Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
Mg2+ Papi, the BowTied Mg2+ Profile picture
@Grimhood
Oct 19, 2021 • 4 tweets • 1 min read • Read on X
Dark circles under the eyes are a result of circadian dysregulation, fatty acid dysregulation, and copper-iron metabolism dysregulation.

Too little sunlight, too much artificial light especially at night.
Eat more seafood, eliminate industrialized vegetable/seed oils and fast food.
Unbound copper and iron accumulation in tissue. Increase magnesium, retinol, BOUND copper, zinc, vitamin D (midday UVB sunlight exposure), vitamin C, thiamine, riboflavin, niacin, B6, folate, and cobalamin intake.
Inositol hexaphosphate/IP6 and melatonin (fix circadian biology, see the sunrise every single day) can help to reduce the hydroxyl radical production (iron oxidation).

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Mg2+ Papi, the BowTied Mg2+

Mg2+ Papi, the BowTied Mg2+ Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @Grimhood

Mg2+ Papi, the BowTied Mg2+ Profile picture
Dec 28, 2024
A major flaw I’ve found behind the “seed oil/PUFA = obesity” theory is that there is this mechanism confabulated regarding linoleic acid having a pro-endocannabinoidergic effect via CB1 receptor agonism (this part is true), but the faulty thinking here is that this can be extrapolated to THC activity in cannabis producing the “munchies” in regards to lack of satiety induction and the drive to continue eating.
There is also the theory that PUFA, specifically linoleic acid, is the sole cause of producing depression, which would go completely against the above theory. If we’re using THC’s pharmacology as the basis for these theories, how is it that linoleic acid is also the cause of depression if CB1 agonism generally produces a very strong anti-depressant effect, including via simply increasing endogenous endocannabinoid activity via resistance and/or cardio exercise?
Not only are there two totally different and separate mechanisms in which linoleic acid and THC influence CB1 receptors (LA metabolizing to arachidonic acid metabolites which are used to synthesize endogenous endocannabinoids, anandamide and 2-arachidonoylglycerol, and THC via direct partial non-selective activation), there is also a significant difference between each of their degrees of binding affinity, protein binding and duration of receptor stimulation, influence on specific brain regions in regards to downstream effects on factors like ghrelin, dopamine release increasing pleasure derived from food consumption, and overriding of satiety signals such as leptin.
Read 6 tweets
Mg2+ Papi, the BowTied Mg2+ Profile picture
Dec 15, 2024
One of the key factors I notice with those with flagrant digestive issues are a severe aversion to any sort of bitter foods or herbs/vegetables.

These two factors will often go hand in hand, typically dating back to a childish palate and/or downregulated taste receptors that require a reset after a lifetime of a Stupid American or ultra processed diet.

Aside from chloride, zinc, trimethylglycine/betaine, thiamine, and potassium, tasting bitter foods/herbs on the tongue regularly helps to keep stomach acid production high via the bitter taste receptor on the tongue. Activating the bitter taste receptors stimulates the vagus nerve, which goes on to stimulate salivation (digestive enzymes begin during proper mastication/chewing), and gastric secretions (stomach acid and digestive enzymes in the stomach).

This is absolutely CRUCIAL to optimal digestion of proteins, fibers, and fats.
This is one key reason why I highly recommend to stop being a pussy and to taste herbs like black seed oil directly on the tongue, capsules and softgels eliminating a good portion of the potential benefits you could be experiencing.

Speaking of which, you can find a phenomenal quality black seed oil here: 100percentnaturals.co/products/100-p…Image
Image
This is equally important in those who need to eat frequent, generally protein-rich meals throughout the day to stimulate and maintain muscle protein synthesis, i.e. bulking, such as bodybuilders and power lifters.

You really need to ensure you’re getting sufficient micronutrient and herbal bitter/vegetable intake. Especially important in the off season and even during prep for contests so you’re getting the most out of your food intake while avoiding potential bloating and related digestive issues that can negatively impact performance and aesthetics.
Read 4 tweets
Mg2+ Papi, the BowTied Mg2+ Profile picture
Dec 13, 2024
The problem I have with natural T boosters is they’re largely squeezing out additional adrenal androgen output, vs gonadal/testicular. Adrenal androgen production making up only about 3% of total testosterone and DHT production systemically. Shilajit being a prime example of this phenomena.

An exception to this obviously being micronutrients that directly influence antioxidant capacity or hypothalamic-pituitary-testicular axis in the gonads and natural aromatase inhibitors, which reduces total systemic estradiol and interrupts the negative feedback loop on gonadotrophin production (luteinizing hormone/LH and follicle stimulating hormone/FSH) via HPTA.

I’ve yet to see this having a sustained effect on the HPTA and resulting androgen production without using that acute energy and motivation to make serious dietary, lifestyle, and environmental changes.
Such as subcutaneous and visceral fat loss, which downregulates aromatase expression, thus having a more sustained effect on relieving that negative feedback loop on HPTA function.

Providing a surplus of micronutrients and sufficient macronutrients/calories that will enable the testicles to produce gonadotrophins without interference from lack of energy or excessive reactive oxygen species production (ROS/oxidative stress).

Or seriously altering indoor light environment and sunlight exposure practices to provide the proper stimulus to HPTA via the retinohypothalamic tract and removing the negative stimulus that interferes with this and produces excessive ROS, that is artificial blue light and nnEMF/RF.
Any so-called “testosterone boosters” will only have an acute effect on androgen hormones at best, and more generally will have a greater effect on catecholamine or adrenal steroid production.
Read 5 tweets
Mg2+ Papi, the BowTied Mg2+ Profile picture
Nov 16, 2024
If you ignored my yearly warnings to START NOW on midday UV sunlight exposure and last winter ended up turning out rough for you, you need to read this so you don’t have to repeat it again.

You should only ever resort to supplements acutely to restore levels if deficient and below 30ng/mL on blood work, otherwise even if you just buy the Phillips bulbs and a basic set up instead of Sperti or a Chroma (safety and protection of the bulb is a highly concerning matter), you should be using UV light and I’ll tell you exactly why.
Cholecalciferol (vitamin D3 and what you think of when you hear “vitamin D”) is only ONE vitamin D complex metabolite of literally dozens.

There are dozens of different metabolites, both active and used as storage, of vitamin D that are highly important factors for vitamin D receptor (VDR) binding, organ receptor affinity and specificity, storage capacity, interchangeability throughout different contexts (i.e. low external UV, external temp dropping, healthy people demonstrating their own UV spectrum emission internally to influence the metabolites produced from dietary intake via cold exposure, etc.), and antiviral effects.Image
UVB exposure to the 7-dehydrocholesterol content of the skin forms pre-vitamin D3, which is unstable and undergoes thermal isomerization to vitamin D3.

Supplements won’t generate lumisterol and tachysterol from further UVB exposure to the pre-vitamin D3 formed in the skin.

In the presence of ROS, photosensitizing agents, and longer UV exposure, we also get 5,6-trans-vitamin D3, suprasterols, isotachysterols, and cholesta-5,7,9(11)-triene.
Read 6 tweets
Mg2+ Papi, the BowTied Mg2+ Profile picture
Nov 6, 2024
Try 97%. Only 3% of diseases are ever truly “genetic”.
x.com/grimhood/statu… x.com/grimhood/statu…
x.com/oliviercantin/… x.com/oliviercantin/…
Read 11 tweets
Mg2+ Papi, the BowTied Mg2+ Profile picture
Jul 26, 2024
Omega-3 fatty acids also generate endocannabinoids, yet aren’t associated with obesity. Quite the opposite in fact.

Cannabis usage is associated with lower BMI than non-users.
I’ve seen the theory that this association with cannabis usage and lower BMI is caused by a downregulation of CB1 receptors via chronic intake, but the same downregulation would occur with linoleic acid that gets stored in subcutaneous fat as they’re released and metabolized: a chronic supraphysiological activation of CB1R by endocannabinoids.
That’s not to mention the numerous other herbs and spices with agonistic activity at CB1R that are associated with lower BMI and reduced risk of obesity as well.

Lots of holes in this theory, back to the drawing board.
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

Send Email!

:(