers of age-related diseases in the past few weeks. And that leads to a unified model to pull it all together. (open-access)
I review 4 new reports, summarized here: 1. The proteins from senescent cells predict age-related clinical outcomes 2. A new epigenetic age clock connects the dots between aging, the immune system, inflammation and lifestyle factors 3. People with a fast pace of aging had an increased risk of cognitive impairment, age-related diseases, disability, and mortality 4. The Importance of “Immune Resilience” for Healthspan
And present a unified I/I model for what we now know
Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is favorably affected by exercise and likely many other lifestyle factors.
Here’s (almost) everything we know about it. In Ground Truths (link in my profile d/t X-suppression)
A major @Nature paper this week found a significant decline in dementia after an outdated Shingles vaccine.
I've reviewed the study and many other relevant ones in a new Ground Truths (link in profile)
A Table from the post
The effect in the 2 natural experiments differed substantially by sex with the benefit predominant in women
The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence
"implications are profound"
New @Nature nature.com/articles/s4158… nature.com/articles/d4158…