#ASHG21 TA: Tiffany Amariuta.
Modeling tissue co-regulation to quantify tissue-specific contributions to disease heritability. [ dropping in the middle of it ]
Modeling tissue co-regulation to quantify tissue-specific contributions to disease heritability. [ dropping in the middle of it ]
#ASHG21 TA: TCSC applied to real traits. 25 GTEx v8 tissues. 350-550 meta tissues and singular tissues. analyze 82 GWAS summary statistics. TCSC identifies 67 tissue trait pairs with non-zero heritability at 10% FDR.
#ASHG21 TA: TCSC reduces the number of trait-associated tissues within a tissue category by 67% because it accounts for tissue co-regulation.
#ASHG21 TA: In blood traits, IBD risk, alzheimers, red blood cell count, and total blood protein are found to be associated with the total blood expression
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