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Billy Bostickson 🏴👁&👁 🆓 Profile picture
@BillyBostickson
Oct 30, 2021 • 30 tweets • 13 min read • Read on X
Scrolly
1. Ariadne's Thread - SARS Vaccines

Collection of SARS Vaccine papers for Maze addicts

How was the Minotaur born?
2. Immunogenicity difference between the SARS coronavirus and the bat SARS-like coronavirus spike (S) proteins
Peng Zhou,Zhenggang Han,Lin-Fa Wang, Zhengli Shi

ncbi.nlm.nih.gov/labs/pmc/artic…
3. Immunogenicity of the spike glycoprotein of Bat SARS-like coronavirus

Yu-xuan Hou,Cheng Peng, Zheng-gang Han, Peng Zhou, Ji-guo Chen, Zheng-li Shi

1https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7090579/
4. Following the thread
5. Recombinant receptor-binding domain of SARS-CoV spike protein expressed in mammalian, insect and E. coli cells elicits potent neutralizing antibody and protective immunity

ncbi.nlm.nih.gov/labs/pmc/artic…
6. Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection

ncbi.nlm.nih.gov/labs/pmc/artic…
7. A 219-mer CHO-Expressing Receptor-Binding Domain of SARS-CoV S Protein Induces Potent Immune Responses and Protective Immunity

ncbi.nlm.nih.gov/labs/pmc/artic…
8. Unravelling the Thread
9. Antigenicity and immunogenicity of SARS-CoV S protein receptor-binding domain stably expressed in CHO cells

ncbi.nlm.nih.gov/labs/pmc/artic…
10. Vaccine Design for Severe Acute Respiratory Syndrome Coronavirus

liebertpub.com/doi/10.1089/vi…
11. Recombinant Modified Vaccinia Virus Ankara Expressing the Spike Glycoprotein of Severe Acute Respiratory Syndrome Coronavirus Induces Protective Neutralizing Antibodies Primarily Targeting the Receptor Binding Region

ncbi.nlm.nih.gov/labs/pmc/artic…
12. Recombinant Modified Vaccinia Virus Ankara Expressing the Spike Glycoprotein of Severe Acute Respiratory Syndrome Coronavirus Induces Protective Neutralizing Antibodies Primarily Targeting the Receptor Binding Region

ncbi.nlm.nih.gov/labs/pmc/artic…
13. Minotaur emerges
14. Intranasal Vaccination of Recombinant Adeno-Associated Virus Encoding Receptor-Binding Domain of SARS-CoV Spike Protein Induces Strong Mucosal Immune Responses and Provides Long-Term Protection against SARS-CoV Infection

ncbi.nlm.nih.gov/labs/pmc/artic…
15. Effect of mucosal and systemic immunization with virus-like particles of severe acute respiratory syndrome coronavirus in mice (WIV, 2010)

ncbi.nlm.nih.gov/labs/pmc/artic…
16. Easy for a Mouse
17. A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

ncbi.nlm.nih.gov/labs/pmc/artic…
For whom does the Bell Toll?

Effects of Toll-Like Receptor Stimulation on Eosinophilic Infiltration in Lungs of BALB/c Mice Immunized with UV-Inactivated Severe Acute Respiratory Syndrome-Related Coronavirus Vaccine

ncbi.nlm.nih.gov/labs/pmc/artic…
19. For Ferrets and Monkeys!

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

ncbi.nlm.nih.gov/labs/pmc/artic…
20. SARS-CoV Spike Proteins Expressed by the Vaccinia Virus Tiantan Strain: Secreted SQ Protein Induces Robust Neutralization Antibody in Mice

liebertpub.com/doi/10.1089/vi…
21. Chimeric Minotaur
22. Chimeric severe acute respiratory syndrome coronavirus (SARS-CoV) S glycoprotein and influenza matrix 1 efficiently form virus-like particles (VLPs) that protect mice against challenge with SARS-CoV

ncbi.nlm.nih.gov/labs/pmc/artic…
23. Development of subunit vaccines against severe acute respiratory syndrome
Du, L., He, Y., Jiang, S., Zheng, B.-J.

journals.prous.com/journals/servl…
24. The Shadow
25. Potent neutralization antibody elicited in mice by SARS-associated coronavirus spike protein S1 domain

pubmed.ncbi.nlm.nih.gov/15640862/
27. The expression and antigenicity of a truncated spike-nucleocapsid fusion protein of severe acute respiratory syndrome-associated coronavirus

ncbi.nlm.nih.gov/labs/pmc/artic…
28. Truncated Recombinations, a Mouse's Nightmare
29. More
1. Studies of SARS vaccines
hkmj.org/abstracts/v14n…
2. Animal coronavirus vaccines: lessons for SARS
pubmed.ncbi.nlm.nih.gov/15742624/
3. SARS Vaccine Development
ncbi.nlm.nih.gov/labs/pmc/artic…
4.Vaccine Design for SARS
liebertpub.com/doi/10.1089/vi…
5. SARS Vaccination
cmi.ustc.edu.cn/1/3/193.pdf
30. From SARS 1 to SARS 2

A Review on SARS-CoV-2-Induced Neuroinflammation, Neurodevelopmental Complications, and Recent Updates on the Vaccine Development

ncbi.nlm.nih.gov/labs/pmc/artic…
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More from @BillyBostickson

Billy Bostickson 🏴👁&👁 🆓 Profile picture
Nov 8
@Daoyu15 @jhas5 @Fynnderella1 Not sure what your point is ragrding hACE2 mice infection.

Have you read all the other hACE2 mouse model papers that show SC2 infection.

I have!

Here are 15 of them, please read them:

1. Animal models for SC2 and SC1 pathogenesis & transmission

pmc.ncbi.nlm.nih.gov/articles/PMC87…
@Daoyu15 @jhas5 @Fynnderella1 2. Mouse Models for SC2 Infection

pmc.ncbi.nlm.nih.gov/articles/PMC85…

3. Highly susceptible hACE2-transgenic mouse model for SC-2 research

frontiersin.org/journals/micro…

4. Inducible hACE2 transgenic mouse model recapitulates SC-2 infection & pathogenesis in vivo

pnas.org/doi/abs/10.107…
@Daoyu15 @jhas5 @Fynnderella1 5. Mouse Model of SC-2 Infection & Pathogenesis

sciencedirect.com/science/articl…

6. Mouse models of lung-specific SC-2 infection

frontiersin.org/journals/immun…

7. Comparison of transgenic & adenovirus hACE2 mouse models for SARS-CoV-2 infection

tandfonline.com/doi/full/10.10…
Read 8 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Nov 7
@Ticklicker56 @Biorealism Yes, we thoroughy researched this issue some time ago.

Difficult to prove anything, but certainly raises suspicions.
@Ticklicker56 @Biorealism Interestingly, the E protein and nsp7 of ZC45 are 100% identical to those of SARS-COV-2.

Even Holmes (Wu et al., 2020) listed ZC45 as closest in Feb 2020 until the RaTG13 full genome was published in March

nature.com/articles/s4158…
@Ticklicker56 @Biorealism Phylogenetic trees and analysis from the early days

nature.com/articles/s4158…

What's unusual is that Wu & Holmes (2020) did NOT inlcude the RdRp of SC2 in the analysis

Holmes definitely knew of the RdRp of RaTG13 (4991) and RaTG13's sequence since 2018

x.com/tlitb/status/1… Image
Image
Image
Image
Read 6 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Oct 15
🧵The Censorship of an Innocent Monkey!

by the following Western "science" websites:

@biorxivpreprint

@medrxivpreprint

and Chinese news websites:

@globaltimesnews

@PDChina

Let's see what disturbs them so much that they have to censor certain comments?
1. @biorxivpreprint August 2024 Image
@biorxivpreprint 2. @biorxivpreprint 3 years ago Image
Read 38 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Oct 6
1. Spiked: The Hunt For The Origin of Covid-19

Good news @BlueAntMedia is going to publish it

Many #DRASTIC interviews including myself 🐵

"SPIKED tells the inside story of one of humanity’s biggest & most pressing mysteries: the debate over the origins of COVID-19"

Clip 👇
2. The Making of the Documentary (20 minutes)

"Unfolding like true crime, this detective story takes us deep into clashing conspiracy theories & partisanship while exposing the dangers posed by experiments regularly taking place in the world’s biolabs"

worldscreenevents.com/premieres/spik…
3. Our film is a true crime detective thriller

"It’s about the future of biotech and the next pandemic. We wanted to make a contentious story really exciting, with twists and turns, that covers the science but with a strong dramatic structure"

broadcastnow.co.uk/broadcast-netw…
Read 8 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Sep 14
1. "Baseless" = How the Media Gaslights You

The 4Ds: Dismiss, Distract, Distort, Dismay

7 posts with video evidence of cat eating by Haitian immigrants in the comments

and this is why they hate @X

Because their lies & propaganda are exposed

Their Masters have lost control!
2. A Haitian Woman in the US speaks out

3. Haitian-American, whose family members ate cats, SPEAKS OUT against illegal migration.

Read 12 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Sep 9
1. "For me with this data a lab origin is now more than likely" says @dr_louwen

Referring to ON876210 ( i think ;)



From authors of this paper (Submitted March 2020)

An Infectious cDNA Clone of SARS-CoV-2



h/t @Rebecca21951651 ncbi.nlm.nih.gov/nuccore/ON8762…
ncbi.nlm.nih.gov/pmc/articles/P…
2. From 2020 Paper

“icSars_CoV_2 retained the engineered molecular markers & did not acquire other mutations”.

@dr_louwen considers that:

1. This increases the validity of the genetic finding

2. This isolate is highly similar to the wild type isolate 2019-nCoV/USA_WA1/2020
@dr_louwen 3. Point 2 above refers to "ON876210"

(My mistake in Tweet 1)

Submitted (29-JUN-2022) in the USA

ncbi.nlm.nih.gov/nuccore/ON8762…
Read 4 tweets

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