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Abdulla A. Damluji, MD, PhD Profile picture
@DrDamluji
Nov 4, 2021 • 5 tweets • 4 min read • Read on X
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SUGAR trial @TCTMD

Cre8 EVO stent (70-80 microm) vs Zotarolimus DES stent

Study population: Patients with diabetics

Outcome target lesion failure (TLF) at 1 year

Design - non-inferiority trial
Procedural characteristics

between Cre8 EVO vs Resolute
anti platelets
Ok lets not get this wrong

This one met non-inferiority criteria for risk of TLF at one year

Is this correct? @SVRaoMD 😁
This may be helpful recap

Re: where the confidence interval is in relation to the null (1) and non-inferiority margin

In Sugar trial, they actually established superiority of Ceo8 EVO stent over Resolute

Which is basically choice A below

Correct me if I am wrong, @SVRaoMD

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More from @DrDamluji

Abdulla A. Damluji, MD, PhD Profile picture
Mar 1
2025 ACC/AHA/ACEP/NAEMSP/SCAI
Guideline for the Management of Patients
With Acute Coronary Syndromes: @CircAHA @JACCJournals

🥸Here are class 1 recommendations from the document; Massive effort - congratulations to the authors: @SVRaoMD

😱 Below

👇👇👇 Image
🥸1️⃣ In patients with suspected ACS, a 12-lead ECG should be acquired and interpreted within 10 minutes of first medical contact to identify patients with STEMI.
🥸2️⃣ In patients with suspected ACS in which the initial ECG is nondiagnostic of STEMI, serial ECGs to detect potential ischemic changes should be performed, especially when clinical suspicion of ACS is high, symptoms are persistent, or the clinical condition deteriorates.
Read 37 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Feb 3
The Physiology of Hunger: @NEJM

🥸 So this is not in CV medicine, but:
(1) it is interesting and (2) it has implications for CV

😱 Good job @NEJM - Summary

👇👇👇 Image
🥸 1️⃣ Hunger is an ancient survival mechanism that evolved to keep humans alive in times of food scarcity.
🥸 2️⃣ Early humans were hunter-gatherers, who faced unpredictable food supplies. Their bodies adapted to store energy efficiently, to help with survival during famine.
Read 21 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Jan 28
Abelacimab versus Rivaroxaban in Patients with Atrial Fibrillation: @NEJM

🥸Summary

👇👇👇 Image
🥸 1️⃣ Abelacimab significantly reduced bleeding in atrial fibrillation patients compared to rivaroxaban, as reported in the AZALEA–TIMI 71 trial.
🥸 2️⃣ Monthly subcutaneous abelacimab achieved a 99% reduction in free factor XI levels at 150 mg and 97% at 90 mg.
Read 21 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Jan 7
Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy: @NEJM

🥸 Vutrisiran is promising: congratulations to authors!

👇👇👇 Image
🥸 1/ ATTR-CM is a progressive, fatal disease. It occurs due to misfolded transthyretin proteins depositing in the heart muscle, causing infiltrative cardiomyopathy. Vutrisiran, an RNA interference agent, offers new therapy by targeting the production of hepatic transthyretin.
🥸 2/ The HELIOS-B trial evaluated vutrisiran in 655 patients with ATTR-CM. Patients were randomized 1:1 to receive vutrisiran (25 mg subcutaneously every 12 weeks) or placebo for up to 36 months.
Read 21 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Dec 21, 2024
Atrial Fibrillation: @JAMA_current

🥸 Nice review in JAMA on AF by @darae_ko and team; congratulations.

😱 20-points here

👇👇👇 Image
🥸 1️⃣ Atrial fibrillation (AF) affects ~10.55 million US adults. It increases the risk of stroke, heart failure (HF), myocardial infarction, chronic kidney disease, dementia, and death.

😱Managing AF effectively is critical to improving CV outcomes.
🥸 2️⃣ AF symptoms range from palpitations, shortness of breath, chest pain, presyncope, and fatigue to being completely asymptomatic.

😱About 10-40% of people with AF don’t notice symptoms, which makes screening and incidental detection critical.
Read 23 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Nov 17, 2024
Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity: @NEJM

🥸The SUMMIT trial - @AHAScience

😱 Summary

👇👇👇 Image
🥸 1️⃣ Obesity drives heart failure with preserved ejection fraction (HFpEF) through systemic inflammation and visceral adiposity. Tirzepatide, a dual GIP and GLP-1 receptor agonist, offers weight loss and potential cardiovascular benefits.
🥸 2️⃣ The SUMMIT trial evaluated 731 HFpEF patients with obesity (BMI ≥30), randomized to tirzepatide or placebo for 52 weeks. Primary outcomes were a composite of cardiovascular death or worsening HF events and improvement in health status (KCCQ-CSS).
Read 21 tweets

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