Recognizing a need for boosters in vulnerable when it comes to Delta & recognizing their benefit - which thus far seems high (even if turns out to be temporary)…
Why are we still vaccinating w mRNA sequence of the now obsolete Wuhan strain when we know the sequence for Delta.
This is only half sarcastic as a question.
Is it purely bc full trials haven’t been completed? Is it bc we don’t agree w an added benefit of using a sequence matching the most common and destructive variant?
My opinion is there would be benefit (or at least equivalency)
If we continue to Reenforce a response to the 1st virus, we may find ourselves stuck in that version of a response when we do want to make an update to the vaccine later on. Better to stay current.
Also, we know Delta has evasive mutations vs original immune response
And yes. I do understand that the immune data does in fact show that there is a good response to the original version of the vaccine. I’m not saying we are doing harm. I do wonder though why not keep up to date. Use mRNA vaccines how they are touted to be used (simple updates)
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Millions have unfortunately already been infected - we can’t undo that
Let’s not ignore it but use it to our benefit
Data shows Infxn + 1 dose Is as good as 2 dose in uninfected
Here’s a simple strategy to conserve vax and reduce burden
Thread
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When kids show up to get their first dose of a vaccine, they are simultaneously offered an antibody test. The sample for the antibody test can be a simple mouth swab of the gums (or a blood draw - but I prefer a swab of gums personally since it’s painless and easy.
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Now that the kid has their first vaccine AND a sample for antibody test, there will be 3-4 weeks to confirm if the child has antibodies to COVID.
This long period of time offers tons of flexibility to ensure a highly accurate result is obtained - I’ll give examples below
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Q: “Can I get a flu vaccine at same time as a Covid vaccine?”
A: YES!
The immune system evolved to be able to respond to MANY targets simultaneously. Similar to parallel processes on a computer, the immune system has enormous parallel capability.
For example, in my research largely pre-COVID, we profile immune responses to pathogens and vaccines.
In a single vaccine or infection, the immune system responds to an enormous array of different “epitopes” on even one pathogen or vaccine.
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When we add additional vaccines to the mix, it simply adds an extra set of epitopes (the parts of the vaccine or pathogen that the immune system recognizes) and our amazing immune systems don’t miss a beat
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At the start of the pandemic, @JMRothberg
was one of the first to understand that we needed to get widespread access to rapid accurate and inexpensive Covid tests…
He came up with a prototype, put together a team of microbiologists & engineers and set out to develop a molecular (PCR like) test that could be used in the home, quickly…
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Fast forward 18 months and @DetectTest is an FDA authorized rapid molecular home test.
It’s an incredible feat going from 0 to EUA in 18 months. (Most molecular test companies existed for years preCOVID)…
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It’s OK to talk about the biological limitations of vaccines without being anti-vax
Ex:
Just bc we wish vaccines stop transmission, doesn’t make it so. Vax limit spread a bit, but we’ve known for months that breakthroughs are not rare and spread among vax is common
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Does this mean that COVID vaccines don’t work? Absolutely not. They work great… for what they were measured and authorized to do - stop disease.
They weren’t authorized for their ability to stop spread. Vaccines work! Let’s be open both about what they do and don’t do well
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The more we try to toe the line and not quite be open w the limitations of vaccines - often suppressing messaging about their limitations - the more those limitations come back to haunt us in the form of loss in confidence across the population in the whole vaccine program.
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