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Kashif Pirzada, MD Profile picture
@KashPrime
Oct 25, 2021 • 8 tweets • 5 min read • Read on X
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Today many hospitals in the Toronto area will start to offer the Regeneron Monoclonal cocktail for the treatment of Covid-19. This is a ‘passive vaccination’ - providing artificial antibodies that otherwise develop naturally in vaccinated people.
I went over in some detail how these treatments are created last year. They are produced in a process that shares many steps with production of mRNA vaccines. One of them, @AbCelleraBio's Bamlanivimab, is designed in Canada and marketed by Eli Lilly.
They also represent a crucial part of an ‘immune system for society’ where we can handle new threats and variants that evade our vaccines. These are local companies that are going to help us fight these threats: @IncResilience @AbCelleraBio @PrecisionNano @Novavax @medicagoinc
It's unfortunate it took so long to use these drugs, they have been used for 8 months in the US. Our gatekeepers keep searching for ‘perfect’ evidence of effectiveness, as they did for masks & ventilation upgrades. Perfection can often be the enemy of good
theglobeandmail.com/canada/article…
I’ve been advocating for their use for the better part of the year, and worked with colleagues to build interest in them last summer. Sadly there wasn't much uptake.
Many of the patients that we saw succumb in the third wave in Toronto could have benefited from this treatment, but across the border in the US it was easily available. Thanks to @peesker for covering this story in the CBC:

cbc.ca/news/canada/ha…
Lilly’s enhanced antibody cocktail is still awaiting approval in Canada, but, ironically for a Canadian-made drug, has emergency use authorization in the US but not here.
canada.ca/en/health-cana…
Criteria differ at different hospitals, this is one from a Toronto hospital.
Regardless if you are unvaxxed or vaxxed, if you get sick and are within the treatment window, check with your local hospital if you qualify for 'passive immunization' with monoclonals ASAP

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More from @KashPrime

Kashif Pirzada, MD Profile picture
Aug 10
Probably the most important article you'll read all year, by @omeraziz12 in the @globeandmail
Canada is in serious trouble, and Aziz hits the nail on the head on the causes:

- Deep incompetence by politicians, who resort to PR management over making decisions. Parliament is deeply dysfunctional, with Question Period a joke, and committee hearings a farce. Trudeau but also the provincial premiers have much to answer for. Many of our leaders come from legacy wealthy backgrounds and have absolutely no idea how difficult they've made life for Canadians.

"What I realized soon thereafter was that this country was witnessing a systemic political failure, a complete inability of politicians to get change done in ways that manifested at the dinner table. An extreme form of PR and image-management had begun to take over delivering on policy in concrete ways − and the entire country was noticing. Nor was this an accident, the unfortunate consequence of polarization or inequality, but the deliberate result of multiple policy failures − as well as failures of will."

"Normally, in a democracy, social ills can be addressed by public officials. But Canada’s own political institutions have been riven by corruption and personal ambition. And now also potentially by foreign influence. Each controversy and scandal leads people away from crucial time and policy attention that could have been spent on fixing the country’s major issues. At the parliamentary level, most members of Parliament are so frightened of speaking for themselves that they are rendered powerless. This defies the very essence of the British parliamentary system, upon which Canada’s system is based, which empowers MPs to speak on behalf of their constituents and represent their true voice in the people’s chamber."

- Inattention to rising crime, especially rampant car thefts, a revolving door criminal justice system, neglect of the opioid crisis. We have the laxest justice system in the Western world. Causing someone's death will get you a 6 month sentence in one prominent example. America had mass incarceration, we have mass leniency.

"At some point, one would think that the deaths of so many innocent and vulnerable people would elicit outrage − yet life goes on as normal. Each life is precious, and when violent criminals get off easy, or without punishment at all, they learn the terrible lesson that this country does not take its own laws seriously, so why should they? When the law loses its power to deter crime, either because of prosecutors not moving forward with cases, or because of a general laissez-faire attitude toward violent crime happening in other neighbourhoods, it is the marginalized who are harmed most."

- Rising housing costs that has made nearly everyone, including me, to paraphrase A Bittersweet Symphony, a slave to massive mortgages until they die, or they are perennial renters.

"For many Canadians, the cost of living has become unaffordable. The average price of a house in the GTA is $1.1-million, and Metro Vancouver is around the same. There are certainly cheaper places to live, but the average cost of a rental in Canada has reached record highs − more than $2,100 a month. According to one major study, Canada needs to build an additional 3.5 million homes by the end of the decade and is currently only building around 200,000 a year."

- Violation of the social contract on immigration.
"In Canada, the social contract for years allowed more immigration to grow the economy, but this came with stringent criteria for who should be admitted. Today, there are more than 900,000 international students in Canada, a 170-per-cent increase over the past decade. Some of these students have been scammed by for-profit colleges. Others have been affiliated with fake schools, using their student visas as loopholes in the immigration system. The social system was unprepared for such an influx, though certain institutions benefited: colleges and universities got more fees; politicians touted rising immigration numbers; the landlord class got an endless supply of perpetual renters. Without any housing available, this has left the country unprepared to deal with multiple, overlapping economic and social crises."

Aziz asks What is the Canadian dream?
"It was a promise − less individualistic and gun-friendly than the American version, but no less ambitious. To me, the dream promised that every person here could have a decent shot at life, one that was better than that of their parents. There was emphasis on community and a strong focus on order and good government. The compact included the payment of higher taxes, and in exchange, the existence of world-class social institutions delivering for ordinary people. The immigration system worked because the same contract existed with immigrants − that they would work hard, play by the rules, become part of Canadian society through legal means, and in return, would become citizens of a highly functioning democracy where a good life was, if not guaranteed, then within reach.

The dream was based on fairness, on merit, on policies that worked. It promised breathable air and the bountiful resources of the second-largest country on Earth. It promised the principle of equality of opportunity, promised safety and peace and responsibility. It promised leaders who put the national and long-term interests of the country above their own partisan needs. The dream now feels like it’s on life support."

AmenImage
Link to the article here:
theglobeandmail.com/opinion/articl…
Read 4 tweets
Kashif Pirzada, MD Profile picture
Mar 6
Wanted to share with you something near and dear to my heart.
Today my colleagues and I are proud to launch the Canadian Covid Society. @CanCovSoc

Covid-19 is thankfully not the threat it once was, but there are still significant issues with having a new disease roughly 4x as bad as Flu (and much more contagious) floating around, which also disables a lot of people as well.

In Canada it was the 3rd leading cause of death 2020, 2021 and 2022. We have the Canadian Cancer Society, and Heart and Stroke foundation for the 1st and 2nd causes, it's time we have one for the 3rd leading cause of death.

It is perfectly natural to not want to deal with this issue anymore. But that's part of the problem isn't it?
Many of us have a visceral aversion to discussing it, perhaps a natural reaction to memories of the most traumatizing days of the pandemic. But the fact remains that it's still out there, that it will continue to cause strain on our health systems, disable people, and shorten life for many of us.

We need a national body that will keep advocating for things like updated vaccines and therapies, as well as common-sense fixes that prevent the spread of disease, like cleaner indoor air (which could have been very useful stopping this nasty measles outbreak we're having).

We need a national strategy to support and improve access to care for Long Covid sufferers, many of whom are simply unable to access any care for a devastatingly disabling condition. 2 out of the 3 Long Covid advocates we approached for our launch event were not able to attend due to illness, which should tell you something! There's no way to predict who will get it, when they'll get it, and there is no cure, yet.

We are organizing a virtual press conference for 1pm (ET) today, Wednesday March 6, 2024. A video stream will begin on Youtube, and this url will forward you there: . Journalists who wish to ask questions please send me a DM and I will send you instructions to join.

Our website is up at

You'll hear more from us as we grow the range of activities offered by the Society. We would love to share resources and help like-minded groups start national societies in their own countries. Would love to see and collaborate with an American Covid Society, a British Covid Society etc.

It is time that we create a permanent effort to fight this disease, and not have these efforts subject to political whims or a societal wish to indulge in denial.covidsociety.com
covidsociety.caImage
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As a national society, we will be bilingual and our launch event will be in both French and English
lapresse.ca/dialogue/opini…
Read 8 tweets
Kashif Pirzada, MD Profile picture
Nov 28, 2023
Life expectancy drops for a third year in a row

C19 is the third leading cause of death, behind heart disease and cancer, ahead of accidents/trauma.

Mortality overall is up 13% across all age groups compared to 2019, and increasing every year

This should be a huge scandal! Image
We are being robbed of precious life years, for no good reason except to maintain an unsustainable status quo. We are losing time with our loved ones, the economy is losing out on workers in their prime years, and there must be a better way.

Media article:
Statscan source:
and
Does this look like a trend that's slowing down?
Not to me Image
Read 6 tweets
Kashif Pirzada, MD Profile picture
Jun 13, 2023
So much truth in this one graphic.
True story, on a recent shift, I had to run and help a patient who had collapsed on our waiting room floor, short of breath. Hypoxemic. The family was diligent, and tested before coming, and lo-and-behold, they were positive. With some help, got… twitter.com/i/web/status/1… Image
I asked ChatGPT to summarize my feelings in verse, and it did an astonishing job:

In sorrow do I witness suffering's reign,
The public's decline, inflicted by this bane,
The young struck by blood clots, strokes untold,
Life's flame grows dimmer, as the years unfold.
Alas,… twitter.com/i/web/status/1…
Thanks to @RobbieMeriales for the illustration:
Read 5 tweets
Kashif Pirzada, MD Profile picture
Jun 7, 2023
Today wore an N95 mask outside for the first time ever, and found it really helpful for throat irritation and that annoying choking feeling. Doesn't help for eye irritation though. Would highly recommend.
If you've upgraded your home, workplace or school with enhanced ventilation and filtration to fight airborne illnesses, you're in luck: staying indoors will protect you. If not, you can jerry-rig some filters using commonly available parts:
If you've spent time in any congested Asian or African city, the feeling is both routine and hard to forget. Even more reason to push hard the energy transition away from polluting and global-warming contributing fuels around the world.
Read 6 tweets
Kashif Pirzada, MD Profile picture
Apr 3, 2023
Had the chance to speak to Katie Dangerfield of @globalnews about Covid-19 boosters and the lack of clarity and guidelines from our advisory bodies.

I'll explain some of my reasoning why I think regular (every 6-12m) boosters are a good idea for all age groups:

1) It's always… twitter.com/i/web/status/1…
The article on Global News:
globalnews.ca/news/9592598/c…
This post really speaks to the incoherence of national policy. As doctors we have to hold two very different ideas in our heads. Covid is 'over' and 'just a flu' has to live in the same meatspace as 'omg why is this young person with zero risk factors having a stroke', or 'why… twitter.com/i/web/status/1…
Read 4 tweets

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