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Billy Bostickson 🏴👁&👁 🆓 Profile picture
@BillyBostickson
Oct 30, 2021 • 30 tweets • 13 min read • Read on X
Scrolly
1. Ariadne's Thread - SARS Vaccines

Collection of SARS Vaccine papers for Maze addicts

How was the Minotaur born?
2. Immunogenicity difference between the SARS coronavirus and the bat SARS-like coronavirus spike (S) proteins
Peng Zhou,Zhenggang Han,Lin-Fa Wang, Zhengli Shi

ncbi.nlm.nih.gov/labs/pmc/artic…
3. Immunogenicity of the spike glycoprotein of Bat SARS-like coronavirus

Yu-xuan Hou,Cheng Peng, Zheng-gang Han, Peng Zhou, Ji-guo Chen, Zheng-li Shi

1https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7090579/
4. Following the thread
5. Recombinant receptor-binding domain of SARS-CoV spike protein expressed in mammalian, insect and E. coli cells elicits potent neutralizing antibody and protective immunity

ncbi.nlm.nih.gov/labs/pmc/artic…
6. Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection

ncbi.nlm.nih.gov/labs/pmc/artic…
7. A 219-mer CHO-Expressing Receptor-Binding Domain of SARS-CoV S Protein Induces Potent Immune Responses and Protective Immunity

ncbi.nlm.nih.gov/labs/pmc/artic…
8. Unravelling the Thread
9. Antigenicity and immunogenicity of SARS-CoV S protein receptor-binding domain stably expressed in CHO cells

ncbi.nlm.nih.gov/labs/pmc/artic…
10. Vaccine Design for Severe Acute Respiratory Syndrome Coronavirus

liebertpub.com/doi/10.1089/vi…
11. Recombinant Modified Vaccinia Virus Ankara Expressing the Spike Glycoprotein of Severe Acute Respiratory Syndrome Coronavirus Induces Protective Neutralizing Antibodies Primarily Targeting the Receptor Binding Region

ncbi.nlm.nih.gov/labs/pmc/artic…
12. Recombinant Modified Vaccinia Virus Ankara Expressing the Spike Glycoprotein of Severe Acute Respiratory Syndrome Coronavirus Induces Protective Neutralizing Antibodies Primarily Targeting the Receptor Binding Region

ncbi.nlm.nih.gov/labs/pmc/artic…
13. Minotaur emerges
14. Intranasal Vaccination of Recombinant Adeno-Associated Virus Encoding Receptor-Binding Domain of SARS-CoV Spike Protein Induces Strong Mucosal Immune Responses and Provides Long-Term Protection against SARS-CoV Infection

ncbi.nlm.nih.gov/labs/pmc/artic…
15. Effect of mucosal and systemic immunization with virus-like particles of severe acute respiratory syndrome coronavirus in mice (WIV, 2010)

ncbi.nlm.nih.gov/labs/pmc/artic…
16. Easy for a Mouse
17. A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

ncbi.nlm.nih.gov/labs/pmc/artic…
For whom does the Bell Toll?

Effects of Toll-Like Receptor Stimulation on Eosinophilic Infiltration in Lungs of BALB/c Mice Immunized with UV-Inactivated Severe Acute Respiratory Syndrome-Related Coronavirus Vaccine

ncbi.nlm.nih.gov/labs/pmc/artic…
19. For Ferrets and Monkeys!

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

ncbi.nlm.nih.gov/labs/pmc/artic…
20. SARS-CoV Spike Proteins Expressed by the Vaccinia Virus Tiantan Strain: Secreted SQ Protein Induces Robust Neutralization Antibody in Mice

liebertpub.com/doi/10.1089/vi…
21. Chimeric Minotaur
22. Chimeric severe acute respiratory syndrome coronavirus (SARS-CoV) S glycoprotein and influenza matrix 1 efficiently form virus-like particles (VLPs) that protect mice against challenge with SARS-CoV

ncbi.nlm.nih.gov/labs/pmc/artic…
23. Development of subunit vaccines against severe acute respiratory syndrome
Du, L., He, Y., Jiang, S., Zheng, B.-J.

journals.prous.com/journals/servl…
24. The Shadow
25. Potent neutralization antibody elicited in mice by SARS-associated coronavirus spike protein S1 domain

pubmed.ncbi.nlm.nih.gov/15640862/
27. The expression and antigenicity of a truncated spike-nucleocapsid fusion protein of severe acute respiratory syndrome-associated coronavirus

ncbi.nlm.nih.gov/labs/pmc/artic…
28. Truncated Recombinations, a Mouse's Nightmare
29. More
1. Studies of SARS vaccines
hkmj.org/abstracts/v14n…
2. Animal coronavirus vaccines: lessons for SARS
pubmed.ncbi.nlm.nih.gov/15742624/
3. SARS Vaccine Development
ncbi.nlm.nih.gov/labs/pmc/artic…
4.Vaccine Design for SARS
liebertpub.com/doi/10.1089/vi…
5. SARS Vaccination
cmi.ustc.edu.cn/1/3/193.pdf
30. From SARS 1 to SARS 2

A Review on SARS-CoV-2-Induced Neuroinflammation, Neurodevelopmental Complications, and Recent Updates on the Vaccine Development

ncbi.nlm.nih.gov/labs/pmc/artic…
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More from @BillyBostickson

Billy Bostickson 🏴👁&👁 🆓 Profile picture
Feb 25
1🧵DECLASSIFICATION TASK FORCE - COVID 19

This Task force will be working to obtain the declassification and the release of Covid-19 origins files over the next 6 months.

This is GOOD NEWS!

2 🧵X GOP Member Handles

Task Force on the Declassification of Federal Secrets

@GOPoversight
@realannapaulina
@RepLuna
@RepEliCrane
@NancyMace
@RepNancyMace
@timburchett
@RepTimBurchett
@RepBoebert
@laurenboebert
@RepEricBurlison
@RepBrandonGill
@realBrandonGill
@RepJamesComer
@GOPoversight @realannapaulina @RepLuna @RepEliCrane @NancyMace @RepNancyMace @timburchett @RepTimBurchett @RepBoebert @laurenboebert @RepEricBurlison @RepBrandonGill @realBrandonGill @RepJamesComer 3 🧵Video (1)

Luna Reveals What The Task Force On The Declassification Of Federal Secrets Will Investigate

“This will no longer be a task force that makes bold promises only to fade into irrelevance or send strongly worded letters”

youtube.com/watch?v=Hz3aZL…
Read 17 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Jan 29
@Ticklicker56 @angie_rasmussen @Dissenting2020 @DrStrangeLovett @Rebecca21951651 @All_New_to_This @VaughnMises @R_H_Ebright @Florin_Uncovers @ban_epp_gofroc @MJnanostretch @Muller_Lab @SolidEvidence @ydeigin @ciukzwil @tgof137 @StavaRune @VBruttel @FondueMean @tom335363 @BioSRP @stevenemassey @jbloom_lab @BallouxFrancois @Ayjchan @mattwridley Not sure what they have done since Burgdorfer's "swiss agent" experiments, apart from building tick moats & annoying locals

bitterrootstar.com/2013/01/about-…

Dr. Rasmussen can tell us or she can ask Dr. Trout

hcn.org/articles/in-mo…
@Ticklicker56 @angie_rasmussen @Dissenting2020 @DrStrangeLovett @Rebecca21951651 @All_New_to_This @VaughnMises @R_H_Ebright @Florin_Uncovers @ban_epp_gofroc @MJnanostretch @Muller_Lab @SolidEvidence @ydeigin @ciukzwil @tgof137 @StavaRune @VBruttel @FondueMean @tom335363 @BioSRP @stevenemassey @jbloom_lab @BallouxFrancois @Ayjchan @mattwridley RML expertise in biodefense inlcudes tick & flea agents, so I doubt she would want to discuss how many ticks they have or what they inject them with.

federalregister.gov/documents/2004…

In the bad old days they injected them with yellow fever & other nasties for dispersal by planes.
@Ticklicker56 @angie_rasmussen @Dissenting2020 @DrStrangeLovett @Rebecca21951651 @All_New_to_This @VaughnMises @R_H_Ebright @Florin_Uncovers @ban_epp_gofroc @MJnanostretch @Muller_Lab @SolidEvidence @ydeigin @ciukzwil @tgof137 @StavaRune @VBruttel @FondueMean @tom335363 @BioSRP @stevenemassey @jbloom_lab @BallouxFrancois @Ayjchan @mattwridley Also work of Jeffrey M. Grabowski

Biology of Vector-Borne Viruses Section, Laboratory of Virology, RML

Work on tick-borne pathogens at the Virology Lab at RML is funded by the Intramural Research Program, NIAID, NIH

Not for long, I think! @DrJBhattacharya
Read 15 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Jan 20
1. Latest Victim of Flo Debarre's "Doxxng" Crusade

Is ME!

I got a disturbing & threatening email, mentioning:

"room for negotiation about the name"

"1st story is often the one that sticks, even if it's not accurate..your chance to negotiate terms"

"continue over Signal" Image
2. Le Monde

The reporter she is working with, William Audureau @Willvs , seems a principled journalist and did not know of her nefarious doxxing activities against me and other members of DRASTIC and our supporters in Academia, of which he dissaproves. Image
@Willvs 3. Best way to deal with bullies is to expose them!

I thus emailed CNRS, Cyber Security Office & the Minister of the Interior to complain

presidence.secretariat@cnrs.fr
presse@cnrs.fr ,
b.retailleau@senat .fr @BrunoRetailleau
contact@cecyf.fr
fraude-bretic@interieur.gouv.fr Image
Image
Read 12 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Jan 2
An unexpected result in a UK Porton Down Study

"Participant 12" (maybe a soldier at Aldershot). after infection with SC2, over time experienced a substantial number of mutations suggestive of rapid evolution.

Yet he was healthy & not immunocompetent?

genomemedicine.biomedcentral.com/articles/10.11…
They don't consider the possibility of quasispecies viral swarms as a possible factor in Participant 12?

Quasispecies implications for virus persistence (Domingo, 1999)

pmc.ncbi.nlm.nih.gov/articles/PMC71…

Quasispecies theory & emerging viruses
(Sardanyes, 2024)

nature.com/articles/s4429… Image
Overview of Viral Quasispecies

sciencedirect.com/topics/immunol…

Quite good Wikipedia Page

en.wikipedia.org/wiki/Viral_qua…

Viral quasispecies (Andino & Domingo, 2015)

sciencedirect.com/science/articl…

Historical Perspective on the Quasispecies Concept (Domingo, 2021)

annualreviews.org/docserver/full…
Read 19 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Dec 29, 2024
🧵DTIC MIL WUHAN/COVID-19 DOCUMENTS

Just dumping these here like Santa!

Maybe you will find something of interest?

Maybe a lump of coal or a potato!

1. Novel Coronavirus 2019 (COVID-19): Q&A on Global Implications and Responses (May 14, 2020)

apps.dtic.mil/sti/pdfs/AD117…
2. Award Number: W81XWH-11-2-0148 (2013)

WIV, Wuhan University, Le Duc and GNL mentioned

TITLE: National Biocontainment Training Center

PRINCIPAL INVESTIGATOR: James LeDuc, PhD

University of Texas Medical Branch at Galveston

apps.dtic.mil/sti/pdfs/ADA61…Image
Image
Image
3. Features, Evaluation, & Treatment of Coronavirus

Tedious Paper

March 1, 2021.

apps.dtic.mil/sti/pdfs/AD112…
Read 14 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
Dec 24, 2024
1. Panama Canal in the News

Historical Perspective

On the many workers' lives lost trying to build it:

Who were they and where did they come from?
2. First Attempt (French)

In the 1880s, the French tried but failed to build a Panama Canal.

They finally gave up in 1889, after years of fighting a recalcitrant landscape, ferocious disease and spiralling costs

AND the deaths of 22,000 workers! .

archive.ph/8FqKiImage
3. From Suez to Panama

Ferdinand de Lesseps's success in building the Suez Canal in 1869 was utterly derailed by the abysmal failure of his subsequent effort to build the Panama Canal due to disease.

Bankruptcy!

800 thousand people had invested their savings in the project! Image
Read 26 tweets

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