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Abdulla A. Damluji, MD, PhD Profile picture
@DrDamluji
Nov 4, 2021 • 5 tweets • 4 min read • Read on X
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SUGAR trial @TCTMD

Cre8 EVO stent (70-80 microm) vs Zotarolimus DES stent

Study population: Patients with diabetics

Outcome target lesion failure (TLF) at 1 year

Design - non-inferiority trial
Procedural characteristics

between Cre8 EVO vs Resolute
anti platelets
Ok lets not get this wrong

This one met non-inferiority criteria for risk of TLF at one year

Is this correct? @SVRaoMD 😁
This may be helpful recap

Re: where the confidence interval is in relation to the null (1) and non-inferiority margin

In Sugar trial, they actually established superiority of Ceo8 EVO stent over Resolute

Which is basically choice A below

Correct me if I am wrong, @SVRaoMD

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More from @DrDamluji

Abdulla A. Damluji, MD, PhD Profile picture
Jul 21
Tenecteplase for Ischemic Stroke at 4.5 to 24 Hours without Thrombectomy: @NEJM

🥸 There are many parallels between ischemic strokes and ACS Mx

😱Summary and have a nice Sunday

👇👇👇 Image
🥸 1️⃣ Intravenous thrombolytic agents, such as alteplase, are recommended for eligible patients to be administered within 4.5 hours after the onset of an acute ischemic stroke to maximize the chances of recovery.
🥸 2️⃣ Tenecteplase, a genetically modified form of human tissue plasminogen activator, has been shown to be noninferior to alteplase for the treatment of ischemic stroke.
Read 22 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Mar 23
Ticagrelor or Clopidogrel Monotherapy vs Dual Antiplatelet Therapy After Percutaneous Coronary InterventionA Systematic Review and Patient-Level Meta-Analysis: @JAMACardio

🥸 Good morning: more on SAPT monotherapy vs DAPT

😱Summary

👇👇👇 Image
1.🥸 Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is standard post-PCI to minimize ischemic events, but it increases bleeding risk. Emerging studies prompt a reassessment.

😱 Mainly, in high risk groups: older adults.
2. 🥸 Short DAPT durations followed by P2Y12 inhibitor monotherapy have shown promising reductions in bleeding but raised concerns re ischemic risks in high-risk patients.
Read 13 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Mar 14
Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With Left Main Disease With or Without Diabetes: Findings From a Pooled Analysis of 4 Randomized Clinical Trials: @CircAHA

🥸wow: more on left main+diabetes: PCI vs CABG!

😱 Summary

👇👇👇 Image
1/ 🥸 Left main coronary artery disease and diabetes are associated with substantial cardiovascular morbidity and mortality.
2/ 🥸 Yet, long-term outcomes for patients with left main disease and diabetes undergoing PCI compared with CABG remain unclear.
Read 22 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Dec 3, 2023
Critical Care Management of Patients After Cardiac Arrest: A Scientific Statement From the American Heart Association and Neurocritical Care Society: @CircAHA

🥸Great work: @AHA_Research @AHA_AcuteCVCare

😱Let's summarize: Happy Sunday :)

👇👇👇 Image
1/🥸 Cardiac Arrest Prevalence: Over 600,000 individuals in the US experience cardiac arrest annually.

😱This is a significant public health problem.
2/ 🥸 Worldwide Incidence: Globally, cardiac arrest occurs in 30 to 97 individuals per 100,000 population.
Read 21 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Nov 12, 2023
Great #AHA23 so far: @AHA_Research

🥸8 Trials: 8 take aways below

Read the read👇👇

1/ATRESIA:

Patients with subclinical atrial fibrillation can benefit from apixaban to reduce the risk of stroke and systemic thromboembolism. Image
2/CARDIA-SSBP:

🥸The decline in SBP with a low-sodium diet was independent of hypertension status and anti-hypertensive medication use, consistent across subgroups, and did not result in excess adverse Image
3/ CRHCP:

🥸Intensive BP lowering (target BP < 130/80 mm Hg) significantly reduced risk of all-cause dementia among patients with hypertension, supporting the use of intensive hypertension treatment to reduce the burden of dementia.

😱 @cardskrish Image
Read 11 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Nov 11, 2023
Semaglutide and Cardiovascular Outcomes
in Obesity without Diabetes: @NEJM

The select trial: #AHA23

🥸Wow! @AHA_Research

😱Now on the stage in main event

😱Let's get the highlights

👇👇👇 Image
1.🥸 GLP-1 receptor agonists are known for cardiovascular benefits in type 2 diabetes.
2.🥸 The SELECT trial tested semaglutide, a potent member of GLP-1 class of drugs, for cardiovascular risk in overweight individuals without diabetes history.
Read 19 tweets

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