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Billy Bostickson 🏴👁&👁 🆓 Profile picture
@BillyBostickson
Oct 30, 2021 • 30 tweets • 13 min read • Read on X
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1. Ariadne's Thread - SARS Vaccines

Collection of SARS Vaccine papers for Maze addicts

How was the Minotaur born?
2. Immunogenicity difference between the SARS coronavirus and the bat SARS-like coronavirus spike (S) proteins
Peng Zhou,Zhenggang Han,Lin-Fa Wang, Zhengli Shi

ncbi.nlm.nih.gov/labs/pmc/artic…
3. Immunogenicity of the spike glycoprotein of Bat SARS-like coronavirus

Yu-xuan Hou,Cheng Peng, Zheng-gang Han, Peng Zhou, Ji-guo Chen, Zheng-li Shi

1https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7090579/
4. Following the thread
5. Recombinant receptor-binding domain of SARS-CoV spike protein expressed in mammalian, insect and E. coli cells elicits potent neutralizing antibody and protective immunity

ncbi.nlm.nih.gov/labs/pmc/artic…
6. Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection

ncbi.nlm.nih.gov/labs/pmc/artic…
7. A 219-mer CHO-Expressing Receptor-Binding Domain of SARS-CoV S Protein Induces Potent Immune Responses and Protective Immunity

ncbi.nlm.nih.gov/labs/pmc/artic…
8. Unravelling the Thread
9. Antigenicity and immunogenicity of SARS-CoV S protein receptor-binding domain stably expressed in CHO cells

ncbi.nlm.nih.gov/labs/pmc/artic…
10. Vaccine Design for Severe Acute Respiratory Syndrome Coronavirus

liebertpub.com/doi/10.1089/vi…
11. Recombinant Modified Vaccinia Virus Ankara Expressing the Spike Glycoprotein of Severe Acute Respiratory Syndrome Coronavirus Induces Protective Neutralizing Antibodies Primarily Targeting the Receptor Binding Region

ncbi.nlm.nih.gov/labs/pmc/artic…
12. Recombinant Modified Vaccinia Virus Ankara Expressing the Spike Glycoprotein of Severe Acute Respiratory Syndrome Coronavirus Induces Protective Neutralizing Antibodies Primarily Targeting the Receptor Binding Region

ncbi.nlm.nih.gov/labs/pmc/artic…
13. Minotaur emerges
14. Intranasal Vaccination of Recombinant Adeno-Associated Virus Encoding Receptor-Binding Domain of SARS-CoV Spike Protein Induces Strong Mucosal Immune Responses and Provides Long-Term Protection against SARS-CoV Infection

ncbi.nlm.nih.gov/labs/pmc/artic…
15. Effect of mucosal and systemic immunization with virus-like particles of severe acute respiratory syndrome coronavirus in mice (WIV, 2010)

ncbi.nlm.nih.gov/labs/pmc/artic…
16. Easy for a Mouse
17. A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

ncbi.nlm.nih.gov/labs/pmc/artic…
For whom does the Bell Toll?

Effects of Toll-Like Receptor Stimulation on Eosinophilic Infiltration in Lungs of BALB/c Mice Immunized with UV-Inactivated Severe Acute Respiratory Syndrome-Related Coronavirus Vaccine

ncbi.nlm.nih.gov/labs/pmc/artic…
19. For Ferrets and Monkeys!

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

ncbi.nlm.nih.gov/labs/pmc/artic…
20. SARS-CoV Spike Proteins Expressed by the Vaccinia Virus Tiantan Strain: Secreted SQ Protein Induces Robust Neutralization Antibody in Mice

liebertpub.com/doi/10.1089/vi…
21. Chimeric Minotaur
22. Chimeric severe acute respiratory syndrome coronavirus (SARS-CoV) S glycoprotein and influenza matrix 1 efficiently form virus-like particles (VLPs) that protect mice against challenge with SARS-CoV

ncbi.nlm.nih.gov/labs/pmc/artic…
23. Development of subunit vaccines against severe acute respiratory syndrome
Du, L., He, Y., Jiang, S., Zheng, B.-J.

journals.prous.com/journals/servl…
24. The Shadow
25. Potent neutralization antibody elicited in mice by SARS-associated coronavirus spike protein S1 domain

pubmed.ncbi.nlm.nih.gov/15640862/
27. The expression and antigenicity of a truncated spike-nucleocapsid fusion protein of severe acute respiratory syndrome-associated coronavirus

ncbi.nlm.nih.gov/labs/pmc/artic…
28. Truncated Recombinations, a Mouse's Nightmare
29. More
1. Studies of SARS vaccines
hkmj.org/abstracts/v14n…
2. Animal coronavirus vaccines: lessons for SARS
pubmed.ncbi.nlm.nih.gov/15742624/
3. SARS Vaccine Development
ncbi.nlm.nih.gov/labs/pmc/artic…
4.Vaccine Design for SARS
liebertpub.com/doi/10.1089/vi…
5. SARS Vaccination
cmi.ustc.edu.cn/1/3/193.pdf
30. From SARS 1 to SARS 2

A Review on SARS-CoV-2-Induced Neuroinflammation, Neurodevelopmental Complications, and Recent Updates on the Vaccine Development

ncbi.nlm.nih.gov/labs/pmc/artic…
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More from @BillyBostickson

Billy Bostickson 🏴👁&👁 🆓 Profile picture
Nov 14
🧵Long live the lab-leak hypothesis!

1. The long awaited 293 questions for Dr. Ralph Baric have finally been completed and shared! Long live the quest for truth! You are hereby invited to read the sharpest, most lethal 293-question dossier ever built.

researchgate.net/publication/39…
🧵Long live the quest for truth!

2. When that day finally comes & Baric raises his right hand, every word in there will be waiting for him


@RandPaul @RandPaulReview @TulsiGabbard
@SenJoniErnst @R_H_Ebright @jhas5 @ydeigin @gdemaneuf @mentju4 @emilyakopphsgac.senate.gov/media/reps/cha…
@RandPaul @RandPaulReview @TulsiGabbard @SenJoniErnst @R_H_Ebright @jhas5 @ydeigin @gdemaneuf @mentju4 @emilyakopp 🧵3. Watch the video explainer here

Courtesy of Google Notebook LM

vimeo.com/1136899679
Read 6 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Nov 12
✴️MICROPLASTICS IN YOUR BRAIN?

1. "These tiny fragments were far smaller than cells and even smaller than many viruses. Some were close to the size of DNA strands. Under high magnification, she noticed small hooked shapes with sharp points.
✴️2. OVERLOOKED

"She realized that the plastic in human brains was not only present, but surprisingly small. The fragments were so tiny that common diagnostic tools could not detect them. Pathologists had likely been overlooking them for years."

msn.com/en-us/health/o…
✴️3. NONE WERE FREE

"The two original samples showed a strong link between plastic particles and dementia. As Bearer expanded her work to ten more donated brains, she found plastic in every single one. None were free of synthetic fragments."
Read 23 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Nov 6
🧵1. In the interview with @danaparish

Redfield stresses that the evidence points to lab creation for a reusable, aerosolized vaccine vector, with US complicity in funding/tech.

He says he is fed up with the cover-ups and predicts that full intel release would confirm this.
🧵2. Proof?

Unfortunately, there is no direct proof provided by Redfield in this new interview, but he cites engineering features, early data, and classified information.
🧵3. Summary of Redfield's Statements

(on SARS-CoV-2 Origins & Cover-Up)

He claims SARS-CoV-2 originated from GOF research in a lab and emphasizes a significant US role alongside China.

He views this as a major biosecurity failure with ongoing suppression of transparency.
Read 21 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Oct 30
🧵1. Critique of preprint: SARS-COV-2 like FCS hype

Media article 1

dailymail.co.uk/health/article…

Media article 2

straitstimes.com/world/coronavi…
🧵2. The Authors State:

"Of note, the spike protein of this novel bat coronavirus possesses a functional FCS at the S1/S2 junction with a unique amino acid sequence motif (RDAR) that differs from that found in SARS-CoV-2 (RRAR) by only 1 amino acid."

biorxiv.org/content/10.110…
🧵3. Two fatal flaws: Overreach & Undermine

A. The authors of this study on the BRZ batCoV from Brazil unfortunately overreach themselves when they connect it to SARS-CoV-2 origins.

B. The FCS evidence actually undermines the flawed hypothesis of direct bat to human emergence!
Read 13 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Oct 25
🧵1. Honest question

Did you try to read my pangolin coronavirus report but gave up because it was too long or too complex?

If you didn't see it, link is in next tweet

Help is at hand!

Thanks to Google's pretty amazing "notebook lm"

A video explainer

notebooklm.google.com/notebook/1b843…
🧵2. Just in case..

The massive report is here:

researchgate.net/publication/39…
🧵3. An updated brief explanation on Medium

The Pangolin-Mediated Laboratory Origin of SARS-CoV-2

medium.com/p/the-pangolin…
Read 8 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Oct 4
"The molecular biology capabilities of WIV & the genome assessment are consistent with the hypothesis that SARS-CoV-2 was a lab-engineered virus that was part of a bank of chimeric viruses in Zheng-Li Shi's laboratory at WIV that escaped from containment"

usrtk.org/wp-content/upl…
2. Hypothetical Laboratory Origin of SARS-CoV-2

Between 2017 and 2019, WIV created full-length a infectious clone in pBAC-CMV using an unpublished bat Coronavirus genome as template (BatCoVX)

page 85
3. Hypothesis 3:

Between 2017 and 2019, WIV created chimeric Bat-CoV-X viruses using the pBACCMV-BCOVX backbone and swapping out key cassettes with other bat Coronaviruses (RBD, RBM, etc.) and adding additional features such as a furin cleavage site
Read 15 tweets

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