#ASHG21 KG: Kiran Girdhar.
Acetylated chromatin domains link chromosomal organization to cell and circuit level dysfunction in schizophrenia and bipolar disorder.
Acetylated chromatin domains link chromosomal organization to cell and circuit level dysfunction in schizophrenia and bipolar disorder.
#ASHG21 KG: Generated cell specific histone modified regions from controls postmortem brain samples. Enrichment of neuron specific histone peaks.
#ASHG21 KG: hyper acetylated peaks are enriched for schizophrenia and bipolar risk loci. Hypothesized that coordinated structure of histone peaks may be important in disease.
#ASHG21 KG: see cis-regulatory domains (CRDs) span width of 10kb - 10Mb. The CRDs are disrupted as a structural unit, not just an individual isolated peak.
#ASHG21 KG: trans interactions between CRDs show interactions of hyper- and hypoacetylated loci. Highest magnitude coefficient of heritability of schizophrenia was with fetal specific CRDs
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