Thread by @celinegounder

1/ On mixing & matching COVID shots, by @KatherineJWu in @TheAtlantic:
theatlantic.com/health/archive…

If you're eligible for an additional dose of COVID vaccine, you can get whichever you want (Pfizer, Moderna, or J&J).

2/ There were only ~50 people in each 9-arm of the NIH mix & match study for a total of less than 500.

Moderna was given full-dose (100 mcg) in the NIH mix & match study, not half-dose (50 mcg) as approved for boosters.
Higher dose➡️more side-effects

https://twitter.com/celinegounder/status/1448356527702675458?s=20

3/ Many other caveats outlined here:

https://twitter.com/celinegounder/status/1448356527702675458?s=20

4/ FWIW, I got my 1st dose of Pfizer in December and my 2nd dose in January.

I am a healthcare worker. I am under 65 and don't have chronic medical conditions.

I have not gotten a booster because my risk of severe disease, hospitalization, & death has not increased.

5/ If there's evidence that immunity to vaccination in people like me is waning and that I'm at increased risk of severe disease, hospitalization, or death, I will seek out a 3rd dose of vaccine, and that will likely be a Pfizer shot because that's what I would be offered.